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Journal Abstract Search

232 related items for PubMed ID: 12909621

  • 1. Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein.
    Loo TW, Bartlett MC, Clarke DM.
    J Biol Chem; 2003 Oct 10; 278(41):39706-10. PubMed ID: 12909621
    [Abstract] [Full Text] [Related]

  • 2. Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.
    Loo TW, Clarke DM.
    J Biol Chem; 2001 Aug 24; 276(34):31800-5. PubMed ID: 11429407
    [Abstract] [Full Text] [Related]

  • 3. Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding.
    Loo TW, Bartlett MC, Clarke DM.
    J Biol Chem; 2003 Apr 18; 278(16):13603-6. PubMed ID: 12609990
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  • 4. Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites.
    Loo TW, Bartlett MC, Clarke DM.
    J Biol Chem; 2003 Dec 12; 278(50):50136-41. PubMed ID: 14522974
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  • 5. Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil.
    Loo TW, Clarke DM.
    J Biol Chem; 2001 May 04; 276(18):14972-9. PubMed ID: 11279063
    [Abstract] [Full Text] [Related]

  • 6. Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket.
    Loo TW, Bartlett MC, Clarke DM.
    Biochem J; 2006 Oct 15; 399(2):351-9. PubMed ID: 16813563
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of oxidative cross-linking between engineered cysteine residues at positions 332 in predicted transmembrane segments (TM) 6 and 975 in predicted TM12 of human P-glycoprotein by drug substrates.
    Loo TW, Clarke DM.
    J Biol Chem; 1996 Nov 01; 271(44):27482-7. PubMed ID: 8910331
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  • 8. Identification of residues in the drug-binding domain of human P-glycoprotein. Analysis of transmembrane segment 11 by cysteine-scanning mutagenesis and inhibition by dibromobimane.
    Loo TW, Clarke DM.
    J Biol Chem; 1999 Dec 10; 274(50):35388-92. PubMed ID: 10585407
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  • 10. Permanent activation of the human P-glycoprotein by covalent modification of a residue in the drug-binding site.
    Loo TW, Bartlett MC, Clarke DM.
    J Biol Chem; 2003 Jun 06; 278(23):20449-52. PubMed ID: 12711602
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  • 12. Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.
    Loo TW, Clarke DM.
    J Biol Chem; 2002 Nov 15; 277(46):44332-8. PubMed ID: 12223492
    [Abstract] [Full Text] [Related]

  • 13. Drug-stimulated ATPase activity of human P-glycoprotein requires movement between transmembrane segments 6 and 12.
    Loo TW, Clarke DM.
    J Biol Chem; 1997 Aug 22; 272(34):20986-9. PubMed ID: 9261097
    [Abstract] [Full Text] [Related]

  • 14. Identification of residues in the drug translocation pathway of the human multidrug resistance P-glycoprotein by arginine mutagenesis.
    Loo TW, Bartlett MC, Clarke DM.
    J Biol Chem; 2009 Sep 04; 284(36):24074-87. PubMed ID: 19581304
    [Abstract] [Full Text] [Related]

  • 15. Disulfide cross-linking analysis shows that transmembrane segments 5 and 8 of human P-glycoprotein are close together on the cytoplasmic side of the membrane.
    Loo TW, Bartlett MC, Clarke DM.
    J Biol Chem; 2004 Feb 27; 279(9):7692-7. PubMed ID: 14670948
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  • 18. Introduction of the most common cystic fibrosis mutation (Delta F508) into human P-glycoprotein disrupts packing of the transmembrane segments.
    Loo TW, Bartlett MC, Clarke DM.
    J Biol Chem; 2002 Aug 02; 277(31):27585-8. PubMed ID: 12070134
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  • 20. Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1).
    Chufan EE, Kapoor K, Sim HM, Singh S, Talele TT, Durell SR, Ambudkar SV.
    PLoS One; 2013 Aug 02; 8(12):e82463. PubMed ID: 24349290
    [Abstract] [Full Text] [Related]

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