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Journal Abstract Search

211 related items for PubMed ID: 12885234

  • 1. Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies.
    De Simone G, Menchise V, Omaggio S, Pedone C, Scozzafava A, Supuran CT.
    Biochemistry; 2003 Aug 05; 42(30):9013-21. PubMed ID: 12885234
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  • 2. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ, Almond HR, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Corcoran TW, Giardino EC, Kauffman JA, Lewis JM, de Garavilla L, Haertlein BJ, Maryanoff BE.
    J Med Chem; 2005 Mar 24; 48(6):1984-2008. PubMed ID: 15771442
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  • 3. Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin.
    Baum B, Muley L, Heine A, Smolinski M, Hangauer D, Klebe G.
    J Mol Biol; 2009 Aug 21; 391(3):552-64. PubMed ID: 19520086
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  • 4. Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.
    Nardini M, Pesce A, Rizzi M, Casale E, Ferraccioli R, Balliano G, Milla P, Ascenzi P, Bolognesi M.
    J Mol Biol; 1996 May 24; 258(5):851-9. PubMed ID: 8637015
    [Abstract] [Full Text] [Related]

  • 5. Compounds binding to the S2-S3 pockets of thrombin.
    Nilsson M, Hämäläinen M, Ivarsson M, Gottfries J, Xue Y, Hansson S, Isaksson R, Fex T.
    J Med Chem; 2009 May 14; 52(9):2708-15. PubMed ID: 19371038
    [Abstract] [Full Text] [Related]

  • 6. Tetrahydro-isoquinoline-based factor Xa inhibitors.
    Kucznierz R, Grams F, Leinert H, Marzenell K, Engh RA, von der Saal W.
    J Med Chem; 1998 Dec 03; 41(25):4983-94. PubMed ID: 9836616
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  • 7. Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis.
    Lu T, Markotan T, Coppo F, Tomczuk B, Crysler C, Eisennagel S, Spurlino J, Gremminger L, Soll RM, Giardino EC, Bone R.
    Bioorg Med Chem Lett; 2004 Jul 16; 14(14):3727-31. PubMed ID: 15203151
    [Abstract] [Full Text] [Related]

  • 8. Profiling the structural determinants for the selectivity of representative factor-Xa and thrombin inhibitors using combined ligand-based and structure-based approaches.
    Bhunia SS, Roy KK, Saxena AK.
    J Chem Inf Model; 2011 Aug 22; 51(8):1966-85. PubMed ID: 21761917
    [Abstract] [Full Text] [Related]

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  • 10. Preparation of L-proline based aeruginosin 298-A analogs: optimization of the P1-moiety.
    Wang G, Goyal N, Hopkinson B.
    Bioorg Med Chem Lett; 2009 Jul 15; 19(14):3798-803. PubMed ID: 19447619
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  • 13. Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.
    Krishnan R, Zhang E, Hakansson K, Arni RK, Tulinsky A, Lim-Wilby MS, Levy OE, Semple JE, Brunck TK.
    Biochemistry; 1998 Sep 01; 37(35):12094-103. PubMed ID: 9724521
    [Abstract] [Full Text] [Related]

  • 14. Recruiting Zn2+ to mediate potent, specific inhibition of serine proteases.
    Katz BA, Luong C.
    J Mol Biol; 1999 Sep 24; 292(3):669-84. PubMed ID: 10497030
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  • 17. Structural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutes.
    Bone R, Lu T, Illig CR, Soll RM, Spurlino JC.
    J Med Chem; 1998 Jun 04; 41(12):2068-75. PubMed ID: 9622548
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  • 18. The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: a binding mode for a structurally novel class of inhibitors.
    Chirgadze NY, Sall DJ, Briggs SL, Clawson DK, Zhang M, Smith GF, Schevitz RW.
    Protein Sci; 2000 Jan 04; 9(1):29-36. PubMed ID: 10739244
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  • 19. Human alpha-thrombin inhibition by the highly selective compounds N-ethoxycarbonyl-D-Phe-Pro-alpha-azaLys p-nitrophenyl ester and N-carbobenzoxy-Pro-alpha-azaLys p-nitrophenyl ester: a kinetic, thermodynamic and X-ray crystallographic study.
    De Simone G, Balliano G, Milla P, Gallina C, Giordano C, Tarricone C, Rizzi M, Bolognesi M, Ascenzi P.
    J Mol Biol; 1997 Jun 20; 269(4):558-69. PubMed ID: 9217260
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  • 20. Inhibition of human alpha-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate.
    Skordalakes E, Dodson GG, Green DS, Goodwin CA, Scully MF, Hudson HR, Kakkar VV, Deadman JJ.
    J Mol Biol; 2001 Aug 17; 311(3):549-55. PubMed ID: 11493008
    [Abstract] [Full Text] [Related]

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