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1078 related items for PubMed ID: 12970779

  • 1. A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells.
    Martelli AM, Tazzari PL, Tabellini G, Bortul R, Billi AM, Manzoli L, Ruggeri A, Conte R, Cocco L.
    Leukemia; 2003 Sep; 17(9):1794-805. PubMed ID: 12970779
    [Abstract] [Full Text] [Related]

  • 2. The phosphoinositide 3-kinase/AKT1 pathway involvement in drug and all-trans-retinoic acid resistance of leukemia cells.
    Neri LM, Borgatti P, Tazzari PL, Bortul R, Cappellini A, Tabellini G, Bellacosa A, Capitani S, Martelli AM.
    Mol Cancer Res; 2003 Jan; 1(3):234-46. PubMed ID: 12556562
    [Abstract] [Full Text] [Related]

  • 3. Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells.
    Tabellini G, Cappellini A, Tazzari PL, Falà F, Billi AM, Manzoli L, Cocco L, Martelli AM.
    J Cell Physiol; 2005 Feb; 202(2):623-34. PubMed ID: 15316930
    [Abstract] [Full Text] [Related]

  • 4. Novel 2'-substituted, 3'-deoxy-phosphatidyl-myo-inositol analogues reduce drug resistance in human leukaemia cell lines with an activated phosphoinositide 3-kinase/Akt pathway.
    Tabellini G, Tazzari PL, Bortul R, Billi AM, Conte R, Manzoli L, Cocco L, Martelli AM.
    Br J Haematol; 2004 Aug; 126(4):574-82. PubMed ID: 15287952
    [Abstract] [Full Text] [Related]

  • 5. Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation.
    Bortul R, Tazzari PL, Cappellini A, Tabellini G, Billi AM, Bareggi R, Manzoli L, Cocco L, Martelli AM.
    Leukemia; 2003 Feb; 17(2):379-89. PubMed ID: 12592338
    [Abstract] [Full Text] [Related]

  • 6. The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.
    Yu C, Rahmani M, Dai Y, Conrad D, Krystal G, Dent P, Grant S.
    Cancer Res; 2003 Apr 15; 63(8):1822-33. PubMed ID: 12702569
    [Abstract] [Full Text] [Related]

  • 7. Serum bioactive lysophospholipids prevent TRAIL-induced apoptosis via PI3K/Akt-dependent cFLIP expression and Bad phosphorylation.
    Kang YC, Kim KM, Lee KS, Namkoong S, Lee SJ, Han JA, Jeoung D, Ha KS, Kwon YG, Kim YM.
    Cell Death Differ; 2004 Dec 15; 11(12):1287-98. PubMed ID: 15297884
    [Abstract] [Full Text] [Related]

  • 8. Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer.
    Chen X, Thakkar H, Tyan F, Gim S, Robinson H, Lee C, Pandey SK, Nwokorie C, Onwudiwe N, Srivastava RK.
    Oncogene; 2001 Sep 20; 20(42):6073-83. PubMed ID: 11593415
    [Abstract] [Full Text] [Related]

  • 9. Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.
    O'Gorman DM, McKenna SL, McGahon AJ, Knox KA, Cotter TG.
    Leukemia; 2000 Apr 20; 14(4):602-11. PubMed ID: 10764145
    [Abstract] [Full Text] [Related]

  • 10. Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell lung cancer cells.
    Kandasamy K, Srivastava RK.
    Cancer Res; 2002 Sep 01; 62(17):4929-37. PubMed ID: 12208743
    [Abstract] [Full Text] [Related]

  • 11. Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance.
    Thakkar H, Chen X, Tyan F, Gim S, Robinson H, Lee C, Pandey SK, Nwokorie C, Onwudiwe N, Srivastava RK.
    J Biol Chem; 2001 Oct 19; 276(42):38361-9. PubMed ID: 11461904
    [Abstract] [Full Text] [Related]

  • 12. Caspase-8 activation is necessary but not sufficient for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in the prostatic carcinoma cell line LNCaP.
    Rokhlin OW, Guseva NV, Tagiyev AF, Glover RA, Cohen MB.
    Prostate; 2002 Jun 01; 52(1):1-11. PubMed ID: 11992615
    [Abstract] [Full Text] [Related]

  • 13. Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells.
    Panka DJ, Mano T, Suhara T, Walsh K, Mier JW.
    J Biol Chem; 2001 Mar 09; 276(10):6893-6. PubMed ID: 11145953
    [Abstract] [Full Text] [Related]

  • 14. Long-term androgen-ablation causes increased resistance to PI3K/Akt pathway inhibition in prostate cancer cells.
    Pfeil K, Eder IE, Putz T, Ramoner R, Culig Z, Ueberall F, Bartsch G, Klocker H.
    Prostate; 2004 Feb 15; 58(3):259-68. PubMed ID: 14743465
    [Abstract] [Full Text] [Related]

  • 15. Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway.
    Zhang J, Choi Y, Mavromatis B, Lichtenstein A, Li W.
    Oncogene; 2003 Sep 18; 22(40):6289-95. PubMed ID: 13679867
    [Abstract] [Full Text] [Related]

  • 16. Regulation of sensitivity to TRAIL by the PTEN tumor suppressor.
    Whang YE, Yuan XJ, Liu Y, Majumder S, Lewis TD.
    Vitam Horm; 2004 Sep 18; 67():409-26. PubMed ID: 15110188
    [Abstract] [Full Text] [Related]

  • 17. Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy.
    Krystal GW, Sulanke G, Litz J.
    Mol Cancer Ther; 2002 Sep 18; 1(11):913-22. PubMed ID: 12481412
    [Abstract] [Full Text] [Related]

  • 18. LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway.
    Poh TW, Pervaiz S.
    Cancer Res; 2005 Jul 15; 65(14):6264-74. PubMed ID: 16024628
    [Abstract] [Full Text] [Related]

  • 19. Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3'-kinase/Akt pathway signaling.
    She QB, Solit D, Basso A, Moasser MM.
    Clin Cancer Res; 2003 Oct 01; 9(12):4340-6. PubMed ID: 14555504
    [Abstract] [Full Text] [Related]

  • 20. Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells.
    St-Germain ME, Gagnon V, Mathieu I, Parent S, Asselin E.
    Int J Oncol; 2004 May 01; 24(5):1311-24. PubMed ID: 15067356
    [Abstract] [Full Text] [Related]

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