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148 related items for PubMed ID: 13129587

  • 1. Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
    Desharnais J, Hwang I, Zhang Y, Tavassoli A, Baboval J, Benkovic SJ, Wilson IA, Boger DL.
    Bioorg Med Chem; 2003 Oct 01; 11(20):4511-21. PubMed ID: 13129587
    [Abstract] [Full Text] [Related]

  • 2. 10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.
    Marsilje TH, Labroli MA, Hedrick MP, Jin Q, Desharnais J, Baker SJ, Gooljarsingh LT, Ramcharan J, Tavassoli A, Zhang Y, Wilson IA, Beardsley GP, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2002 Aug 01; 10(8):2739-49. PubMed ID: 12057663
    [Abstract] [Full Text] [Related]

  • 3. 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.
    Marsilje TH, Hedrick MP, Desharnais J, Capps K, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2003 Oct 01; 11(20):4503-9. PubMed ID: 13129586
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
    Cheng H, Chong Y, Hwang I, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2005 May 16; 13(10):3577-85. PubMed ID: 15848770
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and biological evaluation of alpha- and gamma-carboxamide derivatives of 10-CF3CO-DDACTHF.
    Chong Y, Hwang I, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2005 May 16; 13(10):3587-92. PubMed ID: 15848771
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway.
    Cheng H, Hwang I, Chong Y, Tavassoli A, Webb ME, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2005 May 16; 13(10):3593-9. PubMed ID: 15848772
    [Abstract] [Full Text] [Related]

  • 7. Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
    Marsilje TH, Hedrick MP, Desharnais J, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2003 Oct 01; 11(20):4487-501. PubMed ID: 13129585
    [Abstract] [Full Text] [Related]

  • 8. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.
    Zhang Y, Desharnais J, Marsilje TH, Li C, Hedrick MP, Gooljarsingh LT, Tavassoli A, Benkovic SJ, Olson AJ, Boger DL, Wilson IA.
    Biochemistry; 2003 May 27; 42(20):6043-56. PubMed ID: 12755606
    [Abstract] [Full Text] [Related]

  • 9. Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
    Boger DL, Marsilje TH, Castro RA, Hedrick MP, Jin Q, Baker SJ, Shim JH, Benkovic SJ.
    Bioorg Med Chem Lett; 2000 Jul 03; 10(13):1471-5. PubMed ID: 10888335
    [Abstract] [Full Text] [Related]

  • 10. 10-Formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): a potent inhibitor of glycinamide ribonucleotide transformylase.
    Boger DL, Haynes NE, Kitos PA, Warren MS, Ramcharan J, Marolewski AE, Benkovic SJ.
    Bioorg Med Chem; 1997 Sep 03; 5(9):1817-30. PubMed ID: 9354237
    [Abstract] [Full Text] [Related]

  • 11. Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase.
    Connelly S, DeMartino JK, Boger DL, Wilson IA.
    Biochemistry; 2013 Jul 30; 52(30):5133-44. PubMed ID: 23869564
    [Abstract] [Full Text] [Related]

  • 12. Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-TDAF): an effective inhibitor of glycinamide ribonucleotide transformylase.
    Boger DL, Haynes NE, Warren MS, Ramcharan J, Marolewski AE, Kitos PA, Benkovic SJ.
    Bioorg Med Chem; 1997 Sep 30; 5(9):1847-52. PubMed ID: 9354240
    [Abstract] [Full Text] [Related]

  • 13. Functionalized analogues of 5,8,10-trideazafolate: development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase.
    Boger DL, Haynes NE, Warren MS, Ramcharan J, Kitos PA, Benkovic SJ.
    Bioorg Med Chem; 1997 Sep 30; 5(9):1839-46. PubMed ID: 9354239
    [Abstract] [Full Text] [Related]

  • 14. Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase.
    DeMartino JK, Hwang I, Connelly S, Wilson IA, Boger DL.
    J Med Chem; 2008 Sep 11; 51(17):5441-8. PubMed ID: 18686942
    [Abstract] [Full Text] [Related]

  • 15. Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase.
    Boger DL, Labroli MA, Marsilje TH, Jin Q, Hedrick MP, Baker SJ, Shim JH, Benkovic SJ.
    Bioorg Med Chem; 2000 May 11; 8(5):1075-86. PubMed ID: 10882019
    [Abstract] [Full Text] [Related]

  • 16. Characterization of the enzyme complex involving the folate-requiring enzymes of de novo purine biosynthesis.
    Smith GK, Mueller WT, Wasserman GF, Taylor WD, Benkovic SJ.
    Biochemistry; 1980 Sep 02; 19(18):4313-21. PubMed ID: 7417406
    [Abstract] [Full Text] [Related]

  • 17. Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase.
    Boger DL, Haynes NE, Warren MS, Gooljarsingh LT, Ramcharan J, Kitos PA, Benkovic SJ.
    Bioorg Med Chem; 1997 Sep 02; 5(9):1831-8. PubMed ID: 9354238
    [No Abstract] [Full Text] [Related]

  • 18. Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase.
    DeMartino JK, Hwang I, Xu L, Wilson IA, Boger DL.
    J Med Chem; 2006 May 18; 49(10):2998-3002. PubMed ID: 16686541
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid.
    Kelley JL, McLean EW, Cohn NK, Edelstein MP, Duch DS, Smith GK, Hanlon MH, Ferone R.
    J Med Chem; 1990 Feb 18; 33(2):561-7. PubMed ID: 2299624
    [Abstract] [Full Text] [Related]

  • 20. Human AICAR transformylase: role of the 4-carboxamide of AICAR in binding and catalysis.
    Wall M, Shim JH, Benkovic SJ.
    Biochemistry; 2000 Sep 19; 39(37):11303-11. PubMed ID: 10985775
    [Abstract] [Full Text] [Related]

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