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370 related items for PubMed ID: 12966088

  • 1. Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.
    Lee JH, Ghirlando R, Bhaskara V, Hoffmeyer MR, Gu J, Paull TT.
    J Biol Chem; 2003 Nov 14; 278(46):45171-81. PubMed ID: 12966088
    [Abstract] [Full Text] [Related]

  • 2. Molecular characterization of the Schizosaccharomyces pombe nbs1+ gene involved in DNA repair and telomere maintenance.
    Ueno M, Nakazaki T, Akamatsu Y, Watanabe K, Tomita K, Lindsay HD, Shinagawa H, Iwasaki H.
    Mol Cell Biol; 2003 Sep 14; 23(18):6553-63. PubMed ID: 12944481
    [Abstract] [Full Text] [Related]

  • 3. ATP puts the brake on DNA double-strand break repair: a new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends.
    Hopfner KP.
    Bioessays; 2014 Dec 14; 36(12):1170-8. PubMed ID: 25213441
    [Abstract] [Full Text] [Related]

  • 4. The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint.
    Chahwan C, Nakamura TM, Sivakumar S, Russell P, Rhind N.
    Mol Cell Biol; 2003 Sep 14; 23(18):6564-73. PubMed ID: 12944482
    [Abstract] [Full Text] [Related]

  • 5. Arsenic-induced Mre11 phosphorylation is cell cycle-dependent and defective in NBS cells.
    Yuan SS, Su JH, Hou MF, Yang FW, Zhao S, Lee EY.
    DNA Repair (Amst); 2002 Feb 28; 1(2):137-42. PubMed ID: 12509260
    [Abstract] [Full Text] [Related]

  • 6. Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.
    Williams RS, Dodson GE, Limbo O, Yamada Y, Williams JS, Guenther G, Classen S, Glover JN, Iwasaki H, Russell P, Tainer JA.
    Cell; 2009 Oct 02; 139(1):87-99. PubMed ID: 19804755
    [Abstract] [Full Text] [Related]

  • 7. The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.
    Stracker TH, Morales M, Couto SS, Hussein H, Petrini JH.
    Nature; 2007 May 10; 447(7141):218-21. PubMed ID: 17429352
    [Abstract] [Full Text] [Related]

  • 8. Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis.
    Taylor AM, Groom A, Byrd PJ.
    DNA Repair (Amst); 2004 May 10; 3(8-9):1219-25. PubMed ID: 15279810
    [Abstract] [Full Text] [Related]

  • 9. The Aspergillus nidulans sldI(RAD50) gene interacts with bimE(APC1), a homologue of an anaphase-promoting complex subunit.
    Malavazi I, Lima JF, von Zeska Kress Fagundes MR, Efimov VP, de Souza Goldman MH, Goldman GH.
    Mol Microbiol; 2005 Jul 10; 57(1):222-37. PubMed ID: 15948962
    [Abstract] [Full Text] [Related]

  • 10. Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.
    Lee JH, Xu B, Lee CH, Ahn JY, Song MS, Lee H, Canman CE, Lee JS, Kastan MB, Lim DS.
    Mol Cancer Res; 2003 Jul 10; 1(9):674-81. PubMed ID: 12861053
    [Abstract] [Full Text] [Related]

  • 11. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.
    Lee JH, Mand MR, Deshpande RA, Kinoshita E, Yang SH, Wyman C, Paull TT.
    J Biol Chem; 2013 May 03; 288(18):12840-51. PubMed ID: 23525106
    [Abstract] [Full Text] [Related]

  • 12. Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.
    Cerosaletti K, Concannon P.
    J Biol Chem; 2004 Sep 10; 279(37):38813-9. PubMed ID: 15234984
    [Abstract] [Full Text] [Related]

  • 13. Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.
    Williams RS, Williams JS, Tainer JA.
    Biochem Cell Biol; 2007 Aug 10; 85(4):509-20. PubMed ID: 17713585
    [Abstract] [Full Text] [Related]

  • 14. Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS.
    Shull ER, Lee Y, Nakane H, Stracker TH, Zhao J, Russell HR, Petrini JH, McKinnon PJ.
    Genes Dev; 2009 Jan 15; 23(2):171-80. PubMed ID: 19171781
    [Abstract] [Full Text] [Related]

  • 15. MRX (Mre11/Rad50/Xrs2) mutants reveal dual intra-S-phase checkpoint systems in budding yeast.
    Andrews CA, Clarke DJ.
    Cell Cycle; 2005 Aug 15; 4(8):1073-7. PubMed ID: 15970664
    [Abstract] [Full Text] [Related]

  • 16. Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.
    Limbo O, Moiani D, Kertokalio A, Wyman C, Tainer JA, Russell P.
    Nucleic Acids Res; 2012 Dec 15; 40(22):11435-49. PubMed ID: 23080121
    [Abstract] [Full Text] [Related]

  • 17. The rad50 signature motif: essential to ATP binding and biological function.
    Moncalian G, Lengsfeld B, Bhaskara V, Hopfner KP, Karcher A, Alden E, Tainer JA, Paull TT.
    J Mol Biol; 2004 Jan 23; 335(4):937-51. PubMed ID: 14698290
    [Abstract] [Full Text] [Related]

  • 18. Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling.
    Chen H, Donnianni RA, Handa N, Deng SK, Oh J, Timashev LA, Kowalczykowski SC, Symington LS.
    Proc Natl Acad Sci U S A; 2015 Apr 14; 112(15):E1880-7. PubMed ID: 25831494
    [Abstract] [Full Text] [Related]

  • 19. Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe.
    Li Y, Wang J, Zhou G, Lajeunesse M, Le N, Stawicki BN, Corcino YL, Berkner KL, Runge KW.
    Genetics; 2017 May 14; 206(1):481-496. PubMed ID: 28292918
    [Abstract] [Full Text] [Related]

  • 20. Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.
    Nakada D, Hirano Y, Sugimoto K.
    Mol Cell Biol; 2004 Nov 14; 24(22):10016-25. PubMed ID: 15509802
    [Abstract] [Full Text] [Related]

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