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115 related items for PubMed ID: 12883474

  • 1. Mechanism of beta 1-integrin-mediated hepatoma cell growth involves p27 and S-phase kinase-associated protein 2.
    Zhang H, Ozaki I, Mizuta T, Yoshimura T, Matsuhashi S, Hisatomi A, Tadano J, Sakai T, Yamamoto K.
    Hepatology; 2003 Aug; 38(2):305-13. PubMed ID: 12883474
    [Abstract] [Full Text] [Related]

  • 2. Troglitazone induces p27Kip1-associated cell-cycle arrest through down-regulating Skp2 in human hepatoma cells.
    Koga H, Harada M, Ohtsubo M, Shishido S, Kumemura H, Hanada S, Taniguchi E, Yamashita K, Kumashiro R, Ueno T, Sata M.
    Hepatology; 2003 May; 37(5):1086-96. PubMed ID: 12717389
    [Abstract] [Full Text] [Related]

  • 3. Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis.
    Masuda TA, Inoue H, Sonoda H, Mine S, Yoshikawa Y, Nakayama K, Nakayama K, Mori M.
    Cancer Res; 2002 Jul 01; 62(13):3819-25. PubMed ID: 12097295
    [Abstract] [Full Text] [Related]

  • 4. Overexpression of integrin beta1 inhibits proliferation of hepatocellular carcinoma cell SMMC-7721 through preventing Skp2-dependent degradation of p27 via PI3K pathway.
    Fu Y, Fang Z, Liang Y, Zhu X, Prins P, Li Z, Wang L, Sun L, Jin J, Yang Y, Zha X.
    J Cell Biochem; 2007 Oct 15; 102(3):704-18. PubMed ID: 17407140
    [Abstract] [Full Text] [Related]

  • 5. ERK-dependent downregulation of Skp2 reduces Myc activity with HGF, leading to inhibition of cell proliferation through a decrease in Id1 expression.
    Li X, Bian Y, Takizawa Y, Hashimoto T, Ikoma T, Tanaka J, Kitamura N, Inagaki Y, Komada M, Tanaka T.
    Mol Cancer Res; 2013 Nov 15; 11(11):1437-47. PubMed ID: 24177224
    [Abstract] [Full Text] [Related]

  • 6. Growth arrest by troglitazone is mediated by p27Kip1 accumulation, which results from dual inhibition of proteasome activity and Skp2 expression in human hepatocellular carcinoma cells.
    Motomura W, Takahashi N, Nagamine M, Sawamukai M, Tanno S, Kohgo Y, Okumura T.
    Int J Cancer; 2004 Jan 01; 108(1):41-6. PubMed ID: 14618613
    [Abstract] [Full Text] [Related]

  • 7. Interferon-gamma inhibits hepatocyte growth factor-stimulated cell proliferation of human bronchial epithelial cells: upregulation of p27(kip1) cyclin-dependent kinase inhibitor.
    Takami K, Takuwa N, Okazaki H, Kobayashi M, Ohtoshi T, Kawasaki S, Dohi M, Yamamoto K, Nakamura T, Tanaka M, Nakahara K, Takuwa Y, Takizawa H.
    Am J Respir Cell Mol Biol; 2002 Feb 01; 26(2):231-8. PubMed ID: 11804875
    [Abstract] [Full Text] [Related]

  • 8. Transforming growth factor-beta 1-induced apoptosis is blocked by beta 1-integrin-mediated mitogen-activated protein kinase activation in human hepatoma cells.
    Zhang H, Ozaki I, Mizuta T, Yoshimura T, Matsuhashi S, Eguchi Y, Yasutake T, Hisatomi A, Sakai T, Yamamoto K.
    Cancer Sci; 2004 Nov 01; 95(11):878-86. PubMed ID: 15546505
    [Abstract] [Full Text] [Related]

  • 9. Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells.
    Han J, Tsukada Y, Hara E, Kitamura N, Tanaka T.
    J Biol Chem; 2005 Sep 09; 280(36):31548-56. PubMed ID: 16014626
    [Abstract] [Full Text] [Related]

  • 10. Oncogenic Ras blocks transforming growth factor-beta-induced cell-cycle arrest by degradation of p27 through a MEK/Erk/SKP2-dependent pathway.
    Schepers H, Wierenga AT, Eggen BJ, Vellenga E.
    Exp Hematol; 2005 Jul 09; 33(7):747-57. PubMed ID: 15963850
    [Abstract] [Full Text] [Related]

  • 11. Regulation of p27 by S-phase kinase-associated protein 2 is associated with aggressiveness in non-small-cell lung cancer.
    Osoegawa A, Yoshino I, Tanaka S, Sugio K, Kameyama T, Yamaguchi M, Maehara Y.
    J Clin Oncol; 2004 Oct 15; 22(20):4165-73. PubMed ID: 15483027
    [Abstract] [Full Text] [Related]

  • 12. TGF-beta1-mediated activations of c-Src and Rac1 modulate levels of cyclins and p27(Kip1) CDK inhibitor in hepatoma cells replated on fibronectin.
    Kim HP, Kim TY, Lee MS, Jong HS, Kim TY, Lee JW, Bang YJ.
    Biochim Biophys Acta; 2005 Mar 22; 1743(1-2):151-61. PubMed ID: 15777850
    [Abstract] [Full Text] [Related]

  • 13. Small interfering RNA targeting of S phase kinase-interacting protein 2 inhibits cell growth of oral cancer cells by inhibiting p27 degradation.
    Kudo Y, Kitajima S, Ogawa I, Kitagawa M, Miyauchi M, Takata T.
    Mol Cancer Ther; 2005 Mar 22; 4(3):471-6. PubMed ID: 15767556
    [Abstract] [Full Text] [Related]

  • 14. Involvement of down-regulation of Cdk2 activity in hepatocyte growth factor-induced cell cycle arrest at G1 in the human hepatocellular carcinoma cell line HepG2.
    Tsukada Y, Tanaka T, Miyazawa K, Kitamura N.
    J Biochem; 2004 Nov 22; 136(5):701-9. PubMed ID: 15632311
    [Abstract] [Full Text] [Related]

  • 15. A novel route for connexin 43 to inhibit cell proliferation: negative regulation of S-phase kinase-associated protein (Skp 2).
    Zhang YW, Nakayama K, Nakayama K, Morita I.
    Cancer Res; 2003 Apr 01; 63(7):1623-30. PubMed ID: 12670914
    [Abstract] [Full Text] [Related]

  • 16. Integrin beta(1A) upregulates p27 protein amount at the post-translational level in human hepatocellular carcinoma cell line SMMC-7721.
    Fu Y, Wang LY, Liang YL, Jin JW, Fang ZY, Zha XL.
    Acta Biochim Biophys Sin (Shanghai); 2006 Aug 01; 38(8):523-30. PubMed ID: 16894473
    [Abstract] [Full Text] [Related]

  • 17. Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2 activity: cell cycle-dependent expression.
    Sugatani J, Osabe M, Kurosawa M, Kitamura N, Ikari A, Miwa M.
    Drug Metab Dispos; 2010 Jan 01; 38(1):177-86. PubMed ID: 19797611
    [Abstract] [Full Text] [Related]

  • 18. Inhibition of F-Box protein p45(SKP2) expression and stabilization of cyclin-dependent kinase inhibitor p27(KIP1) in vitamin D analog-treated cancer cells.
    Lin R, Wang TT, Miller WH, White JH.
    Endocrinology; 2003 Mar 01; 144(3):749-53. PubMed ID: 12586749
    [Abstract] [Full Text] [Related]

  • 19. Beta 1-integrin protects hepatoma cells from chemotherapy induced apoptosis via a mitogen-activated protein kinase dependent pathway.
    Zhang H, Ozaki I, Mizuta T, Matsuhashi S, Yoshimura T, Hisatomi A, Tadano J, Sakai T, Yamamoto K.
    Cancer; 2002 Aug 15; 95(4):896-906. PubMed ID: 12209735
    [Abstract] [Full Text] [Related]

  • 20. Hepatocyte growth factor (HGF) inhibits skeletal muscle cell differentiation: a role for the bHLH protein twist and the cdk inhibitor p27.
    Leshem Y, Spicer DB, Gal-Levi R, Halevy O.
    J Cell Physiol; 2000 Jul 15; 184(1):101-9. PubMed ID: 10825239
    [Abstract] [Full Text] [Related]

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