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Journal Abstract Search

123 related items for PubMed ID: 12966161

  • 1. Hair depigmentation is a biological readout for pharmacological inhibition of KIT in mice and humans.
    Moss KG, Toner GC, Cherrington JM, Mendel DB, Laird AD.
    J Pharmacol Exp Ther; 2003 Nov; 307(2):476-80. PubMed ID: 12966161
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  • 3. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.
    Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, Li G, Schreck RE, Abrams TJ, Ngai TJ, Lee LB, Murray LJ, Carver J, Chan E, Moss KG, Haznedar JO, Sukbuntherng J, Blake RA, Sun L, Tang C, Miller T, Shirazian S, McMahon G, Cherrington JM.
    Clin Cancer Res; 2003 Jan; 9(1):327-37. PubMed ID: 12538485
    [Abstract] [Full Text] [Related]

  • 4. Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase.
    Sun L, Liang C, Shirazian S, Zhou Y, Miller T, Cui J, Fukuda JY, Chu JY, Nematalla A, Wang X, Chen H, Sistla A, Luu TC, Tang F, Wei J, Tang C.
    J Med Chem; 2003 Mar 27; 46(7):1116-9. PubMed ID: 12646019
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  • 6. SCF/c-kit signaling is required for cyclic regeneration of the hair pigmentation unit.
    Botchkareva NV, Khlgatian M, Longley BJ, Botchkarev VA, Gilchrest BA.
    FASEB J; 2001 Mar 27; 15(3):645-58. PubMed ID: 11259383
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  • 8. An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients.
    O'Farrell AM, Foran JM, Fiedler W, Serve H, Paquette RL, Cooper MA, Yuen HA, Louie SG, Kim H, Nicholas S, Heinrich MC, Berdel WE, Bello C, Jacobs M, Scigalla P, Manning WC, Kelsey S, Cherrington JM.
    Clin Cancer Res; 2003 Nov 15; 9(15):5465-76. PubMed ID: 14654525
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  • 9. Hair depigmentation during chemotherapy with a class III/V receptor tyrosine kinase inhibitor.
    Routhouska S, Gilliam AC, Mirmirani P.
    Arch Dermatol; 2006 Nov 15; 142(11):1477-9. PubMed ID: 17116839
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  • 10. Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor.
    Morimoto AM, Tan N, West K, McArthur G, Toner GC, Manning WC, Smolich BD, Cherrington JM.
    Oncogene; 2004 Feb 26; 23(8):1618-26. PubMed ID: 14985702
    [Abstract] [Full Text] [Related]

  • 11. SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models.
    Schueneman AJ, Himmelfarb E, Geng L, Tan J, Donnelly E, Mendel D, McMahon G, Hallahan DE.
    Cancer Res; 2003 Jul 15; 63(14):4009-16. PubMed ID: 12873999
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  • 12. Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with "standard of care" therapeutic agents for the treatment of breast cancer.
    Abrams TJ, Murray LJ, Pesenti E, Holway VW, Colombo T, Lee LB, Cherrington JM, Pryer NK.
    Mol Cancer Ther; 2003 Oct 15; 2(10):1011-21. PubMed ID: 14578466
    [Abstract] [Full Text] [Related]

  • 13. Protective effect of Kit signaling for melanocyte stem cells against radiation-induced genotoxic stress.
    Aoki H, Hara A, Motohashi T, Kunisada T.
    J Invest Dermatol; 2011 Sep 15; 131(9):1906-15. PubMed ID: 21633369
    [Abstract] [Full Text] [Related]

  • 14. Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells.
    Krystal GW, Honsawek S, Kiewlich D, Liang C, Vasile S, Sun L, McMahon G, Lipson KE.
    Cancer Res; 2001 May 01; 61(9):3660-8. PubMed ID: 11325836
    [Abstract] [Full Text] [Related]

  • 15. Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis.
    Kumano K, Masuda S, Sata M, Saito T, Lee SY, Sakata-Yanagimoto M, Tomita T, Iwatsubo T, Natsugari H, Kurokawa M, Ogawa S, Chiba S.
    Pigment Cell Melanoma Res; 2008 Feb 01; 21(1):70-8. PubMed ID: 18353145
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  • 16. [4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs.
    Na YJ, Baek HS, Ahn SM, Shin HJ, Chang IS, Hwang JS.
    Biochem Pharmacol; 2007 Sep 01; 74(5):780-6. PubMed ID: 17658483
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  • 17. Topical application of a protein kinase C inhibitor reduces skin and hair pigmentation.
    Park HY, Lee J, González S, Middelkamp-Hup MA, Kapasi S, Peterson S, Gilchrest BA.
    J Invest Dermatol; 2004 Jan 01; 122(1):159-66. PubMed ID: 14962104
    [Abstract] [Full Text] [Related]

  • 18. Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3.
    Teller S, Krämer D, Böhmer SA, Tse KF, Small D, Mahboobi S, Wallrapp C, Beckers T, Kratz-Albers K, Schwäble J, Serve H, Böhmer FD.
    Leukemia; 2002 Aug 01; 16(8):1528-34. PubMed ID: 12145694
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  • 20. The selective class III/V receptor tyrosine kinase inhibitor SU11657 inhibits tumor growth and angiogenesis in experimental neuroblastomas grown in mice.
    Bäckman U, Christofferson R.
    Pediatr Res; 2005 May 01; 57(5 Pt 1):690-5. PubMed ID: 15718357
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