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148 related items for PubMed ID: 1321910

  • 1. Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains.
    Meanwell NA, Pearce BC, Roth HR, Smith EC, Wedding DL, Wright JJ, Buchanan JO, Baryla UM, Gamberdella M, Gillespie E.
    J Med Chem; 1992 Jul 10; 35(14):2672-87. PubMed ID: 1321910
    [Abstract] [Full Text] [Related]

  • 2. 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation.
    Meanwell NA, Roth HR, Smith EC, Wedding DL, Wright JJ, Fleming JS, Gillespie E.
    J Med Chem; 1991 Sep 10; 34(9):2906-16. PubMed ID: 1654430
    [Abstract] [Full Text] [Related]

  • 3. Inhibitors of blood platelet cAMP phosphodiesterase. 3. 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives with enhanced aqueous solubility.
    Meanwell NA, Dennis RD, Roth HR, Rosenfeld MJ, Smith EC, Wright JJ, Buchanan JO, Brassard CL, Gamberdella M, Gillespie E.
    J Med Chem; 1992 Jul 10; 35(14):2688-96. PubMed ID: 1321911
    [Abstract] [Full Text] [Related]

  • 4. Inhibitors of blood platelet cAMP phosphodiesterase. 4. Structural variation of the side-chain terminus of water-soluble 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives.
    Meanwell NA, Hewawasam P, Thomas JA, Wright JJ, Russell JW, Gamberdella M, Goldenberg HJ, Seiler SM, Zavoico GB.
    J Med Chem; 1993 Oct 29; 36(22):3251-64. PubMed ID: 8230115
    [Abstract] [Full Text] [Related]

  • 5. Imidazoquinoline derivatives: potent inhibitors of platelet cAMP phosphodiesterase which elevate cAMP levels and activate protein kinase in platelets.
    Seiler S, Gillespie E, Arnold AJ, Brassard CL, Meanwell NA, Fleming JS.
    Thromb Res; 1991 Apr 29; 62(1-2):31-42. PubMed ID: 1649498
    [Abstract] [Full Text] [Related]

  • 6. Pharmacology of a potent, new antithrombotic agent, 1,3-dihydro-7,8-dimethyl-2H-imidazo[4,5-b]quinolin-2-one (BMY-20844).
    Buchanan JO, Fleming JS, Cornish BT, Baryla UM, Gillespie E, Stanton HC, Seiler SM, Keely SL.
    Thromb Res; 1989 Nov 01; 56(3):333-46. PubMed ID: 2559492
    [Abstract] [Full Text] [Related]

  • 7. 3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase.
    Martinez GR, Walker KA, Hirschfeld DR, Bruno JJ, Yang DS, Maloney PJ.
    J Med Chem; 1992 Feb 21; 35(4):620-8. PubMed ID: 1311763
    [Abstract] [Full Text] [Related]

  • 8. Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro- 2-oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide (RS-82856).
    Venuti MC, Jones GH, Alvarez R, Bruno JJ.
    J Med Chem; 1987 Feb 21; 30(2):303-18. PubMed ID: 3027339
    [Abstract] [Full Text] [Related]

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  • 10. Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline.
    Venuti MC, Stephenson RA, Alvarez R, Bruno JJ, Strosberg AM.
    J Med Chem; 1988 Nov 21; 31(11):2136-45. PubMed ID: 2846839
    [Abstract] [Full Text] [Related]

  • 11. 7-Bromo-1,5-dihydro-3,6-dimethylimidazo[2,1-b]quinazolin-2(3H)- one (Ro 15-2041), a potent antithrombotic agent that selectively inhibits platelet cyclic AMP-phosphodiesterase.
    Muggli R, Tschopp TB, Mittelholzer E, Baumgartner HR.
    J Pharmacol Exp Ther; 1985 Oct 21; 235(1):212-9. PubMed ID: 2995647
    [Abstract] [Full Text] [Related]

  • 12. Y-590 (a new pyridazinone derivative), a potent anti-thrombotic agent--II. Inhibition of platelet phosphodiesterase.
    Mikashima H, Nakao T, Goto K, Ochi H, Yasuda H, Tsumagari T.
    Thromb Res; 1984 Sep 01; 35(5):589-94. PubMed ID: 6091293
    [Abstract] [Full Text] [Related]

  • 13. Inhibitors of cyclic AMP phosphodiesterase. 1. Analogues of cilostamide and anagrelide.
    Jones GH, Venuti MC, Alvarez R, Bruno JJ, Berks AH, Prince A.
    J Med Chem; 1987 Feb 01; 30(2):295-303. PubMed ID: 3027338
    [Abstract] [Full Text] [Related]

  • 14. Role of plasma adenosine in the antiplatelet action of HL 725, a potent inhibitor of cAMP phosphodiesterase: species differences.
    Agarwal KC, Buckley RS, Parks RE.
    Thromb Res; 1987 Jul 15; 47(2):191-200. PubMed ID: 2821650
    [Abstract] [Full Text] [Related]

  • 15. Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase.
    Dell'Agli M, Maschi O, Galli GV, Fagnani R, Dal Cero E, Caruso D, Bosisio E.
    Br J Nutr; 2008 May 15; 99(5):945-51. PubMed ID: 17927845
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of platelet aggregation by the cAMP-phosphodiesterase inhibitor, cilostamide, may not be associated with activation of cAMP-dependent protein kinase.
    Nishikawa M, Komada F, Morita K, Deguchi K, Shirakawa S.
    Cell Signal; 1992 Jul 15; 4(4):453-63. PubMed ID: 1329900
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  • 18. Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity.
    Sudo T, Tachibana K, Toga K, Tochizawa S, Inoue Y, Kimura Y, Hidaka H.
    Biochem Pharmacol; 2000 Feb 15; 59(4):347-56. PubMed ID: 10644042
    [Abstract] [Full Text] [Related]

  • 19. HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro.
    Ruppert D, Weithmann KU.
    Life Sci; 1982 Nov 08; 31(19):2037-43. PubMed ID: 6294426
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