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255 related items for PubMed ID: 12842885

  • 1. Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs.
    Dobrosotskaya IY, Goldstein JL, Brown MS, Rawson RB.
    J Biol Chem; 2003 Sep 12; 278(37):35837-43. PubMed ID: 12842885
    [Abstract] [Full Text] [Related]

  • 2. Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi.
    Nohturfft A, DeBose-Boyd RA, Scheek S, Goldstein JL, Brown MS.
    Proc Natl Acad Sci U S A; 1999 Sep 28; 96(20):11235-40. PubMed ID: 10500160
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  • 3. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.
    Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R, Goldstein JL, Brown MS.
    Cell; 2002 Aug 23; 110(4):489-500. PubMed ID: 12202038
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  • 4. Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum.
    Yang T, Goldstein JL, Brown MS.
    J Biol Chem; 2000 Sep 22; 275(38):29881-6. PubMed ID: 10896675
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  • 5. Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites.
    Su L, Zhou L, Chen FJ, Wang H, Qian H, Sheng Y, Zhu Y, Yu H, Gong X, Cai L, Yang X, Xu L, Zhao TJ, Li JZ, Chen XW, Li P.
    EMBO J; 2019 Apr 15; 38(8):. PubMed ID: 30858281
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  • 10. PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus.
    Xu D, Wang Z, Zhang Y, Jiang W, Pan Y, Song BL, Chen Y.
    Nat Commun; 2015 Aug 27; 6():8100. PubMed ID: 26311497
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  • 15. COPI-mediated retrieval of SCAP is crucial for regulating lipogenesis under basal and sterol-deficient conditions.
    Takashima K, Saitoh A, Funabashi T, Hirose S, Yagi C, Nozaki S, Sato R, Shin HW, Nakayama K.
    J Cell Sci; 2015 Aug 01; 128(15):2805-15. PubMed ID: 26092941
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  • 18. The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage.
    Irisawa M, Inoue J, Ozawa N, Mori K, Sato R.
    J Biol Chem; 2009 Oct 16; 284(42):28995-9004. PubMed ID: 19706601
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  • 19. Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake.
    Gong Y, Lee JN, Lee PC, Goldstein JL, Brown MS, Ye J.
    Cell Metab; 2006 Jan 16; 3(1):15-24. PubMed ID: 16399501
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  • 20. Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies.
    Sakai J, Nohturfft A, Goldstein JL, Brown MS.
    J Biol Chem; 1998 Mar 06; 273(10):5785-93. PubMed ID: 9488713
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