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184 related items for PubMed ID: 1378915

  • 1. Enzyme studies of methotrexate-resistant human leukemic cell (K562) subclones.
    Koizumi S, Allegra CJ.
    Leuk Res; 1992; 16(6-7):565-9. PubMed ID: 1378915
    [Abstract] [Full Text] [Related]

  • 2. Biological activity and intracellular metabolism of ZD1694 in human leukemia cell lines with different resistance mechanisms to antifolate drugs.
    Takemura Y, Kobayashi H, Miyachi H, Gibson W, Kimbell R, Jackman AL.
    Jpn J Cancer Res; 1996 Jul; 87(7):773-80. PubMed ID: 8698629
    [Abstract] [Full Text] [Related]

  • 3. Cytotoxicity of trimetrexate against antifolate-resistant human T-cell leukemia cell lines developed in oxidized or reduced folate.
    Miyachi H, Takemura Y, Kobayashi H, Ando Y.
    Jpn J Cancer Res; 1997 Sep; 88(9):900-6. PubMed ID: 9369939
    [Abstract] [Full Text] [Related]

  • 4. Expression of variant dihydrofolate reductase with decreased binding affinity to antifolates in MOLT-3 human leukemia cell lines resistant to trimetrexate.
    Miyachi H, Takemura Y, Kobayashi H, Ando Y.
    Cancer Lett; 1995 Jan 06; 88(1):93-9. PubMed ID: 7850779
    [Abstract] [Full Text] [Related]

  • 5. Decreased expression of the human folate receptor mediates transport-defective methotrexate resistance in KB cells.
    Saikawa Y, Knight CB, Saikawa T, Page ST, Chabner BA, Elwood PC.
    J Biol Chem; 1993 Mar 05; 268(7):5293-301. PubMed ID: 7680349
    [Abstract] [Full Text] [Related]

  • 6. Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
    Mauritz R, Peters GJ, Priest DG, Assaraf YG, Drori S, Kathmann I, Noordhuis P, Bunni MA, Rosowsky A, Schornagel JH, Pinedo HM, Jansen G.
    Biochem Pharmacol; 2002 Jan 15; 63(2):105-15. PubMed ID: 11841783
    [Abstract] [Full Text] [Related]

  • 7. Impairment of methotrexate (MTX)-polyglutamate formation of MTX-resistant K562 cell lines.
    Koizumi S.
    Jpn J Cancer Res; 1988 Nov 15; 79(11):1230-7. PubMed ID: 2465288
    [Abstract] [Full Text] [Related]

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  • 10. Folate transport and the modulation of antifolate sensitivity in a methotrexate-resistant human breast cancer cell line.
    Dixon KH, Trepel JB, Eng SC, Cowan KH.
    Cancer Commun; 1991 Nov 15; 3(12):357-65. PubMed ID: 16296001
    [Abstract] [Full Text] [Related]

  • 11. Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
    Diddens H, Niethammer D, Jackson RC.
    Cancer Res; 1983 Nov 15; 43(11):5286-92. PubMed ID: 6225514
    [Abstract] [Full Text] [Related]

  • 12. A methotrexate-resistant human breast cancer cell line with multiple defects, including diminished formation of methotrexate polyglutamates.
    Cowan KH, Jolivet J.
    J Biol Chem; 1984 Sep 10; 259(17):10793-800. PubMed ID: 6206061
    [Abstract] [Full Text] [Related]

  • 13. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate.
    Senkovich O, Schormann N, Chattopadhyay D.
    Acta Crystallogr D Biol Crystallogr; 2009 Jul 10; 65(Pt 7):704-16. PubMed ID: 19564691
    [Abstract] [Full Text] [Related]

  • 14. Intrinsic resistance of cervical squamous cell carcinoma cell lines to methotrexate (MTX) as a result of decreased accumulation of intracellular MTX polyglutamates.
    Barakat RR, Li WW, Lovelace C, Bertino JR.
    Gynecol Oncol; 1993 Oct 10; 51(1):54-60. PubMed ID: 7694891
    [Abstract] [Full Text] [Related]

  • 15. Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line.
    Schuetz JD, Matherly LH, Westin EH, Goldman ID.
    J Biol Chem; 1988 Jul 15; 263(20):9840-7. PubMed ID: 2838483
    [Abstract] [Full Text] [Related]

  • 16. Large diversity in transport-mediated methotrexate resistance in human leukemia cell line CCRF-CEM established in a high concentration of leucovorin.
    Asai S, Miyachi H, Kobayashi H, Takemura Y, Ando Y.
    Cancer Sci; 2003 Feb 15; 94(2):210-4. PubMed ID: 12708499
    [Abstract] [Full Text] [Related]

  • 17. Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transport.
    Matherly LH, Angeles SM, McGuire JJ.
    Biochem Pharmacol; 1993 Dec 14; 46(12):2185-95. PubMed ID: 7506026
    [Abstract] [Full Text] [Related]

  • 18. Biochemical and pharmacologic rationale for high-dose methotrexate.
    Jolivet J.
    NCI Monogr; 1987 Dec 14; (5):61-5. PubMed ID: 2448656
    [Abstract] [Full Text] [Related]

  • 19. Inherent resistance of human squamous carcinoma cell lines to methotrexate as a result of decreased polyglutamylation of this drug.
    Pizzorno G, Chang YM, McGuire JJ, Bertino JR.
    Cancer Res; 1989 Oct 01; 49(19):5275-80. PubMed ID: 2475246
    [Abstract] [Full Text] [Related]

  • 20. Differential alterations of dihydrofolate reductase gene in human leukemia cell lines made resistant to various folate analogues.
    Miyachi H, Takemura Y, Kobayashi H, Ando K, Ando Y.
    Jpn J Cancer Res; 1993 Jan 01; 84(1):9-12. PubMed ID: 8449831
    [Abstract] [Full Text] [Related]

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