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391 related items for PubMed ID: 12877591

  • 1. Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands.
    Chambers JJ, Parrish JC, Jensen NH, Kurrasch-Orbaugh DM, Marona-Lewicka D, Nichols DE.
    J Med Chem; 2003 Jul 31; 46(16):3526-35. PubMed ID: 12877591
    [Abstract] [Full Text] [Related]

  • 2. Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity.
    Monte AP, Marona-Lewicka D, Lewis MM, Mailman RB, Wainscott DB, Nelson DL, Nichols DE.
    J Med Chem; 1998 Jun 04; 41(12):2134-45. PubMed ID: 9622555
    [Abstract] [Full Text] [Related]

  • 3. New 5-hydroxytryptamine(1A) receptor ligands containing a norbornene nucleus: synthesis and in vitro pharmacological evaluation.
    Fiorino F, Perissutti E, Severino B, Santagada V, Cirillo D, Terracciano S, Massarelli P, Bruni G, Collavoli E, Renner C, Caliendo G.
    J Med Chem; 2005 Aug 25; 48(17):5495-503. PubMed ID: 16107148
    [Abstract] [Full Text] [Related]

  • 4. Dihydrobenzofuran analogues of hallucinogens. 4. Mescaline derivatives.
    Monte AP, Waldman SR, Marona-Lewicka D, Wainscott DB, Nelson DL, Sanders-Bush E, Nichols DE.
    J Med Chem; 1997 Sep 12; 40(19):2997-3008. PubMed ID: 9301661
    [Abstract] [Full Text] [Related]

  • 5. Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.
    Leopoldo M, Berardi F, Colabufo NA, Contino M, Lacivita E, Niso M, Perrone R, Tortorella V.
    J Med Chem; 2004 Dec 16; 47(26):6616-24. PubMed ID: 15588097
    [Abstract] [Full Text] [Related]

  • 6. 2,3-Dihydro-2-oxo-1H-benzimidazole-1-carboxamides with selective affinity for the 5-HT(4) receptor: synthesis and structure-affinity and structure-activity relationships of a new series of partial agonist and antagonist derivatives.
    Tapia I, Alonso-Cires L, López-Tudanca PL, Mosquera R, Labeaga L, Innerárity A, Orjales A.
    J Med Chem; 1999 Jul 29; 42(15):2870-80. PubMed ID: 10425096
    [Abstract] [Full Text] [Related]

  • 7. New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation.
    Jurczyk S, Kołaczkowski M, Maryniak E, Zajdel P, Pawłowski M, Tatarczyńska E, Kłodzińska A, Chojnacka-Wójcik E, Bojarski AJ, Charakchieva-Minol S, Duszyńska B, Nowak G, Maciag D.
    J Med Chem; 2004 May 06; 47(10):2659-66. PubMed ID: 15115407
    [Abstract] [Full Text] [Related]

  • 8. Cycloalkanecarboxylic esters derived from lysergol, dihydrolysergol-I, and elymoclavine as partial agonists and antagonists at rat 5-HT2A receptors: pharmacological evidence that the indolo[4,3-fg]quinoline system of the ergolines is responsible for high 5-HT2A receptor affinity.
    Pertz HH, Milhahn H, Eich E.
    J Med Chem; 1999 Feb 25; 42(4):659-68. PubMed ID: 10052973
    [Abstract] [Full Text] [Related]

  • 9. Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors.
    Egan C, Grinde E, Dupre A, Roth BL, Hake M, Teitler M, Herrick-Davis K.
    Synapse; 2000 Feb 25; 35(2):144-50. PubMed ID: 10611640
    [Abstract] [Full Text] [Related]

  • 10. 1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists.
    McLean TH, Parrish JC, Braden MR, Marona-Lewicka D, Gallardo-Godoy A, Nichols DE.
    J Med Chem; 2006 Sep 21; 49(19):5794-803. PubMed ID: 16970404
    [Abstract] [Full Text] [Related]

  • 11. 1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), alpha1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics.
    Bojarski AJ, Paluchowska MH, Duszyńska B, Kłodzińska A, Tatarczyńska E, Chojnacka-Wójcik E.
    Bioorg Med Chem; 2005 Mar 15; 13(6):2293-303. PubMed ID: 15727878
    [Abstract] [Full Text] [Related]

  • 12. Enantiospecific synthesis and pharmacological evaluation of a series of super-potent, conformationally restricted 5-HT(2A/2C) receptor agonists.
    Chambers JJ, Kurrasch-Orbaugh DM, Parker MA, Nichols DE.
    J Med Chem; 2001 Mar 15; 44(6):1003-10. PubMed ID: 11300881
    [Abstract] [Full Text] [Related]

  • 13. Differential phospholipase C activation by phenylalkylamine serotonin 5-HT 2A receptor agonists.
    Parrish JC, Braden MR, Gundy E, Nichols DE.
    J Neurochem; 2005 Dec 15; 95(6):1575-84. PubMed ID: 16277614
    [Abstract] [Full Text] [Related]

  • 14. Re-evaluation of lisuride pharmacology: 5-hydroxytryptamine1A receptor-mediated behavioral effects overlap its other properties in rats.
    Marona-Lewicka D, Kurrasch-Orbaugh DM, Selken JR, Cumbay MG, Lisnicchia JG, Nichols DE.
    Psychopharmacology (Berl); 2002 Oct 15; 164(1):93-107. PubMed ID: 12373423
    [Abstract] [Full Text] [Related]

  • 15. Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.
    Glennon RA, Bondarev ML, Khorana N, Young R, May JA, Hellberg MR, McLaughlin MA, Sharif NA.
    J Med Chem; 2004 Nov 18; 47(24):6034-41. PubMed ID: 15537358
    [Abstract] [Full Text] [Related]

  • 16. C-(4,5,6-trimethoxyindan-1-yl)methanamine: a mescaline analogue designed using a homology model of the 5-HT2A receptor.
    McLean TH, Chambers JJ, Parrish JC, Braden MR, Marona-Lewicka D, Kurrasch-Orbaugh D, Nichols DE.
    J Med Chem; 2006 Jul 13; 49(14):4269-74. PubMed ID: 16821786
    [Abstract] [Full Text] [Related]

  • 17. Dihydrobenzofuran analogues of hallucinogens. 3. Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups.
    Monte AP, Marona-Lewicka D, Parker MA, Wainscott DB, Nelson DL, Nichols DE.
    J Med Chem; 1996 Jul 19; 39(15):2953-61. PubMed ID: 8709129
    [Abstract] [Full Text] [Related]

  • 18. Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines.
    Blair JB, Kurrasch-Orbaugh D, Marona-Lewicka D, Cumbay MG, Watts VJ, Barker EL, Nichols DE.
    J Med Chem; 2000 Nov 30; 43(24):4701-10. PubMed ID: 11101361
    [Abstract] [Full Text] [Related]

  • 19. Structure-activity relationships of phenylalkylamines as agonist ligands for 5-HT(2A) receptors.
    Blaazer AR, Smid P, Kruse CG.
    ChemMedChem; 2008 Sep 30; 3(9):1299-309. PubMed ID: 18666267
    [Abstract] [Full Text] [Related]

  • 20. Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists.
    Braden MR, Parrish JC, Naylor JC, Nichols DE.
    Mol Pharmacol; 2006 Dec 30; 70(6):1956-64. PubMed ID: 17000863
    [Abstract] [Full Text] [Related]

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