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Journal Abstract Search

127 related items for PubMed ID: 1331394

  • 1. Mechanism of hepatic microsomal oxidation of 11-hydroxy-delta 8-tetrahydrocannabinol to 11-oxo-delta 8-tetrahydrocannabinol. Evidence for hydration of the aldehyde formed.
    Watanabe K, Matsunaga T, Narimatsu S, Yamamoto I, Yoshimura H.
    J Pharmacobiodyn; 1992 Jun; 15(6):311-7. PubMed ID: 1331394
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  • 2. Enzymatic oxidation of 7-hydroxylated delta 8-tetrahydrocannabinol to 7-oxo-delta 8-tetrahydrocannabinol by hepatic microsomes of the guinea pig.
    Narimatsu S, Matsubara K, Shimonishi T, Watanabe K, Yamamoto I, Yoshimura H.
    Drug Metab Dispos; 1988 Jun; 16(1):156-61. PubMed ID: 2894947
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  • 3. Monkey hepatic microsomal alcohol oxygenase: purification and characterization of a cytochrome P450 enzyme catalyzing the stereoselective oxidation of 7alpha- and 7beta-hydroxy-delta8-tetrahydrocannabinol to 7-oxo-delta8-tetrahydrocannabinol.
    Matsunaga T, Iwawaki Y, Komura A, Watanabe K, Kageyama T, Yamamoto I.
    Biol Pharm Bull; 2002 Jan; 25(1):42-7. PubMed ID: 11824554
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  • 4. CYP3A4 is a major isoform responsible for oxidation of 7-hydroxy-Delta(8)-tetrahydrocannabinol to 7-oxo-delta(8)-tetrahydrocannabinol in human liver microsomes.
    Matsunaga T, Kishi N, Higuchi S, Watanabe K, Ohshima T, Yamamoto I.
    Drug Metab Dispos; 2000 Nov; 28(11):1291-6. PubMed ID: 11038155
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  • 6. Catalytic activity of cytochrome P450 isozymes purified from rat liver in converting 11-oxo-delta 8-tetrahydrocannabinol to delta 8-tetrahydrocannabinol-11-oic acid.
    Watanabe K, Matsunaga T, Narimatsu S, Yamamoto I, Imaoka S, Funae Y, Yoshimura H.
    Biochem Pharmacol; 1991 Aug 22; 42(6):1255-9. PubMed ID: 1653566
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  • 8. Microsomal alcohol oxygenase: purification and characterization of a cytochrome P450 responsible for oxidation of 7-hydroxy-delta 8-tetrahydrocannabinol to 7-oxo-delta 8-tetrahydrocannabinol in guinea pig liver.
    Matsunaga T, Tanaka H, Komura A, Watanabe K, Yamamoto I, Yoshimura H.
    Arch Biochem Biophys; 1997 Dec 01; 348(1):56-64. PubMed ID: 9390174
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  • 9. Oxygenation mechanism in the oxidation of xenobiotic aldehyde to carboxylic acid by mouse hepatic microsomes.
    Yamamoto I, Watanabe K, Narimatsu S, Yoshimura H.
    Biochem Biophys Res Commun; 1988 Jun 16; 153(2):779-82. PubMed ID: 2838024
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  • 10. A cytochrome P450 isozyme having aldehyde oxygenase activity plays a major role in metabolizing cannabinoids by mouse hepatic microsomes.
    Watanabe K, Narimatsu S, Matsunaga T, Yamamoto I, Yoshimura H.
    Biochem Pharmacol; 1993 Aug 03; 46(3):405-11. PubMed ID: 8394082
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  • 14. Sex difference in the oxidative metabolism of delta 9-tetrahydrocannabinol in the rat.
    Narimatsu S, Watanabe K, Yamamoto I, Yoshimura H.
    Biochem Pharmacol; 1991 Apr 15; 41(8):1187-94. PubMed ID: 1848985
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  • 16. Identification and determination of 11-oxo-delta8-tetrahydrocannabinol as an intermediate metabolite of delta8-tetrahydrocannabinol in the mouse brain and liver.
    Watanabe K, Yamamoto I, Oguri K, Yoshimura H.
    J Pharmacobiodyn; 1980 Dec 15; 3(12):686-91. PubMed ID: 6268770
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  • 18. Effect of repeated administration of 11-hydroxy-delta 8-tetrahydrocannabinol, an active metabolite of delta 8-tetrahydrocannabinol, on the hepatic microsomal drug-metabolizing enzyme system of mice.
    Watanabe K, Arai M, Narimatsu S, Yamamoto I, Yoshimura H.
    Biochem Pharmacol; 1986 Jun 01; 35(11):1861-5. PubMed ID: 3013200
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