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384 related items for PubMed ID: 12944410

  • 1. Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells.
    Gunaratnam L, Morley M, Franovic A, de Paulsen N, Mekhail K, Parolin DA, Nakamura E, Lorimer IA, Lee S.
    J Biol Chem; 2003 Nov 07; 278(45):44966-74. PubMed ID: 12944410
    [Abstract] [Full Text] [Related]

  • 2. Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer.
    Smith K, Gunaratnam L, Morley M, Franovic A, Mekhail K, Lee S.
    Cancer Res; 2005 Jun 15; 65(12):5221-30. PubMed ID: 15958567
    [Abstract] [Full Text] [Related]

  • 3. Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.
    Krieg M, Haas R, Brauch H, Acker T, Flamme I, Plate KH.
    Oncogene; 2000 Nov 16; 19(48):5435-43. PubMed ID: 11114720
    [Abstract] [Full Text] [Related]

  • 4. Effect of radiation and ibuprofen on normoxic renal carcinoma cells overexpressing hypoxia-inducible factors by loss of von Hippel-Lindau tumor suppressor gene function.
    Palayoor ST, Burgos MA, Shoaibi A, Tofilon PJ, Coleman CN.
    Clin Cancer Res; 2004 Jun 15; 10(12 Pt 1):4158-64. PubMed ID: 15217953
    [Abstract] [Full Text] [Related]

  • 5. Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.
    de Paulsen N, Brychzy A, Fournier MC, Klausner RD, Gnarra JR, Pause A, Lee S.
    Proc Natl Acad Sci U S A; 2001 Feb 13; 98(4):1387-92. PubMed ID: 11171960
    [Abstract] [Full Text] [Related]

  • 6. Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas.
    Na X, Wu G, Ryan CK, Schoen SR, di'Santagnese PA, Messing EM.
    J Urol; 2003 Aug 13; 170(2 Pt 1):588-92. PubMed ID: 12853836
    [Abstract] [Full Text] [Related]

  • 7. Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma.
    Petrella BL, Lohi J, Brinckerhoff CE.
    Oncogene; 2005 Feb 03; 24(6):1043-52. PubMed ID: 15592504
    [Abstract] [Full Text] [Related]

  • 8. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway.
    Blancher C, Moore JW, Robertson N, Harris AL.
    Cancer Res; 2001 Oct 01; 61(19):7349-55. PubMed ID: 11585776
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.
    Zimmer M, Doucette D, Siddiqui N, Iliopoulos O.
    Mol Cancer Res; 2004 Feb 01; 2(2):89-95. PubMed ID: 14985465
    [Abstract] [Full Text] [Related]

  • 10. Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor.
    Knebelmann B, Ananth S, Cohen HT, Sukhatme VP.
    Cancer Res; 1998 Jan 15; 58(2):226-31. PubMed ID: 9443397
    [Abstract] [Full Text] [Related]

  • 11. Specific oncolytic effect of a new hypoxia-inducible factor-dependent replicative adenovirus on von Hippel-Lindau-defective renal cell carcinomas.
    Cuevas Y, Hernández-Alcoceba R, Aragones J, Naranjo-Suárez S, Castellanos MC, Esteban MA, Martín-Puig S, Landazuri MO, del Peso L.
    Cancer Res; 2003 Oct 15; 63(20):6877-84. PubMed ID: 14583486
    [Abstract] [Full Text] [Related]

  • 12. Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.
    Turner KJ, Moore JW, Jones A, Taylor CF, Cuthbert-Heavens D, Han C, Leek RD, Gatter KC, Maxwell PH, Ratcliffe PJ, Cranston D, Harris AL.
    Cancer Res; 2002 May 15; 62(10):2957-61. PubMed ID: 12019178
    [Abstract] [Full Text] [Related]

  • 13. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas.
    Wiesener MS, Münchenhagen PM, Berger I, Morgan NV, Roigas J, Schwiertz A, Jürgensen JS, Gruber G, Maxwell PH, Löning SA, Frei U, Maher ER, Gröne HJ, Eckardt KU.
    Cancer Res; 2001 Jul 01; 61(13):5215-22. PubMed ID: 11431362
    [Abstract] [Full Text] [Related]

  • 14. Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease.
    Zatyka M, da Silva NF, Clifford SC, Morris MR, Wiesener MS, Eckardt KU, Houlston RS, Richards FM, Latif F, Maher ER.
    Cancer Res; 2002 Jul 01; 62(13):3803-11. PubMed ID: 12097293
    [Abstract] [Full Text] [Related]

  • 15. Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene.
    Liu MY, Poellinger L, Walker CL.
    Cancer Res; 2003 May 15; 63(10):2675-80. PubMed ID: 12750296
    [Abstract] [Full Text] [Related]

  • 16. Identification of novel VHL target genes and relationship to hypoxic response pathways.
    Maina EN, Morris MR, Zatyka M, Raval RR, Banks RE, Richards FM, Johnson CM, Maher ER.
    Oncogene; 2005 Jun 30; 24(28):4549-58. PubMed ID: 15824735
    [Abstract] [Full Text] [Related]

  • 17. TGFBI-promoted adhesion, migration and invasion of human renal cell carcinoma depends on inactivation of von Hippel-Lindau tumor suppressor.
    Shang D, Liu Y, Yang P, Chen Y, Tian Y.
    Urology; 2012 Apr 30; 79(4):966.e1-7. PubMed ID: 22341602
    [Abstract] [Full Text] [Related]

  • 18. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.
    Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ.
    Mol Cell Biol; 2005 Jul 30; 25(13):5675-86. PubMed ID: 15964822
    [Abstract] [Full Text] [Related]

  • 19. Renal cell carcinoma- and pheochromocytoma-specific altered gene expression profiles in VHL mutant clones.
    Tsuchiya MI, Okuda H, Takaki Y, Baba M, Hirai S, Ohno S, Shuin T.
    Oncol Rep; 2005 Jun 30; 13(6):1033-41. PubMed ID: 15870918
    [Abstract] [Full Text] [Related]

  • 20. Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor.
    Zagzag D, Krishnamachary B, Yee H, Okuyama H, Chiriboga L, Ali MA, Melamed J, Semenza GL.
    Cancer Res; 2005 Jul 15; 65(14):6178-88. PubMed ID: 16024619
    [Abstract] [Full Text] [Related]

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