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Journal Abstract Search

94 related items for PubMed ID: 1338366

  • 1. Quantitative structure-activity relationship study of some benzodiazepine-receptor ligands having inverse agonist/antagonist and agonist actions.
    Sharma RC, Ojha TN, Tiwari S, Singh P.
    Drug Des Discov; 1992; 9(2):135-43. PubMed ID: 1338366
    [Abstract] [Full Text] [Related]

  • 2. Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors.
    Cox ED, Diaz-Arauzo H, Huang Q, Reddy MS, Ma C, Harris B, McKernan R, Skolnick P, Cook JM.
    J Med Chem; 1998 Jul 02; 41(14):2537-52. PubMed ID: 9651158
    [Abstract] [Full Text] [Related]

  • 3. Studies of molecular pharmacophore/receptor models for GABAA/benzodiazepine receptor subtypes: binding affinities of substituted beta-carbolines at recombinant alpha x beta 3 gamma 2 subtypes and quantitative structure-activity relationship studies via a comparative molecular field analysis.
    Huang Q, Cox ED, Gan T, Ma C, Bennett DW, McKernan RM, Cook JM.
    Drug Des Discov; 1999 Jul 02; 16(1):55-76. PubMed ID: 10466057
    [Abstract] [Full Text] [Related]

  • 4. Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site.
    Allen MS, Tan YC, Trudell ML, Narayanan K, Schindler LR, Martin MJ, Schultz C, Hagen TJ, Koehler KF, Codding PW.
    J Med Chem; 1990 Sep 02; 33(9):2343-57. PubMed ID: 2167977
    [Abstract] [Full Text] [Related]

  • 5. Comparative quantitative structure-activity relationship studies (QSAR) on non-benzodiazepine compounds binding to benzodiazepine receptor (BzR).
    Hadjipavlou-Litina D, Garg R, Hansch C.
    Chem Rev; 2004 Sep 02; 104(9):3751-94. PubMed ID: 15352779
    [No Abstract] [Full Text] [Related]

  • 6. Synthesis of substituted 7,12-dihydropyrido[3,2-b:5,4-b']diindoles: rigid planar benzodiazepine receptor ligands with inverse agonist/antagonist properties.
    Trudell ML, Lifer SL, Tan YC, Martin MJ, Deng L, Skolnick P, Cook JM.
    J Med Chem; 1990 Sep 02; 33(9):2412-20. PubMed ID: 2167978
    [Abstract] [Full Text] [Related]

  • 7. Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester.
    Hollinshead SP, Trudell ML, Skolnick P, Cook JM.
    J Med Chem; 1990 Mar 02; 33(3):1062-9. PubMed ID: 1968513
    [Abstract] [Full Text] [Related]

  • 8. 3D and quantum QSAR of non-benzodiazepine compounds.
    Pasha FA, Muddassar M, Cho SJ, Ahmad K, Beg Y.
    Eur J Med Chem; 2008 Nov 02; 43(11):2361-72. PubMed ID: 18346822
    [Abstract] [Full Text] [Related]

  • 9. Development of a comprehensive pharmacophore model for the benzodiazepine receptor.
    Zhang W, Koehler KF, Zhang P, Cook JM.
    Drug Des Discov; 1995 Jan 02; 12(3):193-248. PubMed ID: 7662830
    [Abstract] [Full Text] [Related]

  • 10. Molecular structure of Ro15-1788 and a model for the binding of benzodiazepine receptor ligands. Structural identification of common features in antagonists.
    Codding PW, Muir AK.
    Mol Pharmacol; 1985 Aug 02; 28(2):178-84. PubMed ID: 2991738
    [Abstract] [Full Text] [Related]

  • 11. Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore.
    Allen MS, Hagen TJ, Trudell ML, Codding PW, Skolnick P, Cook JM.
    J Med Chem; 1988 Sep 02; 31(9):1854-61. PubMed ID: 2842507
    [Abstract] [Full Text] [Related]

  • 12. Quantitative structure-activity relationship studies on benzodiazepine receptor binding: recognition of active sites in receptor and modelling of interaction.
    Gupta SP, Saha RN, Mulchandani V.
    J Mol Recognit; 1992 Jun 02; 5(2):75-80. PubMed ID: 1335277
    [Abstract] [Full Text] [Related]

  • 13. Studies of molecular pharmacophore/receptor models for GABAA/BzR subtypes: binding affinities of symmetrically substituted pyrazolo[4,3-c]quinolin-3-ones at recombinant alpha x beta 3 gamma 2 subtypes and quantitative structure-activity relationship studies via a comparative molecular field analysis.
    He X, Huang Q, Yu S, Ma C, McKernan R, Cook JM.
    Drug Des Discov; 1999 Jul 02; 16(1):77-91. PubMed ID: 10466058
    [Abstract] [Full Text] [Related]

  • 14. Theoretical structure-activity studies of beta-carboline analogs. Requirements for benzodiazepine receptor affinity and antagonist activity.
    Loew GH, Nienow J, Lawson JA, Toll L, Uyeno ET.
    Mol Pharmacol; 1985 Jul 02; 28(1):17-31. PubMed ID: 2862573
    [Abstract] [Full Text] [Related]

  • 15. Stereochemical features controlling binding and intrinsic activity properties of benzodiazepine-receptor ligands.
    Borea PA, Gilli G, Bertolasi V, Ferretti V.
    Mol Pharmacol; 1987 Apr 02; 31(4):334-44. PubMed ID: 3033465
    [Abstract] [Full Text] [Related]

  • 16. Bidirectional effects of benzodiazepine binding site ligands in the passive avoidance task: differential antagonism by flumazenil and beta-CCt.
    Savić MM, Obradović DI, Ugresić ND, Cook JM, Yin W, Bokonjić DR.
    Behav Brain Res; 2005 Mar 30; 158(2):293-300. PubMed ID: 15698896
    [Abstract] [Full Text] [Related]

  • 17. 3D-pharmacophores of flavonoid binding at the benzodiazepine GABA(A) receptor site using 4D-QSAR analysis.
    Hong X, Hopfinger AJ.
    J Chem Inf Comput Sci; 2003 Mar 30; 43(1):324-36. PubMed ID: 12546568
    [Abstract] [Full Text] [Related]

  • 18. 2-H- and 2-acyl-9- [omega-[4-(2-methoxyphenyl)piperazinyl]-alkyl]-1,2,3,4-tetrahydro-beta-carbolines as ligands of 5-HT1A and 5-HT2A receptors.
    Boksa J, Mokrosz MJ, Charakchieva-Minol S, Tatarczyńska E, Kłodzińska A, Wesołowska A, Misztal S.
    Pol J Pharmacol; 2001 Mar 30; 53(5):501-8. PubMed ID: 11990069
    [Abstract] [Full Text] [Related]

  • 19. Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse.
    Yin W, Majumder S, Clayton T, Petrou S, VanLinn ML, Namjoshi OA, Ma C, Cromer BA, Roth BL, Platt DM, Cook JM.
    Bioorg Med Chem; 2010 Nov 01; 18(21):7548-64. PubMed ID: 20888240
    [Abstract] [Full Text] [Related]

  • 20. Identification of novel short chain 4-substituted indoles as potent alphavbeta3 antagonist using structure-based drug design.
    Raboisson P, Desjarlais RL, Reed R, Lattanze J, Chaikin M, Manthey CL, Tomczuk BE, Marugán JJ.
    Eur J Med Chem; 2007 Mar 01; 42(3):334-43. PubMed ID: 17184884
    [Abstract] [Full Text] [Related]

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