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217 related items for PubMed ID: 12911316

  • 1. Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation.
    Pickett JS, Bowers KE, Hartman HL, Fu HW, Embry AC, Casey PJ, Fierke CA.
    Biochemistry; 2003 Aug 19; 42(32):9741-8. PubMed ID: 12911316
    [Abstract] [Full Text] [Related]

  • 2. Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate.
    Long SB, Casey PJ, Beese LS.
    Biochemistry; 1998 Jul 07; 37(27):9612-8. PubMed ID: 9657673
    [Abstract] [Full Text] [Related]

  • 3. Positively charged side chains in protein farnesyltransferase enhance catalysis by stabilizing the formation of the diphosphate leaving group.
    Bowers KE, Fierke CA.
    Biochemistry; 2004 May 11; 43(18):5256-65. PubMed ID: 15122891
    [Abstract] [Full Text] [Related]

  • 4. Mechanistic studies of rat protein farnesyltransferase indicate an associative transition state.
    Huang C, Hightower KE, Fierke CA.
    Biochemistry; 2000 Mar 14; 39(10):2593-602. PubMed ID: 10704208
    [Abstract] [Full Text] [Related]

  • 5. Mutagenesis studies of protein farnesyltransferase implicate aspartate beta 352 as a magnesium ligand.
    Pickett JS, Bowers KE, Fierke CA.
    J Biol Chem; 2003 Dec 19; 278(51):51243-50. PubMed ID: 14532266
    [Abstract] [Full Text] [Related]

  • 6. Modulation of the zinc(II) center in protein farnesyltransferase by mutagenesis of the zinc(II) ligands.
    Harris CM, Derdowski AM, Poulter CD.
    Biochemistry; 2002 Aug 20; 41(33):10554-62. PubMed ID: 12173942
    [Abstract] [Full Text] [Related]

  • 7. Protein farnesyltransferase isoprenoid substrate discrimination is dependent on isoprene double bonds and branched methyl groups.
    Micali E, Chehade KA, Isaacs RJ, Andres DA, Spielmann HP.
    Biochemistry; 2001 Oct 16; 40(41):12254-65. PubMed ID: 11591144
    [Abstract] [Full Text] [Related]

  • 8. Farnesyl protein transferase: identification of K164 alpha and Y300 beta as catalytic residues by mutagenesis and kinetic studies.
    Wu Z, Demma M, Strickland CL, Radisky ES, Poulter CD, Le HV, Windsor WT.
    Biochemistry; 1999 Aug 31; 38(35):11239-49. PubMed ID: 10471273
    [Abstract] [Full Text] [Related]

  • 9. Kinetic analysis of zinc ligand mutants of mammalian protein farnesyltransferase.
    Fu HW, Beese LS, Casey PJ.
    Biochemistry; 1998 Mar 31; 37(13):4465-72. PubMed ID: 9521766
    [Abstract] [Full Text] [Related]

  • 10. Computational studies of the farnesyltransferase ternary complex part I: substrate binding.
    Cui G, Wang B, Merz KM.
    Biochemistry; 2005 Dec 20; 44(50):16513-23. PubMed ID: 16342942
    [Abstract] [Full Text] [Related]

  • 11. Interplay of isoprenoid and peptide substrate specificity in protein farnesyltransferase.
    Reigard SA, Zahn TJ, Haworth KB, Hicks KA, Fierke CA, Gibbs RA.
    Biochemistry; 2005 Aug 23; 44(33):11214-23. PubMed ID: 16101305
    [Abstract] [Full Text] [Related]

  • 12. Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release.
    Furfine ES, Leban JJ, Landavazo A, Moomaw JF, Casey PJ.
    Biochemistry; 1995 May 23; 34(20):6857-62. PubMed ID: 7756316
    [Abstract] [Full Text] [Related]

  • 13. H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate.
    Hightower KE, Huang CC, Casey PJ, Fierke CA.
    Biochemistry; 1998 Nov 03; 37(44):15555-62. PubMed ID: 9799520
    [Abstract] [Full Text] [Related]

  • 14. Selective modification of CaaX peptides with ortho-substituted anilinogeranyl lipids by protein farnesyl transferase: competitive substrates and potent inhibitors from a library of farnesyl diphosphate analogues.
    Troutman JM, Subramanian T, Andres DA, Spielmann HP.
    Biochemistry; 2007 Oct 09; 46(40):11310-21. PubMed ID: 17854205
    [Abstract] [Full Text] [Related]

  • 15. Measurement of the alpha-secondary kinetic isotope effect for the reaction catalyzed by mammalian protein farnesyltransferase.
    Pais JE, Bowers KE, Fierke CA.
    J Am Chem Soc; 2006 Nov 29; 128(47):15086-7. PubMed ID: 17117849
    [Abstract] [Full Text] [Related]

  • 16. Photoaffinity analogues of farnesyl pyrophosphate transferable by protein farnesyl transferase.
    Chehade KA, Kiegiel K, Isaacs RJ, Pickett JS, Bowers KE, Fierke CA, Andres DA, Spielmann HP.
    J Am Chem Soc; 2002 Jul 17; 124(28):8206-19. PubMed ID: 12105898
    [Abstract] [Full Text] [Related]

  • 17. Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase.
    Hightower KE, Casey PJ, Fierke CA.
    Biochemistry; 2001 Jan 30; 40(4):1002-10. PubMed ID: 11170422
    [Abstract] [Full Text] [Related]

  • 18. The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
    Long SB, Hancock PJ, Kral AM, Hellinga HW, Beese LS.
    Proc Natl Acad Sci U S A; 2001 Nov 06; 98(23):12948-53. PubMed ID: 11687658
    [Abstract] [Full Text] [Related]

  • 19. Role of metals in the reaction catalyzed by protein farnesyltransferase.
    Saderholm MJ, Hightower KE, Fierke CA.
    Biochemistry; 2000 Oct 10; 39(40):12398-405. PubMed ID: 11015220
    [Abstract] [Full Text] [Related]

  • 20. Conversion of protein farnesyltransferase to a geranylgeranyltransferase.
    Terry KL, Casey PJ, Beese LS.
    Biochemistry; 2006 Aug 15; 45(32):9746-55. PubMed ID: 16893176
    [Abstract] [Full Text] [Related]

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