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182 related items for PubMed ID: 12860205

  • 1. Inverse agonist activity of agouti and agouti-related protein.
    Chai BX, Neubig RR, Millhauser GL, Thompson DA, Jackson PJ, Barsh GS, Dickinson CJ, Li JY, Lai YM, Gantz I.
    Peptides; 2003 Apr; 24(4):603-9. PubMed ID: 12860205
    [Abstract] [Full Text] [Related]

  • 2. Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinants.
    Haskell-Luevano C, Cone RD, Monck EK, Wan YP.
    Biochemistry; 2001 May 22; 40(20):6164-79. PubMed ID: 11352754
    [Abstract] [Full Text] [Related]

  • 3. Molecular basis of melanocortin-4 receptor for AGRP inverse agonism.
    Chen M, Celik A, Georgeson KE, Harmon CM, Yang Y.
    Regul Pept; 2006 Sep 11; 136(1-3):40-9. PubMed ID: 16820227
    [Abstract] [Full Text] [Related]

  • 4. Chimeric NDP-MSH and MTII melanocortin peptides with agouti-related protein (AGRP) Arg-Phe-Phe amino acids possess agonist melanocortin receptor activity.
    Joseph CG, Wilczynski A, Holder JR, Xiang Z, Bauzo RM, Scott JW, Haskell-Luevano C.
    Peptides; 2003 Dec 11; 24(12):1899-908. PubMed ID: 15127941
    [Abstract] [Full Text] [Related]

  • 5. Common requirements for melanocortin-4 receptor selectivity of structurally unrelated melanocortin agonist and endogenous antagonist, Agouti protein.
    Oosterom J, Garner KM, den Dekker WK, Nijenhuis WA, Gispen WH, Burbach JP, Barsh GS, Adan RA.
    J Biol Chem; 2001 Jan 12; 276(2):931-6. PubMed ID: 11024027
    [Abstract] [Full Text] [Related]

  • 6. Elongation studies of the human agouti-related protein (AGRP) core decapeptide (Yc[CRFFNAFC]Y) results in antagonism at the mouse melanocortin-3 receptor.
    Joseph CG, Bauzo RM, Xiang Z, Shaw AM, Millard WJ, Haskell-Luevano C.
    Peptides; 2003 Feb 12; 24(2):263-70. PubMed ID: 12668211
    [Abstract] [Full Text] [Related]

  • 7. Molecular determination of agouti-related protein binding to human melanocortin-4 receptor.
    Yang Y, Chen M, Lai Y, Gantz I, Yagmurlu A, Georgeson KE, Harmon CM.
    Mol Pharmacol; 2003 Jul 12; 64(1):94-103. PubMed ID: 12815165
    [Abstract] [Full Text] [Related]

  • 8. Characterization of Agouti-related protein binding to melanocortin receptors.
    Yang YK, Thompson DA, Dickinson CJ, Wilken J, Barsh GS, Kent SB, Gantz I.
    Mol Endocrinol; 1999 Jan 12; 13(1):148-55. PubMed ID: 9892020
    [Abstract] [Full Text] [Related]

  • 9. Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands.
    Wilczynski A, Wang XS, Joseph CG, Xiang Z, Bauzo RM, Scott JW, Sorensen NB, Shaw AM, Millard WJ, Richards NG, Haskell-Luevano C.
    J Med Chem; 2004 Apr 22; 47(9):2194-207. PubMed ID: 15084118
    [Abstract] [Full Text] [Related]

  • 10. Functional properties of an agouti signaling protein variant and characteristics of its cognate radioligand.
    Yang YK, Dickinson C, Lai YM, Li JY, Gantz I.
    Am J Physiol Regul Integr Comp Physiol; 2001 Dec 22; 281(6):R1877-86. PubMed ID: 11705773
    [Abstract] [Full Text] [Related]

  • 11. Pharmacological characterization of 30 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists, synthetic agonists, and the endogenous agouti-related protein antagonist.
    Xiang Z, Proneth B, Dirain ML, Litherland SA, Haskell-Luevano C.
    Biochemistry; 2010 Jun 08; 49(22):4583-600. PubMed ID: 20462274
    [Abstract] [Full Text] [Related]

  • 12. Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist.
    Xiang Z, Litherland SA, Sorensen NB, Proneth B, Wood MS, Shaw AM, Millard WJ, Haskell-Luevano C.
    Biochemistry; 2006 Jun 13; 45(23):7277-88. PubMed ID: 16752916
    [Abstract] [Full Text] [Related]

  • 13. Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo.
    Ollmann MM, Lamoreux ML, Wilson BD, Barsh GS.
    Genes Dev; 1998 Feb 01; 12(3):316-30. PubMed ID: 9450927
    [Abstract] [Full Text] [Related]

  • 14. Chimeras of the agouti-related protein: insights into agonist and antagonist selectivity of melanocortin receptors.
    Jackson PJ, Yu B, Hunrichs B, Thompson DA, Chai B, Gantz I, Millhauser GL.
    Peptides; 2005 Oct 01; 26(10):1978-87. PubMed ID: 16009463
    [Abstract] [Full Text] [Related]

  • 15. Molecular interaction of Agouti protein and Agouti-related protein with human melanocortin receptors.
    Tota MR, Smith TS, Mao C, MacNeil T, Mosley RT, Van der Ploeg LH, Fong TM.
    Biochemistry; 1999 Jan 19; 38(3):897-904. PubMed ID: 9893984
    [Abstract] [Full Text] [Related]

  • 16. Overview of endogenous and synthetic melanocortin peptides.
    Wilson KR, Todorovic A, Proneth B, Haskell-Luevano C.
    Cell Mol Biol (Noisy-le-grand); 2006 May 30; 52(2):3-20. PubMed ID: 16914082
    [Abstract] [Full Text] [Related]

  • 17. Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor.
    Ericson MD, Freeman KT, Schnell SM, Fleming KA, Haskell-Luevano C.
    J Med Chem; 2017 Oct 12; 60(19):8103-8114. PubMed ID: 28813605
    [Abstract] [Full Text] [Related]

  • 18. Biased signaling initiated by agouti-related peptide through human melanocortin-3 and -4 receptors.
    Yang Z, Tao YX.
    Biochim Biophys Acta; 2016 Sep 12; 1862(9):1485-94. PubMed ID: 27208795
    [Abstract] [Full Text] [Related]

  • 19. Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone.
    Kim MS, Rossi M, Abusnana S, Sunter D, Morgan DG, Small CJ, Edwards CM, Heath MM, Stanley SA, Seal LJ, Bhatti JR, Smith DM, Ghatei MA, Bloom SR.
    Diabetes; 2000 Feb 12; 49(2):177-82. PubMed ID: 10868932
    [Abstract] [Full Text] [Related]

  • 20. Structural characterization and pharmacology of a potent (Cys101-Cys119, Cys110-Cys117) bicyclic agouti-related protein (AGRP) melanocortin receptor antagonist.
    Wilczynski A, Wang XS, Bauzo RM, Xiang Z, Shaw AM, Millard WJ, Richards NG, Edison AS, Haskell-Luevano C.
    J Med Chem; 2004 Nov 04; 47(23):5662-73. PubMed ID: 15509165
    [Abstract] [Full Text] [Related]

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