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147 related items for PubMed ID: 12902406

  • 1. Suprabasal alpha6beta4 integrin expression in epidermis results in enhanced tumourigenesis and disruption of TGFbeta signalling.
    Owens DM, Romero MR, Gardner C, Watt FM.
    J Cell Sci; 2003 Sep 15; 116(Pt 18):3783-91. PubMed ID: 12902406
    [Abstract] [Full Text] [Related]

  • 2. Suprabasal alpha 5 beta1 integrin expression stimulates formation of epidermal squamous cell carcinomas without disrupting TGFbeta signaling or inducing spindle cell tumors.
    Owens DM, Broad S, Yan X, Benitah SA, Watt FM.
    Mol Carcinog; 2005 Sep 15; 44(1):60-6. PubMed ID: 15924349
    [Abstract] [Full Text] [Related]

  • 3. Smads mediate signaling of the TGFbeta superfamily in normal keratinocytes but are lost during skin chemical carcinogenesis.
    He W, Cao T, Smith DA, Myers TE, Wang XJ.
    Oncogene; 2001 Jan 25; 20(4):471-83. PubMed ID: 11313978
    [Abstract] [Full Text] [Related]

  • 4. Protein kinase Cdelta-mediated phosphorylation of alpha6beta4 is associated with reduced integrin localization to the hemidesmosome and decreased keratinocyte attachment.
    Alt A, Ohba M, Li L, Gartsbein M, Belanger A, Denning MF, Kuroki T, Yuspa SH, Tennenbaum T.
    Cancer Res; 2001 Jun 01; 61(11):4591-8. PubMed ID: 11389095
    [Abstract] [Full Text] [Related]

  • 5. Long-term expansion of human functional epidermal precursor cells: promotion of extensive amplification by low TGF-beta1 concentrations.
    Fortunel NO, Hatzfeld JA, Rosemary PA, Ferraris C, Monier MN, Haydont V, Longuet J, Brethon B, Lim B, Castiel I, Schmidt R, Hatzfeld A.
    J Cell Sci; 2003 Oct 01; 116(Pt 19):4043-52. PubMed ID: 12953061
    [Abstract] [Full Text] [Related]

  • 6. A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis.
    Haase I, Hobbs RM, Romero MR, Broad S, Watt FM.
    J Clin Invest; 2001 Aug 01; 108(4):527-36. PubMed ID: 11518726
    [Abstract] [Full Text] [Related]

  • 7. Loss of alpha6 integrins in keratinocytes leads to an increase in TGFbeta and AP1 signaling and in expression of differentiation genes.
    Rodius S, Indra G, Thibault C, Pfister V, Georges-Labouesse E.
    J Cell Physiol; 2007 Aug 01; 212(2):439-49. PubMed ID: 17474077
    [Abstract] [Full Text] [Related]

  • 8. beta-Catenin and TGFbeta signalling cooperate to maintain a mesenchymal phenotype after FosER-induced epithelial to mesenchymal transition.
    Eger A, Stockinger A, Park J, Langkopf E, Mikula M, Gotzmann J, Mikulits W, Beug H, Foisner R.
    Oncogene; 2004 Apr 08; 23(15):2672-2680. PubMed ID: 14755243
    [Abstract] [Full Text] [Related]

  • 9. Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1.
    Subramanian G, Schwarz RE, Higgins L, McEnroe G, Chakravarty S, Dugar S, Reiss M.
    Cancer Res; 2004 Aug 01; 64(15):5200-11. PubMed ID: 15289325
    [Abstract] [Full Text] [Related]

  • 10. Epidermal α6β4 integrin stimulates the influx of immunosuppressive cells during skin tumor promotion.
    Maalouf SW, Theivakumar S, Owens DM.
    J Dermatol Sci; 2012 May 01; 66(2):108-18. PubMed ID: 22464766
    [Abstract] [Full Text] [Related]

  • 11. Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression.
    Liu ZJ, Xiao M, Balint K, Smalley KS, Brafford P, Qiu R, Pinnix CC, Li X, Herlyn M.
    Cancer Res; 2006 Apr 15; 66(8):4182-90. PubMed ID: 16618740
    [Abstract] [Full Text] [Related]

  • 12. Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes.
    Brennan D, Hu Y, Joubeh S, Choi YW, Whitaker-Menezes D, O'Brien T, Uitto J, Rodeck U, Mahoney MG.
    J Cell Sci; 2007 Mar 01; 120(Pt 5):758-71. PubMed ID: 17284515
    [Abstract] [Full Text] [Related]

  • 13. Smad7 but not Smad6 cooperates with oncogenic ras to cause malignant conversion in a mouse model for squamous cell carcinoma.
    Liu X, Lee J, Cooley M, Bhogte E, Hartley S, Glick A.
    Cancer Res; 2003 Nov 15; 63(22):7760-8. PubMed ID: 14633701
    [Abstract] [Full Text] [Related]

  • 14. Intracellular dynamics of Smad-mediated TGFbeta signaling.
    Greene RM, Nugent P, Mukhopadhyay P, Warner DR, Pisano MM.
    J Cell Physiol; 2003 Nov 15; 197(2):261-71. PubMed ID: 14502566
    [Abstract] [Full Text] [Related]

  • 15. Gadd45a regulates matrix metalloproteinases by suppressing DeltaNp63alpha and beta-catenin via p38 MAP kinase and APC complex activation.
    Hildesheim J, Belova GI, Tyner SD, Zhou X, Vardanian L, Fornace AJ.
    Oncogene; 2004 Mar 11; 23(10):1829-37. PubMed ID: 14647429
    [Abstract] [Full Text] [Related]

  • 16. Adhesion-independent alpha6beta4 integrin clustering is mediated by phosphatidylinositol 3-kinase.
    Gilcrease MZ, Zhou X, Welch K.
    Cancer Res; 2004 Oct 15; 64(20):7395-8. PubMed ID: 15492261
    [Abstract] [Full Text] [Related]

  • 17. Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice.
    Raymond K, Kreft M, Janssen H, Calafat J, Sonnenberg A.
    J Cell Sci; 2005 Mar 01; 118(Pt 5):1045-60. PubMed ID: 15731010
    [Abstract] [Full Text] [Related]

  • 18. The roles of Smad2 and Smad3 in the development of chemically induced skin tumors in mice.
    Tannehill-Gregg SH, Kusewitt DF, Rosol TJ, Weinstein M.
    Vet Pathol; 2004 May 01; 41(3):278-82. PubMed ID: 15133179
    [Abstract] [Full Text] [Related]

  • 19. Smad2 mediates Erk1/2 activation by TGF-beta1 in suspended, but not in adherent, gastric carcinoma cells.
    Lee MS, Ko SG, Kim HP, Kim YB, Lee SY, Kim SG, Jong HS, Kim TY, Lee JW, Bang YJ.
    Int J Oncol; 2004 May 01; 24(5):1229-34. PubMed ID: 15067346
    [Abstract] [Full Text] [Related]

  • 20. Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts.
    Mori Y, Ishida W, Bhattacharyya S, Li Y, Platanias LC, Varga J.
    Arthritis Rheum; 2004 Dec 01; 50(12):4008-21. PubMed ID: 15593186
    [Abstract] [Full Text] [Related]

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