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Journal Abstract Search

208 related items for PubMed ID: 12852749

  • 1. First dual aromatase-steroid sulfatase inhibitors.
    Woo LW, Sutcliffe OB, Bubert C, Grasso A, Chander SK, Purohit A, Reed MJ, Potter BV.
    J Med Chem; 2003 Jul 17; 46(15):3193-6. PubMed ID: 12852749
    [Abstract] [Full Text] [Related]

  • 2. Synthesis and biological activity of the superestrogen (E)-17-oximino-3-O-sulfamoyl-1,3,5(10)-estratriene: x-ray crystal structure of (E)-17-oximino-3-hydroxy-1,3,5(10)-estratriene.
    Hejaz HA, Purohit A, Mahon MF, Reed MJ, Potter BV.
    J Med Chem; 1999 Aug 12; 42(16):3188-92. PubMed ID: 10447965
    [Abstract] [Full Text] [Related]

  • 3. Dual aromatase-steroid sulfatase inhibitors.
    Woo LW, Bubert C, Sutcliffe OB, Smith A, Chander SK, Mahon MF, Purohit A, Reed MJ, Potter BV.
    J Med Chem; 2007 Jul 26; 50(15):3540-60. PubMed ID: 17580845
    [Abstract] [Full Text] [Related]

  • 4. Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template.
    Woo LW, Jackson T, Putey A, Cozier G, Leonard P, Acharya KR, Chander SK, Purohit A, Reed MJ, Potter BV.
    J Med Chem; 2010 Mar 11; 53(5):2155-70. PubMed ID: 20148564
    [Abstract] [Full Text] [Related]

  • 5. Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase.
    Woo LW, Howarth NM, Purohit A, Hejaz HA, Reed MJ, Potter BV.
    J Med Chem; 1998 Mar 26; 41(7):1068-83. PubMed ID: 9544207
    [Abstract] [Full Text] [Related]

  • 6. In vivo activity of 4-methylcoumarin-7-O-sulfamate, a nonsteroidal, nonestrogenic steroid sulfatase inhibitor.
    Purohit A, Woo LW, Singh A, Winterborn CJ, Potter BV, Reed MJ.
    Cancer Res; 1996 Nov 01; 56(21):4950-5. PubMed ID: 8895749
    [Abstract] [Full Text] [Related]

  • 7. Potent inhibition of steroid sulfatase activity by 3-O-sulfamate 17alpha-benzyl(or 4'-tert-butylbenzyl)estra-1,3,5(10)-trienes: combination of two substituents at positions C3 and c17alpha of estradiol.
    Ciobanu LC, Boivin RP, Luu-The V, Labrie F, Poirier D.
    J Med Chem; 1999 Jun 17; 42(12):2280-6. PubMed ID: 10377235
    [Abstract] [Full Text] [Related]

  • 8. Bicyclic derivatives of the potent dual aromatase-steroid sulfatase inhibitor 2-bromo-4-{[(4-cyanophenyl)(4h-1,2,4-triazol-4-yl)amino]methyl}phenylsulfamate: synthesis, SAR, crystal structure, and in vitro and in vivo activities.
    Wood PM, Woo LW, Labrosse JR, Thomas MP, Mahon MF, Chander SK, Purohit A, Reed MJ, Potter BV.
    ChemMedChem; 2010 Sep 03; 5(9):1577-93. PubMed ID: 20632362
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of estrone sulfate-induced uterine growth by potent nonestrogenic steroidal inhibitors of steroid sulfatase.
    Ciobanu LC, Luu-The V, Martel C, Labrie F, Poirier D.
    Cancer Res; 2003 Oct 01; 63(19):6442-6. PubMed ID: 14559834
    [Abstract] [Full Text] [Related]

  • 10. Synthesis of aromatase inhibitors and dual aromatase steroid sulfatase inhibitors by linking an arylsulfamate motif to 4-(4H-1,2,4-triazol-4-ylamino)benzonitrile: SAR, crystal structures, in vitro and in vivo activities.
    Bubert C, Woo LW, Sutcliffe OB, Mahon MF, Chander SK, Purohit A, Reed MJ, Potter BV.
    ChemMedChem; 2008 Nov 01; 3(11):1708-30. PubMed ID: 18816537
    [Abstract] [Full Text] [Related]

  • 11. 2-phenylindole sulfamates: inhibitors of steroid sulfatase with antiproliferative activity in MCF-7 breast cancer cells.
    Walter G, Liebl R, von Angerer E.
    J Steroid Biochem Mol Biol; 2004 Apr 01; 88(4-5):409-20. PubMed ID: 15145451
    [Abstract] [Full Text] [Related]

  • 12. Structure-activity relationships of 17alpha-derivatives of estradiol as inhibitors of steroid sulfatase.
    Boivin RP, Luu-The V, Lachance R, Labrie F, Poirier D.
    J Med Chem; 2000 Nov 16; 43(23):4465-78. PubMed ID: 11087571
    [Abstract] [Full Text] [Related]

  • 13. In vitro and in vivo models for the evaluation of new inhibitors of human steroid sulfatase, devoid of residual estrogenic activity.
    Shields-Botella J, Bonnet P, Duc I, Duranti E, Meschi S, Cardinali S, Prouheze P, Chaigneau AM, Duranti V, Gribaudo S, Rivière A, Mengual L, Carniato D, Cecchet L, Lafay J, Rondot B, Sandri J, Pascal JC, Delansorne R.
    J Steroid Biochem Mol Biol; 2003 Feb 16; 84(2-3):327-35. PubMed ID: 12711019
    [Abstract] [Full Text] [Related]

  • 14. Dual aromatase-sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activity.
    Jackson T, Woo LW, Trusselle MN, Chander SK, Purohit A, Reed MJ, Potter BV.
    Org Biomol Chem; 2007 Sep 21; 5(18):2940-52. PubMed ID: 17728860
    [Abstract] [Full Text] [Related]

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  • 16. Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity.
    Wood PM, Woo LW, Labrosse JR, Trusselle MN, Abbate S, Longhi G, Castiglioni E, Lebon F, Purohit A, Reed MJ, Potter BV.
    J Med Chem; 2008 Jul 24; 51(14):4226-38. PubMed ID: 18590272
    [Abstract] [Full Text] [Related]

  • 17. Development of novel steroid sulfatase inhibitors; II. TZS-8478 potently inhibits the growth of breast tumors in postmenopausal breast cancer model rats.
    Saito T, Kinoshita S, Fujii T, Bandoh K, Fuse S, Yamauchi Y, Koizumi N, Horiuchi T.
    J Steroid Biochem Mol Biol; 2004 Feb 24; 88(2):167-73. PubMed ID: 15084348
    [Abstract] [Full Text] [Related]

  • 18. A new therapeutic strategy against hormone-dependent breast cancer: the preclinical development of a dual aromatase and sulfatase inhibitor.
    Foster PA, Chander SK, Newman SP, Woo LW, Sutcliffe OB, Bubert C, Zhou D, Chen S, Potter BV, Reed MJ, Purohit A.
    Clin Cancer Res; 2008 Oct 15; 14(20):6469-77. PubMed ID: 18927286
    [Abstract] [Full Text] [Related]

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  • 20. Solid-phase parallel synthesis of 17alpha-substituted estradiol sulfamate and phenol libraries using the multidetachable sulfamate linker.
    Ciobanu LC, Poirier D.
    J Comb Chem; 2003 Oct 15; 5(4):429-40. PubMed ID: 12857111
    [Abstract] [Full Text] [Related]

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