These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

245 related items for PubMed ID: 12819349

  • 21. Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site.
    Jackman JE, Raetz CR, Fierke CA.
    Biochemistry; 2001 Jan 16; 40(2):514-23. PubMed ID: 11148046
    [Abstract] [Full Text] [Related]

  • 22. Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase.
    Gennadios HA, Whittington DA, Li X, Fierke CA, Christianson DW.
    Biochemistry; 2006 Jul 04; 45(26):7940-8. PubMed ID: 16800620
    [Abstract] [Full Text] [Related]

  • 23. Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor.
    Mochalkin I, Knafels JD, Lightle S.
    Protein Sci; 2008 Mar 04; 17(3):450-7. PubMed ID: 18287278
    [Abstract] [Full Text] [Related]

  • 24. Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli.
    Barb AW, McClerren AL, Snehelatha K, Reynolds CM, Zhou P, Raetz CR.
    Biochemistry; 2007 Mar 27; 46(12):3793-802. PubMed ID: 17335290
    [Abstract] [Full Text] [Related]

  • 25. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) inhibitors: a new class of antibacterial agents.
    Zhang J, Zhang L, Li X, Xu W.
    Curr Med Chem; 2012 Mar 27; 19(13):2038-50. PubMed ID: 22414079
    [Abstract] [Full Text] [Related]

  • 26. Zinc hydrolases: the mechanisms of zinc-dependent deacetylases.
    Hernick M, Fierke CA.
    Arch Biochem Biophys; 2005 Jan 01; 433(1):71-84. PubMed ID: 15581567
    [Abstract] [Full Text] [Related]

  • 27. Recent Process in the Inhibitors of UDP-3-O-(R-3-hydroxyacyl)-Nacetylglucosamine Deacetylase (LpxC) Against Gram-Negative Bacteria.
    Liu F, Ma S.
    Mini Rev Med Chem; 2018 Jan 01; 18(4):310-323. PubMed ID: 27739357
    [Abstract] [Full Text] [Related]

  • 28. UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism.
    Hernick M, Gennadios HA, Whittington DA, Rusche KM, Christianson DW, Fierke CA.
    J Biol Chem; 2005 Apr 29; 280(17):16969-78. PubMed ID: 15705580
    [Abstract] [Full Text] [Related]

  • 29. Synthesis of a carbohydrate-derived hydroxamic acid inhibitor of the bacterial enzyme (LpxC) involved in lipid A biosynthesis.
    Li X, Uchiyama T, Raetz CR, Hindsgaul O.
    Org Lett; 2003 Feb 20; 5(4):539-41. PubMed ID: 12583763
    [Abstract] [Full Text] [Related]

  • 30. Insights into the Zinc-Dependent Deacetylase LpxC: Biochemical Properties and Inhibitor Design.
    Kalinin DV, Holl R.
    Curr Top Med Chem; 2016 Feb 20; 16(21):2379-430. PubMed ID: 27072691
    [Abstract] [Full Text] [Related]

  • 31. A new class of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitors for the treatment of Gram-negative infections: PCT application WO 2008027466.
    Cuny GD.
    Expert Opin Ther Pat; 2009 Jun 20; 19(6):893-9. PubMed ID: 19473108
    [Abstract] [Full Text] [Related]

  • 32. Binding of uridine 5'-diphosphate in the "basic patch" of the zinc deacetylase LpxC and implications for substrate binding.
    Gennadios HA, Christianson DW.
    Biochemistry; 2006 Dec 26; 45(51):15216-23. PubMed ID: 17176043
    [Abstract] [Full Text] [Related]

  • 33. N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay.
    Furuya T, Shapiro AB, Comita-Prevoir J, Kuenstner EJ, Zhang J, Ribe SD, Chen A, Hines D, Moussa SH, Carter NM, Sylvester MA, Romero JAC, Vega CV, Sacco MD, Chen Y, O'Donnell JP, Durand-Reville TF, Miller AA, Tommasi RA.
    Bioorg Med Chem; 2020 Dec 15; 28(24):115826. PubMed ID: 33160146
    [Abstract] [Full Text] [Related]

  • 34. Antibacterial Drug Discovery Targeting the Lipopolysaccharide Biosynthetic Enzyme LpxC.
    Erwin AL.
    Cold Spring Harb Perspect Med; 2016 Jul 01; 6(7):. PubMed ID: 27235477
    [Abstract] [Full Text] [Related]

  • 35. Nucleotide substrate recognition by UDP-N-acetylglucosamine acyltransferase (LpxA) in the first step of lipid A biosynthesis.
    Ulaganathan V, Buetow L, Hunter WN.
    J Mol Biol; 2007 Jun 01; 369(2):305-12. PubMed ID: 17434525
    [Abstract] [Full Text] [Related]

  • 36. Active site metal ion in UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) switches between Fe(II) and Zn(II) depending on cellular conditions.
    Gattis SG, Hernick M, Fierke CA.
    J Biol Chem; 2010 Oct 29; 285(44):33788-96. PubMed ID: 20709752
    [Abstract] [Full Text] [Related]

  • 37. Structure-based discovery of LpxC inhibitors.
    Zhang J, Chan A, Lippa B, Cross JB, Liu C, Yin N, Romero JA, Lawrence J, Heney R, Herradura P, Goss J, Clark C, Abel C, Zhang Y, Poutsiaka KM, Epie F, Conrad M, Mahamoon A, Nguyen K, Chavan A, Clark E, Li TC, Cheng RK, Wood M, Andersen OA, Brooks M, Kwong J, Barker J, Parr IB, Gu Y, Ryan MD, Coleman S, Metcalf CA.
    Bioorg Med Chem Lett; 2017 Apr 15; 27(8):1670-1680. PubMed ID: 28302397
    [Abstract] [Full Text] [Related]

  • 38. Structure of the bacterial deacetylase LpxC bound to the nucleotide reaction product reveals mechanisms of oxyanion stabilization and proton transfer.
    Clayton GM, Klein DJ, Rickert KW, Patel SB, Kornienko M, Zugay-Murphy J, Reid JC, Tummala S, Sharma S, Singh SB, Miesel L, Lumb KJ, Soisson SM.
    J Biol Chem; 2013 Nov 22; 288(47):34073-34080. PubMed ID: 24108127
    [Abstract] [Full Text] [Related]

  • 39. High-throughput catch-and-release synthesis of oxazoline hydroxamates. Structure-activity relationships in novel inhibitors of Escherichia coli LpxC: in vitro enzyme inhibition and antibacterial properties.
    Pirrung MC, Tumey LN, McClerren AL, Raetz CR.
    J Am Chem Soc; 2003 Feb 12; 125(6):1575-86. PubMed ID: 12568618
    [Abstract] [Full Text] [Related]

  • 40. EXAFS studies of the zinc sites of UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC).
    McClure CP, Rusche KM, Peariso K, Jackman JE, Fierke CA, Penner-Hahn JE.
    J Inorg Biochem; 2003 Feb 01; 94(1-2):78-85. PubMed ID: 12620676
    [Abstract] [Full Text] [Related]

    Page: [Previous] [Next] [New Search]
    of 13.