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189 related items for PubMed ID: 12853454

  • 1. Signaling mechanisms leading to the regulation of differentiation and apoptosis of articular chondrocytes by insulin-like growth factor-1.
    Oh CD, Chun JS.
    J Biol Chem; 2003 Sep 19; 278(38):36563-71. PubMed ID: 12853454
    [Abstract] [Full Text] [Related]

  • 2. ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status.
    Kim SJ, Ju JW, Oh CD, Yoon YM, Song WK, Kim JH, Yoo YJ, Bang OS, Kang SS, Chun JS.
    J Biol Chem; 2002 Jan 11; 277(2):1332-9. PubMed ID: 11689560
    [Abstract] [Full Text] [Related]

  • 3. p38 kinase-dependent and -independent Inhibition of protein kinase C zeta and -alpha regulates nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes.
    Kim SJ, Kim HG, Oh CD, Hwang SG, Song WK, Yoo YJ, Kang SS, Chun JS.
    J Biol Chem; 2002 Aug 16; 277(33):30375-81. PubMed ID: 12048219
    [Abstract] [Full Text] [Related]

  • 4. Protein kinase C alpha and zeta regulate nitric oxide-induced NF-kappa B activation that mediates cyclooxygenase-2 expression and apoptosis but not dedifferentiation in articular chondrocytes.
    Kim SJ, Chun JS.
    Biochem Biophys Res Commun; 2003 Mar 28; 303(1):206-11. PubMed ID: 12646188
    [Abstract] [Full Text] [Related]

  • 5. Actin cytoskeletal architecture regulates nitric oxide-induced apoptosis, dedifferentiation, and cyclooxygenase-2 expression in articular chondrocytes via mitogen-activated protein kinase and protein kinase C pathways.
    Kim SJ, Hwang SG, Kim IC, Chun JS.
    J Biol Chem; 2003 Oct 24; 278(43):42448-56. PubMed ID: 12907684
    [Abstract] [Full Text] [Related]

  • 6. Maintenance of differentiated phenotype of articular chondrocytes by protein kinase C and extracellular signal-regulated protein kinase.
    Yoon YM, Kim SJ, Oh CD, Ju JW, Song WK, Yoo YJ, Huh TL, Chun JS.
    J Biol Chem; 2002 Mar 08; 277(10):8412-20. PubMed ID: 11744731
    [Abstract] [Full Text] [Related]

  • 7. Non-steroidal anti-inflammatory drugs inhibit nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes independent of cyclooxygenase activity.
    Yoon JB, Kim SJ, Hwang SG, Chang S, Kang SS, Chun JS.
    J Biol Chem; 2003 Apr 25; 278(17):15319-25. PubMed ID: 12588866
    [Abstract] [Full Text] [Related]

  • 8. Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms.
    Hwang SG, Ryu JH, Kim IC, Jho EH, Jung HC, Kim K, Kim SJ, Chun JS.
    J Biol Chem; 2004 Jun 18; 279(25):26597-604. PubMed ID: 15082716
    [Abstract] [Full Text] [Related]

  • 9. Differentiation status-dependent regulation of cyclooxygenase-2 expression and prostaglandin E2 production by epidermal growth factor via mitogen-activated protein kinase in articular chondrocytes.
    Huh YH, Kim SH, Kim SJ, Chun JS.
    J Biol Chem; 2003 Mar 14; 278(11):9691-7. PubMed ID: 12493746
    [Abstract] [Full Text] [Related]

  • 10. p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent transcription and stabilization by serine 15 phosphorylation.
    Kim SJ, Hwang SG, Shin DY, Kang SS, Chun JS.
    J Biol Chem; 2002 Sep 06; 277(36):33501-8. PubMed ID: 12091386
    [Abstract] [Full Text] [Related]

  • 11. IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway.
    Montaseri A, Busch F, Mobasheri A, Buhrmann C, Aldinger C, Rad JS, Shakibaei M.
    PLoS One; 2011 Sep 06; 6(12):e28663. PubMed ID: 22194879
    [Abstract] [Full Text] [Related]

  • 12. Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathway.
    Qiao M, Shapiro P, Kumar R, Passaniti A.
    J Biol Chem; 2004 Oct 08; 279(41):42709-18. PubMed ID: 15304489
    [Abstract] [Full Text] [Related]

  • 13. Epidermal growth factor negatively regulates chondrogenesis of mesenchymal cells by modulating the protein kinase C-alpha, Erk-1, and p38 MAPK signaling pathways.
    Yoon YM, Oh CD, Kim DY, Lee YS, Park JW, Huh TL, Kang SS, Chun JS.
    J Biol Chem; 2000 Apr 21; 275(16):12353-9. PubMed ID: 10766877
    [Abstract] [Full Text] [Related]

  • 14. Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway.
    Tanaka Y, Gavrielides MV, Mitsuuchi Y, Fujii T, Kazanietz MG.
    J Biol Chem; 2003 Sep 05; 278(36):33753-62. PubMed ID: 12824193
    [Abstract] [Full Text] [Related]

  • 15. Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB.
    Shalom-Barak T, Quach J, Lotz M.
    J Biol Chem; 1998 Oct 16; 273(42):27467-73. PubMed ID: 9765276
    [Abstract] [Full Text] [Related]

  • 16. The thymoquinone-induced production of reactive oxygen species promotes dedifferentiation through the ERK pathway and inflammation through the p38 and PI3K pathways in rabbit articular chondrocytes.
    Yu SM, Kim SJ.
    Int J Mol Med; 2015 Feb 16; 35(2):325-32. PubMed ID: 25435376
    [Abstract] [Full Text] [Related]

  • 17. Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways.
    Yin W, Park JI, Loeser RF.
    J Biol Chem; 2009 Nov 13; 284(46):31972-81. PubMed ID: 19762915
    [Abstract] [Full Text] [Related]

  • 18. microRNA-206 is required for osteoarthritis development through its effect on apoptosis and autophagy of articular chondrocytes via modulating the phosphoinositide 3-kinase/protein kinase B-mTOR pathway by targeting insulin-like growth factor-1.
    Yu Q, Zhao B, He Q, Zhang Y, Peng XB.
    J Cell Biochem; 2019 Apr 13; 120(4):5287-5303. PubMed ID: 30335903
    [Abstract] [Full Text] [Related]

  • 19. Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3'-kinase signaling pathway.
    Chrysis D, Zaman F, Chagin AS, Takigawa M, Sävendahl L.
    Endocrinology; 2005 Mar 13; 146(3):1391-7. PubMed ID: 15576458
    [Abstract] [Full Text] [Related]

  • 20. In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein.
    Mehrhof FB, Müller FU, Bergmann MW, Li P, Wang Y, Schmitz W, Dietz R, von Harsdorf R.
    Circulation; 2001 Oct 23; 104(17):2088-94. PubMed ID: 11673351
    [Abstract] [Full Text] [Related]


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