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Journal Abstract Search

144 related items for PubMed ID: 12825948

  • 1. Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids.
    Conti P, De Amici M, Joppolo Di Ventimiglia S, Stensbøl TB, Madsen U, Bräuner-Osborne H, Russo E, De Sarro G, Bruno G, De Micheli C.
    J Med Chem; 2003 Jul 03; 46(14):3102-8. PubMed ID: 12825948
    [Abstract] [Full Text] [Related]

  • 2. 4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues.
    Lolli ML, Giordano C, Pickering DS, Rolando B, Hansen KB, Foti A, Contreras-Sanz A, Amir A, Fruttero R, Gasco A, Nielsen B, Johansen TN.
    J Med Chem; 2010 May 27; 53(10):4110-8. PubMed ID: 20408529
    [Abstract] [Full Text] [Related]

  • 3. Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists.
    Conti P, De Amici M, Grazioso G, Roda G, Barberis Negra FF, Nielsen B, Stensbøl TB, Madsen U, Bräuner-Osborne H, Frydenvang K, De Sarro G, Toma L, De Micheli C.
    J Med Chem; 2004 Dec 30; 47(27):6740-8. PubMed ID: 15615523
    [Abstract] [Full Text] [Related]

  • 4. Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids.
    Conti P, De Amici M, Grazioso G, Roda G, Pinto A, Hansen KB, Nielsen B, Madsen U, Bräuner-Osborne H, Egebjerg J, Vestri V, Pellegrini-Giampietro DE, Sibille P, Acher FC, De Micheli C.
    J Med Chem; 2005 Oct 06; 48(20):6315-25. PubMed ID: 16190758
    [Abstract] [Full Text] [Related]

  • 5. Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists.
    Nakazato A, Kumagai T, Sakagami K, Yoshikawa R, Suzuki Y, Chaki S, Ito H, Taguchi T, Nakanishi S, Okuyama S.
    J Med Chem; 2000 Dec 14; 43(25):4893-909. PubMed ID: 11123999
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors.
    Madsen U, Bräuner-Osborne H, Frydenvang K, Hvene L, Johansen TN, Nielsen B, Sánchez C, Stensbøl TB, Bischoff F, Krogsgaard-Larsen P.
    J Med Chem; 2001 Mar 29; 44(7):1051-9. PubMed ID: 11297452
    [Abstract] [Full Text] [Related]

  • 7. Synthesis of conformationally constrained glutamic acid homologues and investigation of their pharmacological profiles.
    Conti P, Pinto A, Tamborini L, Grazioso G, De Sarro G, Bräuner-Osborne H, Szabo G, Gábor Hársing L, De Micheli C.
    ChemMedChem; 2007 Nov 29; 2(11):1639-47. PubMed ID: 17849399
    [Abstract] [Full Text] [Related]

  • 8. Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid.
    Johansen TN, Ebert B, Bräuner-Osborne H, Didriksen M, Christensen IT, Søby KK, Madsen U, Krogsgaard-Larsen P, Brehm L.
    J Med Chem; 1998 Mar 12; 41(6):930-9. PubMed ID: 9526567
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.
    Kozikowski AP, Steensma D, Araldi GL, Tückmantel W, Wang S, Pshenichkin S, Surina E, Wroblewski JT.
    J Med Chem; 1998 May 07; 41(10):1641-50. PubMed ID: 9572889
    [Abstract] [Full Text] [Related]

  • 10. N-methyl-D-aspartic acid receptor agonists: resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.
    Madsen U, Frydenvang K, Ebert B, Johansen TN, Brehm L, Krogsgaard-Larsen P.
    J Med Chem; 1996 Jan 05; 39(1):183-90. PubMed ID: 8568805
    [Abstract] [Full Text] [Related]

  • 11. 4-substituted-3-phenylquinolin-2(1H)-ones: acidic and nonacidic glycine site N-methyl-D-aspartate antagonists with in vivo activity.
    Carling RW, Leeson PD, Moore KW, Moyes CR, Duncton M, Hudson ML, Baker R, Foster AC, Grimwood S, Kemp JA, Marshall GR, Tricklebank MD, Saywell KL.
    J Med Chem; 1997 Feb 28; 40(5):754-65. PubMed ID: 9057862
    [Abstract] [Full Text] [Related]

  • 12. Synthesis of novel pyrrolo[3,4-d]pyrazole-dicarboxylic acids and evaluation of their interaction with glutamate receptors.
    Conti P, di Ventimiglia SJ, Pinto A, Tamborini L, Menniti FS, Lazzaro JT, De Micheli C.
    Chem Biodivers; 2008 Apr 28; 5(4):657-63. PubMed ID: 18421758
    [Abstract] [Full Text] [Related]

  • 13. Novel 3-carboxy- and 3-phosphonopyrazoline amino acids as potent and selective NMDA receptor antagonists: design, synthesis, and pharmacological characterization.
    Conti P, Pinto A, Tamborini L, Madsen U, Nielsen B, Bräuner-Osborne H, Hansen KB, Landucci E, Pellegrini-Giampietro DE, De Sarro G, Donato Di Paola E, De Micheli C.
    ChemMedChem; 2010 Sep 03; 5(9):1465-75. PubMed ID: 20665761
    [Abstract] [Full Text] [Related]

  • 14. Synthesis and metabotropic glutamate receptor activity of a 2-aminobicyclo[3.2.0]heptane-2,5-dicarboxylic acid, a molecule possessing an extended glutamate conformation.
    Kozikowski AP, Araldi GL, Flippen-Anderson J, George C, Pshenichkin S, Surina E, Wroblewski J.
    Bioorg Med Chem Lett; 1998 Apr 21; 8(8):925-30. PubMed ID: 9871513
    [Abstract] [Full Text] [Related]

  • 15. Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).
    Bjerrum EJ, Kristensen AS, Pickering DS, Greenwood JR, Nielsen B, Liljefors T, Schousboe A, Bräuner-Osborne H, Madsen U.
    J Med Chem; 2003 May 22; 46(11):2246-9. PubMed ID: 12747796
    [Abstract] [Full Text] [Related]

  • 16. Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology.
    Frølund B, Greenwood JR, Holm MM, Egebjerg J, Madsen U, Nielsen B, Bräuner-Osborne H, Stensbøl TB, Krogsgaard-Larsen P.
    Bioorg Med Chem; 2005 Sep 15; 13(18):5391-8. PubMed ID: 16043357
    [Abstract] [Full Text] [Related]

  • 17. Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors.
    Jørgensen CG, Bräuner-Osborne H, Nielsen B, Kehler J, Clausen RP, Krogsgaard-Larsen P, Madsen U.
    Bioorg Med Chem; 2007 May 15; 15(10):3524-38. PubMed ID: 17376693
    [Abstract] [Full Text] [Related]

  • 18. Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA.
    Johansen TN, Stensbøl TB, Nielsen B, Vogensen SB, Frydenvang K, Sløk FA, Bräüner-Osborne H, Madsen U, Krogsgaard-Larsen P.
    Chirality; 2001 May 15; 13(9):523-32. PubMed ID: 11579444
    [Abstract] [Full Text] [Related]

  • 19. Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors.
    Hermit MB, Greenwood JR, Nielsen B, Bunch L, Jørgensen CG, Vestergaard HT, Stensbøl TB, Sanchez C, Krogsgaard-Larsen P, Madsen U, Bräuner-Osborne H.
    Eur J Pharmacol; 2004 Feb 23; 486(3):241-50. PubMed ID: 14985045
    [Abstract] [Full Text] [Related]

  • 20. Synthesis and pharmacological evaluation of novel conformationally constrained homologues of glutamic acid.
    Conti P, Caligiuri A, Pinto A, Roda G, Tamborini L, Nielsen B, Madsen U, Frydenvang K, Colombo A, De Micheli C.
    Eur J Med Chem; 2007 Aug 23; 42(8):1059-68. PubMed ID: 17346858
    [Abstract] [Full Text] [Related]

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