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PUBMED FOR HANDHELDS

Journal Abstract Search


164 related items for PubMed ID: 12971796

  • 1. Synthesis and investigation of alpha-hydroxy-N,N-didesmethyltamoxifen as a proximate carcinogen in the metabolic activation of tamoxifen.
    Gamboa da Costa G, Marques MM, Freeman JP, Beland FA.
    Chem Res Toxicol; 2003 Sep; 16(9):1090-8. PubMed ID: 12971796
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  • 6. DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives.
    Gamboa da Costa G, McDaniel-Hamilton LP, Heflich RH, Marques MM, Beland FA.
    Carcinogenesis; 2001 Aug; 22(8):1307-15. PubMed ID: 11470763
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  • 7. alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes.
    Phillips DH, Carmichael PL, Hewer A, Cole KJ, Poon GK.
    Cancer Res; 1994 Nov 01; 54(21):5518-22. PubMed ID: 7923188
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  • 9. Characterization of the major DNA adduct formed by alpha-hydroxy-N-desmethyltamoxifen in vitro and in vivo.
    Gamboa da Costa G, Hamilton LP, Beland FA, Marques MM.
    Chem Res Toxicol; 2000 Mar 01; 13(3):200-7. PubMed ID: 10725117
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  • 11. Hepatic DNA adduct dosimetry in rats fed tamoxifen: a comparison of methods.
    Schild LJ, Phillips DH, Osborne MR, Hewer A, Beland FA, Churchwell MI, Brown K, Gaskell M, Wright E, Poirier MC.
    Mutagenesis; 2005 Mar 01; 20(2):115-24. PubMed ID: 15755801
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  • 17. N-demethylation accompanies alpha-hydroxylation in the metabolic activation of tamoxifen in rat liver cells.
    Phillips DH, Hewer A, Horton MN, Cole KJ, Carmichael PL, Davis W, Osborne MR.
    Carcinogenesis; 1999 Oct 01; 20(10):2003-9. PubMed ID: 10506117
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  • 18. Electrospray ionization-tandem mass spectrometry and 32P-postlabeling analyses of tamoxifen-DNA adducts in humans.
    Beland FA, Churchwell MI, Doerge DR, Parkin DR, Malejka-Giganti D, Hewer A, Phillips DH, Carmichael PL, Gamboa da Costa G, Marques MM.
    J Natl Cancer Inst; 2004 Jul 21; 96(14):1099-104. PubMed ID: 15265972
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  • 19. Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis.
    Tryndyak VP, Muskhelishvili L, Kovalchuk O, Rodriguez-Juarez R, Montgomery B, Churchwell MI, Ross SA, Beland FA, Pogribny IP.
    Carcinogenesis; 2006 Aug 21; 27(8):1713-20. PubMed ID: 16632870
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