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Journal Abstract Search

133 related items for PubMed ID: 1313879

  • 1. Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase.
    Lau CK, Bélanger PC, Dufresne C, Scheigetz J, Therien M, Fitzsimmons B, Young RN, Ford-Hutchinson AW, Riendeau D, Denis D.
    J Med Chem; 1992 Apr 03; 35(7):1299-318. PubMed ID: 1313879
    [Abstract] [Full Text] [Related]

  • 2. Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.
    Delorme D, Ducharme Y, Brideau C, Chan CC, Chauret N, Desmarais S, Dubé D, Falgueyret JP, Fortin R, Guay J, Hamel P, Jones TR, Lépine C, Li C, McAuliffe M, McFarlane CS, Nicoll-Griffith DA, Riendeau D, Yergey JA, Girard Y.
    J Med Chem; 1996 Sep 27; 39(20):3951-70. PubMed ID: 8831761
    [Abstract] [Full Text] [Related]

  • 3. Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5- benzofuranol, a potent topical antiinflammatory agent.
    Hammond ML, Zambias RA, Chang MN, Jensen NP, McDonald J, Thompson K, Boulton DA, Kopka IE, Hand KM, Opas EE.
    J Med Chem; 1990 Mar 27; 33(3):908-18. PubMed ID: 2308140
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224.
    Lau CK, Bélanger PC, Scheigetz J, Dufresne C, Williams HW, Maycock AL, Guindon Y, Bach T, Dallob AL, Denis D.
    J Med Chem; 1989 Jun 27; 32(6):1190-7. PubMed ID: 2542553
    [Abstract] [Full Text] [Related]

  • 5. Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids.
    Ducharme Y, Brideau C, Dubé D, Chan CC, Falgueyret JP, Gillard JW, Guay J, Hutchinson JH, McFarlane CS, Riendeau D.
    J Med Chem; 1994 Feb 18; 37(4):512-8. PubMed ID: 8120869
    [Abstract] [Full Text] [Related]

  • 6. Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid.
    Hutchinson JH, Riendeau D, Brideau C, Chan C, Falgueyret JP, Guay J, Jones TR, Lépine C, Macdonald D, McFarlane CS.
    J Med Chem; 1994 Apr 15; 37(8):1153-64. PubMed ID: 8164257
    [Abstract] [Full Text] [Related]

  • 7. 2,3-Dihydro-5-benzofuranols as antioxidant-based inhibitors of leukotriene biosynthesis.
    Hammond ML, Kopka IE, Zambias RA, Caldwell CG, Boger J, Baker F, Bach T, Luell S, MacIntyre DE.
    J Med Chem; 1989 May 15; 32(5):1006-20. PubMed ID: 2709371
    [Abstract] [Full Text] [Related]

  • 8. WY-50,295 tromethamine, a novel, orally active 5-lipoxygenase inhibitor: biochemical characterization and antiallergic activity.
    Grimes D, Sturm RJ, Marinari LR, Carlson RP, Berkenkopf JW, Musser JH, Kreft AF, Weichman BM.
    Eur J Pharmacol; 1993 May 19; 236(2):217-28. PubMed ID: 8391458
    [Abstract] [Full Text] [Related]

  • 9. Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor.
    Brideau C, Chan C, Charleson S, Denis D, Evans JF, Ford-Hutchinson AW, Fortin R, Gillard JW, Guay J, Guévremont D.
    Can J Physiol Pharmacol; 1992 Jun 19; 70(6):799-807. PubMed ID: 1330258
    [Abstract] [Full Text] [Related]

  • 10. Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010.
    Hamel P, Riendeau D, Brideau C, Chan CC, Desmarais S, Delorme D, Dubé D, Ducharme Y, Ethier D, Grimm E, Falgueyret JP, Guay J, Jones TR, Kwong E, McAuliffe M, McFarlane CS, Piechuta H, Roumi M, Tagari P, Young RN, Girard Y.
    J Med Chem; 1997 Aug 29; 40(18):2866-75. PubMed ID: 9288168
    [Abstract] [Full Text] [Related]

  • 11. Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816.
    Hutchinson JH, Riendeau D, Brideau C, Chan C, Delorme D, Denis D, Falgueyret JP, Fortin R, Guay J, Hamel P.
    J Med Chem; 1993 Sep 17; 36(19):2771-87. PubMed ID: 8410991
    [Abstract] [Full Text] [Related]

  • 12. 5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.
    Bhatia PA, Brooks CD, Basha A, Ratajczyk JD, Gunn BP, Bouska JB, Lanni C, Young PR, Bell RL, Carter GW.
    J Med Chem; 1996 Sep 27; 39(20):3938-50. PubMed ID: 8831760
    [Abstract] [Full Text] [Related]

  • 13. Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase.
    McMillan RM, Spruce KE, Crawley GC, Walker ER, Foster SJ.
    Br J Pharmacol; 1992 Dec 27; 107(4):1042-7. PubMed ID: 1334748
    [Abstract] [Full Text] [Related]

  • 14. Stimulation of 5-lipoxygenase activity in polymorphonuclear leukocytes of rats by caseinate treatment.
    Chang WC, Su GW.
    Biochem Pharmacol; 1987 Sep 15; 36(18):3033-6. PubMed ID: 2820429
    [Abstract] [Full Text] [Related]

  • 15. L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor.
    Gillard J, Ford-Hutchinson AW, Chan C, Charleson S, Denis D, Foster A, Fortin R, Leger S, McFarlane CS, Morton H.
    Can J Physiol Pharmacol; 1989 May 15; 67(5):456-64. PubMed ID: 2548691
    [Abstract] [Full Text] [Related]

  • 16. L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3- methyl-5-propyl-4-benzofuranol): a novel, selective, orally active 5-lipoxygenase inhibitor.
    Belanger P, Maycock A, Guindon Y, Bach T, Dollob AL, Dufresne C, Ford-Hutchinson AW, Gale PH, Hopple S, Lau CK.
    Can J Physiol Pharmacol; 1987 Dec 15; 65(12):2441-8. PubMed ID: 2835137
    [Abstract] [Full Text] [Related]

  • 17. Pseudoperoxidase activity of 5-lipoxygenase stimulated by potent benzofuranol and N-hydroxyurea inhibitors of the lipoxygenase reaction.
    Riendeau D, Falgueyret JP, Guay J, Ueda N, Yamamoto S.
    Biochem J; 1991 Feb 15; 274 ( Pt 1)(Pt 1):287-92. PubMed ID: 2001245
    [Abstract] [Full Text] [Related]

  • 18. Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase.
    Peduto A, Bruno F, Dehm F, Krauth V, de Caprariis P, Weinigel C, Barz D, Massa A, De Rosa M, Werz O, Filosa R.
    Eur J Med Chem; 2014 Jun 23; 81():492-8. PubMed ID: 24871899
    [Abstract] [Full Text] [Related]

  • 19. Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase: use of the hydroxyurea moiety as a replacement for hydroxamic acid.
    Greco MN, Hageman WE, Powell ET, Tighe JJ, Persico FJ.
    J Med Chem; 1992 Aug 21; 35(17):3180-3. PubMed ID: 1324317
    [Abstract] [Full Text] [Related]

  • 20. Azole phenoxy hydroxyureas as selective and orally active inhibitors of 5-lipoxygenase.
    Malamas MS, Carlson RP, Grimes D, Howell R, Glaser K, Gunawan I, Nelson JA, Kanzelberger M, Shah U, Hartman DA.
    J Med Chem; 1996 Jan 05; 39(1):237-45. PubMed ID: 8568813
    [Abstract] [Full Text] [Related]

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