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522 related items for PubMed ID: 1312898

  • 21. Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes.
    Yamazaki H, Inui Y, Yun CH, Guengerich FP, Shimada T.
    Carcinogenesis; 1992 Oct; 13(10):1789-94. PubMed ID: 1423839
    [Abstract] [Full Text] [Related]

  • 22. Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes.
    Patten CJ, Smith TJ, Friesen MJ, Tynes RE, Yang CS, Murphy SE.
    Carcinogenesis; 1997 Aug; 18(8):1623-30. PubMed ID: 9276639
    [Abstract] [Full Text] [Related]

  • 23. Quantitation of microsomal alpha-hydroxylation of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
    Peterson LA, Mathew R, Hecht SS.
    Cancer Res; 1991 Oct 15; 51(20):5495-500. PubMed ID: 1913670
    [Abstract] [Full Text] [Related]

  • 24. Tumorigenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers and metabolites in the A/J mouse.
    Upadhyaya P, Kenney PM, Hochalter JB, Wang M, Hecht SS.
    Carcinogenesis; 1999 Aug 15; 20(8):1577-82. PubMed ID: 10426810
    [Abstract] [Full Text] [Related]

  • 25. Induction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) activation in rat lung microsomes by chronic ethanol consumption and repeated running exercise.
    Ardies CM, Smith TJ, Kim S, Yang CS.
    Cancer Lett; 1996 Jun 05; 103(2):209-18. PubMed ID: 8635159
    [Abstract] [Full Text] [Related]

  • 26. Analysis of CYP2A contributions to metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human peripheral lung microsomes.
    Brown PJ, Bedard LL, Reid KR, Petsikas D, Massey TE.
    Drug Metab Dispos; 2007 Nov 05; 35(11):2086-94. PubMed ID: 17717079
    [Abstract] [Full Text] [Related]

  • 27. Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13.
    Jalas JR, Ding X, Murphy SE.
    Drug Metab Dispos; 2003 Oct 05; 31(10):1199-202. PubMed ID: 12975327
    [Abstract] [Full Text] [Related]

  • 28. Effects of citrus phytochemicals on liver and lung cytochrome P450 activity and on the in vitro metabolism of the tobacco-specific nitrosamine NNK.
    Bear WL, Teel RW.
    Anticancer Res; 2000 Oct 05; 20(5A):3323-9. PubMed ID: 11062760
    [Abstract] [Full Text] [Related]

  • 29. Metabolic activation of the tobacco carcinogen 4-(methylnitrosamino)-(3-pyridyl)-1-butanone by cytochrome P450 2A13 in human fetal nasal microsomes.
    Wong HL, Zhang X, Zhang QY, Gu J, Ding X, Hecht SS, Murphy SE.
    Chem Res Toxicol; 2005 Jun 05; 18(6):913-8. PubMed ID: 15962925
    [Abstract] [Full Text] [Related]

  • 30. Identification of critical amino acid residues of human CYP2A13 for the metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen.
    He XY, Shen J, Ding X, Lu AY, Hong JY.
    Drug Metab Dispos; 2004 Dec 05; 32(12):1516-21. PubMed ID: 15333516
    [Abstract] [Full Text] [Related]

  • 31. Inhibitory effects of diallyl sulfide on the metabolism and tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mouse lung.
    Hong JY, Wang ZY, Smith TJ, Zhou S, Shi S, Pan J, Yang CS.
    Carcinogenesis; 1992 May 05; 13(5):901-4. PubMed ID: 1587006
    [Abstract] [Full Text] [Related]

  • 32. Biotransformation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in freshly isolated human lung cells.
    Smith GB, Castonguay A, Donnelly PJ, Reid KR, Petsikas D, Massey TE.
    Carcinogenesis; 1999 Sep 05; 20(9):1809-18. PubMed ID: 10469628
    [Abstract] [Full Text] [Related]

  • 33. 2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: formation of a lung carcinogen precursor.
    Hecht SS, Hochalter JB, Villalta PW, Murphy SE.
    Proc Natl Acad Sci U S A; 2000 Nov 07; 97(23):12493-7. PubMed ID: 11050152
    [Abstract] [Full Text] [Related]

  • 34. Inhibition of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by dietary benzaldehydes.
    Morse MA, Kresty LA, Toburen AL.
    Cancer Lett; 1995 Nov 06; 97(2):255-61. PubMed ID: 7497471
    [Abstract] [Full Text] [Related]

  • 35. Stereoselective metabolism of nicotine and tobacco-specific N-nitrosamines to 4-hydroxy-4-(3-pyridyl)butanoic acid in rats.
    Trushin N, Hecht SS.
    Chem Res Toxicol; 1999 Feb 06; 12(2):164-71. PubMed ID: 10027794
    [Abstract] [Full Text] [Related]

  • 36. Absence of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by flavin-containing monooxygenase (FMO).
    Lamoureux J, Castonguay A.
    Carcinogenesis; 1997 Oct 06; 18(10):1979-84. PubMed ID: 9364009
    [Abstract] [Full Text] [Related]

  • 37. Intestinal metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats: Sex difference, inducibility and inhibition by phenethylisothiocyanate.
    Schulze J, Malone A, Richter E.
    Carcinogenesis; 1995 Aug 06; 16(8):1733-40. PubMed ID: 7634397
    [Abstract] [Full Text] [Related]

  • 38. Characterization of cytochrome P450 2A4 and 2A5-catalyzed 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism.
    Felicia ND, Rekha GK, Murphy SE.
    Arch Biochem Biophys; 2000 Dec 15; 384(2):418-24. PubMed ID: 11368333
    [Abstract] [Full Text] [Related]

  • 39. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human kidney epithelial cells transfected with rat CYP2B1 cDNA.
    Lacroix D, Desrochers M, Castonguay A, Anderson A.
    Carcinogenesis; 1993 Aug 15; 14(8):1639-42. PubMed ID: 8353848
    [Abstract] [Full Text] [Related]

  • 40. Effect of phenethyl isothiocyanate on the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by cultured rat lung tissue.
    Doerr-O'Rourke K, Trushin N, Hecht SS, Stoner GD.
    Carcinogenesis; 1991 Jun 15; 12(6):1029-34. PubMed ID: 2044181
    [Abstract] [Full Text] [Related]

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