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6. Mutations in the interglobular domain of aggrecan alter matrix metalloproteinase and aggrecanase cleavage patterns. Evidence that matrix metalloproteinase cleavage interferes with aggrecanase activity. Mercuri FA, Maciewicz RA, Tart J, Last K, Fosang AJ. J Biol Chem; 2000 Oct 20; 275(42):33038-45. PubMed ID: 11032846 [Abstract] [Full Text] [Related]
7. The interglobular domain of cartilage aggrecan is cleaved by hemorrhagic metalloproteinase HT-d (atrolysin C) at the matrix metalloproteinase and aggrecanase sites. Tortorella MD, Pratta MA, Fox JW, Arner EC. J Biol Chem; 1998 Mar 06; 273(10):5846-50. PubMed ID: 9488721 [Abstract] [Full Text] [Related]
17. MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein. Durigova M, Nagase H, Mort JS, Roughley PJ. Matrix Biol; 2011 Mar 25; 30(2):145-53. PubMed ID: 21055468 [Abstract] [Full Text] [Related]
18. Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent. Fosang AJ, Last K, Maciewicz RA. J Clin Invest; 1996 Nov 15; 98(10):2292-9. PubMed ID: 8941646 [Abstract] [Full Text] [Related]
19. Analysis of the catabolism of aggrecan in cartilage explants by quantitation of peptides from the three globular domains. Sandy JD, Boynton RE, Flannery CR. J Biol Chem; 1991 May 05; 266(13):8198-205. PubMed ID: 2022637 [Abstract] [Full Text] [Related]
20. Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH. Handley CJ, Mok MT, Ilic MZ, Adcocks C, Buttle DJ, Robinson HC. Matrix Biol; 2001 Dec 05; 20(8):543-53. PubMed ID: 11731271 [Abstract] [Full Text] [Related] Page: [Next] [New Search]