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177 related items for PubMed ID: 12872145

  • 1. Increased resistance to nitrogen mustards and antifolates following in vitro selection of murine fibroblasts and primary hematopoietic cells transduced with a bicistronic retroviral vector expressing the rat glutathione S-transferase A3 and a mutant dihydrofolate reductase.
    Belzile JP, Karatzas A, Shiu HY, Létourneau S, Palerme JS, Cournoyer D.
    Cancer Gene Ther; 2003 Aug; 10(8):637-46. PubMed ID: 12872145
    [Abstract] [Full Text] [Related]

  • 2. Coexpression of rat glutathione S-transferase A3 and human cytidine deaminase by a bicistronic retroviral vector confers in vitro resistance to nitrogen mustards and cytosine arabinoside in murine fibroblasts.
    Létourneau S, Palerme JS, Delisle JS, Beauséjour CM, Momparler RL, Cournoyer D.
    Cancer Gene Ther; 2000 May; 7(5):757-65. PubMed ID: 10830723
    [Abstract] [Full Text] [Related]

  • 3. Retroviral vectors containing a variant dihydrofolate reductase gene for drug protection and in vivo selection of hematopoietic cells.
    Allay JA, Galipeau J, Blakley RL, Sorrentino BP.
    Stem Cells; 1998 May; 16 Suppl 1():223-33. PubMed ID: 11012166
    [Abstract] [Full Text] [Related]

  • 4. Retrovirus-mediated gene transfer of rat glutathione S-transferase Yc confers alkylating drug resistance in NIH 3T3 mouse fibroblasts.
    Greenbaum M, Létourneau S, Assar H, Schecter RL, Batist G, Cournoyer D.
    Cancer Res; 1994 Aug 15; 54(16):4442-7. PubMed ID: 8044793
    [Abstract] [Full Text] [Related]

  • 5. Retroviral coexpression of thymidylate synthase and dihydrofolate reductase confers fluoropyrimidine and antifolate resistance.
    Fantz CR, Shaw D, Moore JG, Spencer HT.
    Biochem Biophys Res Commun; 1998 Feb 04; 243(1):6-12. PubMed ID: 9473470
    [Abstract] [Full Text] [Related]

  • 6. Protection of CCRF-CEM human lymphoid cells from antifolates by retroviral gene transfer of variants of murine dihydrofolate reductase.
    Mareya SM, Sorrentino BP, Blakley RL.
    Cancer Gene Ther; 1998 Feb 04; 5(4):225-35. PubMed ID: 9694074
    [Abstract] [Full Text] [Related]

  • 7. Retrovirus-mediated gene transfer of rat glutathione S-transferase Yc confers in vitro resistance to alkylating agents in human leukemia cells and in clonogenic mouse hematopoietic progenitor cells.
    Letourneau S, Greenbaum M, Cournoyer D.
    Hum Gene Ther; 1996 May 01; 7(7):831-40. PubMed ID: 8860835
    [Abstract] [Full Text] [Related]

  • 8. Protection of hematopoietic stem cells from pemetrexed toxicity by retroviral gene transfer with a mutant dihydrofolate reductase-mutant thymidylate synthase fusion gene.
    Capiaux GM, Budak-Alpdogan T, Alpdogan O, Bornmann W, Takebe N, Banerjee D, Maley F, Bertino JR.
    Cancer Gene Ther; 2004 Dec 01; 11(12):767-73. PubMed ID: 15359285
    [Abstract] [Full Text] [Related]

  • 9. Generation of dual resistance to 4-hydroperoxycyclophosphamide and methotrexate by retroviral transfer of the human aldehyde dehydrogenase class 1 gene and a mutated dihydrofolate reductase gene.
    Takebe N, Zhao SC, Adhikari D, Mineishi S, Sadelain M, Hilton J, Colvin M, Banerjee D, Bertino JR.
    Mol Ther; 2001 Jan 01; 3(1):88-96. PubMed ID: 11162315
    [Abstract] [Full Text] [Related]

  • 10. A gene transfer strategy for making bone marrow cells resistant to trimetrexate.
    Spencer HT, Sleep SE, Rehg JE, Blakley RL, Sorrentino BP.
    Blood; 1996 Mar 15; 87(6):2579-87. PubMed ID: 8630426
    [Abstract] [Full Text] [Related]

  • 11. Transduction of NIH 3T3 cells with a retrovirus carrying both human MDR1 and glutathione S-transferase pi produces broad-range multidrug resistance.
    Doroshow JH, Metz MZ, Matsumoto L, Winters KA, Sakai M, Muramatsu M, Kane SE.
    Cancer Res; 1995 Sep 15; 55(18):4073-8. PubMed ID: 7664283
    [Abstract] [Full Text] [Related]

  • 12. In vivo selection of retrovirally transduced hematopoietic stem cells.
    Allay JA, Persons DA, Galipeau J, Riberdy JM, Ashmun RA, Blakley RL, Sorrentino BP.
    Nat Med; 1998 Oct 15; 4(10):1136-43. PubMed ID: 9771746
    [Abstract] [Full Text] [Related]

  • 13. A bicistronic retroviral vector for protecting hematopoietic cells against antifolates and P-glycoprotein effluxed drugs.
    Galipeau J, Benaim E, Spencer HT, Blakley RL, Sorrentino BP.
    Hum Gene Ther; 1997 Oct 10; 8(15):1773-83. PubMed ID: 9358027
    [Abstract] [Full Text] [Related]

  • 14. In vivo methotrexate selection of murine hemopoietic cells transduced with a retroviral vector for Gaucher disease.
    Havenga M, Valerio D, Hoogerbrugge P, Es H.
    Gene Ther; 1999 Oct 10; 6(10):1661-9. PubMed ID: 10516714
    [Abstract] [Full Text] [Related]

  • 15. Methotrexate selection of long-term culture initiating cells following transduction of CD34(+) cells with a retrovirus containing a mutated human dihydrofolate reductase gene.
    Takebe N, Xu LC, MacKenzie KL, Bertino JR, Moore MA.
    Cancer Gene Ther; 2002 Mar 10; 9(3):308-20. PubMed ID: 11896448
    [Abstract] [Full Text] [Related]

  • 16. Selective expression of methotrexate-resistant dihydrofolate reductase (DHFR) activity in mice transduced with DHFR retrovirus and administered methotrexate.
    Vinh DB, McIvor RS.
    J Pharmacol Exp Ther; 1993 Nov 10; 267(2):989-96. PubMed ID: 8246174
    [Abstract] [Full Text] [Related]

  • 17. Comparison of methotrexate resistance conferred by a mutated dihydrofolate reductase (DHFR) cDNA in two different retroviral vectors.
    Takebe N, Nakahara S, Zhao SC, Adhikari D, Ural AU, Iwamoto M, Banerjee D, Bertino JR.
    Cancer Gene Ther; 2000 Jun 10; 7(6):910-9. PubMed ID: 10880023
    [Abstract] [Full Text] [Related]

  • 18. Retrovirus-mediated expression of the base excision repair proteins, formamidopyrimidine DNA glycosylase or human oxoguanine DNA glycosylase, protects hematopoietic cells from N,N',N"-triethylenethiophosphoramide (thioTEPA)-induced toxicity in vitro and in vivo.
    Kobune M, Xu Y, Baum C, Kelley MR, Williams DA.
    Cancer Res; 2001 Jul 01; 61(13):5116-25. PubMed ID: 11431349
    [Abstract] [Full Text] [Related]

  • 19. Coexpression of cytidine deaminase and mutant dihydrofolate reductase by a bicistronic retroviral vector confers resistance to cytosine arabinoside and methotrexate.
    Beauséjour CM, Le NL, Létourneau S, Cournoyer D, Momparler RL.
    Hum Gene Ther; 1998 Nov 20; 9(17):2537-44. PubMed ID: 9853520
    [Abstract] [Full Text] [Related]

  • 20. Selectively weakened binding of methotrexate by human dihydrofolate reductase allows rapid ex vivo selection of mammalian cells.
    Volpato JP, Mayotte N, Fossati E, Guerrero V, Sauvageau G, Pelletier JN.
    J Mol Recognit; 2011 Nov 20; 24(2):188-98. PubMed ID: 21360609
    [Abstract] [Full Text] [Related]

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