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476 related items for PubMed ID: 12947090

  • 1. Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression.
    Bloom DA, Jaiswal AK.
    J Biol Chem; 2003 Nov 07; 278(45):44675-82. PubMed ID: 12947090
    [Abstract] [Full Text] [Related]

  • 2. Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene.
    Dhakshinamoorthy S, Jaiswal AK.
    Oncogene; 2001 Jun 28; 20(29):3906-17. PubMed ID: 11439354
    [Abstract] [Full Text] [Related]

  • 3. Site-directed mutagenesis of cysteine to serine in the DNA binding region of Nrf2 decreases its capacity to upregulate antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene.
    Bloom D, Dhakshinamoorthy S, Jaiswal AK.
    Oncogene; 2002 Mar 28; 21(14):2191-200. PubMed ID: 11948402
    [Abstract] [Full Text] [Related]

  • 4. Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2.
    Huang HC, Nguyen T, Pickett CB.
    Proc Natl Acad Sci U S A; 2000 Nov 07; 97(23):12475-80. PubMed ID: 11035812
    [Abstract] [Full Text] [Related]

  • 5. Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants.
    Dhakshinamoorthy S, Jain AK, Bloom DA, Jaiswal AK.
    J Biol Chem; 2005 Apr 29; 280(17):16891-900. PubMed ID: 15734732
    [Abstract] [Full Text] [Related]

  • 6. Nrf2 signaling in coordinated activation of antioxidant gene expression.
    Jaiswal AK.
    Free Radic Biol Med; 2004 May 15; 36(10):1199-207. PubMed ID: 15110384
    [Abstract] [Full Text] [Related]

  • 7. Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance.
    Niture SK, Jain AK, Jaiswal AK.
    J Cell Sci; 2009 Dec 15; 122(Pt 24):4452-64. PubMed ID: 19920073
    [Abstract] [Full Text] [Related]

  • 8. Nitric oxide-induced transcriptional up-regulation of protective genes by Nrf2 via the antioxidant response element counteracts apoptosis of neuroblastoma cells.
    Dhakshinamoorthy S, Porter AG.
    J Biol Chem; 2004 May 07; 279(19):20096-107. PubMed ID: 14985350
    [Abstract] [Full Text] [Related]

  • 9. Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap 'n' collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2): cross-interaction between AhR (aryl hydrocarbon receptor) and Nrf2 signal transduction.
    Ma Q, Kinneer K, Bi Y, Chan JY, Kan YW.
    Biochem J; 2004 Jan 01; 377(Pt 1):205-13. PubMed ID: 14510636
    [Abstract] [Full Text] [Related]

  • 10. Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence.
    Nioi P, McMahon M, Itoh K, Yamamoto M, Hayes JD.
    Biochem J; 2003 Sep 01; 374(Pt 2):337-48. PubMed ID: 12816537
    [Abstract] [Full Text] [Related]

  • 11. Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway.
    Qaisiya M, Coda Zabetta CD, Bellarosa C, Tiribelli C.
    Cell Signal; 2014 Mar 01; 26(3):512-20. PubMed ID: 24308969
    [Abstract] [Full Text] [Related]

  • 12. Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress.
    Numazawa S, Ishikawa M, Yoshida A, Tanaka S, Yoshida T.
    Am J Physiol Cell Physiol; 2003 Aug 01; 285(2):C334-42. PubMed ID: 12700136
    [Abstract] [Full Text] [Related]

  • 13. Antioxidant-induced phosphorylation of tyrosine 486 leads to rapid nuclear export of Bach1 that allows Nrf2 to bind to the antioxidant response element and activate defensive gene expression.
    Kaspar JW, Jaiswal AK.
    J Biol Chem; 2010 Jan 01; 285(1):153-62. PubMed ID: 19897490
    [Abstract] [Full Text] [Related]

  • 14. Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals.
    Chen C, Pung D, Leong V, Hebbar V, Shen G, Nair S, Li W, Kong AN.
    Free Radic Biol Med; 2004 Nov 15; 37(10):1578-90. PubMed ID: 15477009
    [Abstract] [Full Text] [Related]

  • 15. Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome.
    Nguyen T, Sherratt PJ, Huang HC, Yang CS, Pickett CB.
    J Biol Chem; 2003 Feb 14; 278(7):4536-41. PubMed ID: 12446695
    [Abstract] [Full Text] [Related]

  • 16. Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors.
    Nioi P, Hayes JD.
    Mutat Res; 2004 Nov 02; 555(1-2):149-71. PubMed ID: 15476858
    [Abstract] [Full Text] [Related]

  • 17. Nrf3 negatively regulates antioxidant-response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene.
    Sankaranarayanan K, Jaiswal AK.
    J Biol Chem; 2004 Dec 03; 279(49):50810-7. PubMed ID: 15385560
    [Abstract] [Full Text] [Related]

  • 18. Nrf2-dependent activation of the antioxidant responsive element by tert-butylhydroquinone is independent of oxidative stress in IMR-32 human neuroblastoma cells.
    Lee JM, Moehlenkamp JD, Hanson JM, Johnson JA.
    Biochem Biophys Res Commun; 2001 Jan 12; 280(1):286-92. PubMed ID: 11162512
    [Abstract] [Full Text] [Related]

  • 19. Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression.
    Kaspar JW, Niture SK, Jaiswal AK.
    J Cell Sci; 2012 Feb 15; 125(Pt 4):1027-38. PubMed ID: 22448038
    [Abstract] [Full Text] [Related]

  • 20. Nuclear import and export signals in control of Nrf2.
    Jain AK, Bloom DA, Jaiswal AK.
    J Biol Chem; 2005 Aug 12; 280(32):29158-68. PubMed ID: 15901726
    [Abstract] [Full Text] [Related]

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