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Journal Abstract Search

85 related items for PubMed ID: 1404239

  • 1. N-(1-oxododecyl)-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol: a potent competitive inhibitor of 2,3-oxidosqualene cyclase.
    Wannamaker MW, Waid PP, Van Sickle WA, McCarthy JR, Wilson PK, Schatzman GL, Moore WR.
    J Med Chem; 1992 Sep 18; 35(19):3581-3. PubMed ID: 1404239
    [No Abstract] [Full Text] [Related]

  • 2. Potent inhibition of cholesterol biosynthesis in 3T3 fibroblasts by N-[(1,5,9)-trimethyldecyl]-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol, a new 2,3-oxidosqualene cyclase inhibitor.
    Gerst N, Duriatti A, Schuber F, Taton M, Benveniste P, Rahier A.
    Biochem Pharmacol; 1988 May 15; 37(10):1955-64. PubMed ID: 3377803
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  • 4. An alternative mechanism for the inhibition of cholesterol biosynthesis in HepG2 cells by N-[(1,5,9)-trimethyldecyl]-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol (MDL 28,815).
    Van Sickle WA, Wilson PK, Wannamaker MW, Cooper JR, Flanagan MA, McCarthy JR, Bey P, Jackson RL.
    J Pharmacol Exp Ther; 1993 Dec 15; 267(3):1243-9. PubMed ID: 8263786
    [Abstract] [Full Text] [Related]

  • 5. Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives.
    Barth MM, Binet JL, Thomas DM, de Fornel DC, Samreth S, Schuber FJ, Renaut PP.
    J Med Chem; 1996 Jun 07; 39(12):2302-12. PubMed ID: 8691425
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  • 7. Effects of a 2,3-oxidosqualene-lanosterol cyclase inhibitor 2,3:22,23-dioxidosqualene and 24,25-epoxycholesterol on the regulation of cholesterol biosynthesis in human hepatoma cell line HepG2.
    Dollis D, Schuber F.
    Biochem Pharmacol; 1994 Jul 05; 48(1):49-57. PubMed ID: 8043030
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  • 8. Inhibition of cholesterol biosynthesis in Chinese hamster ovary cells by 4,4,10 beta-trimethyl-trans-decal-3 beta-ol. A specific 2,3-oxidosqualene cyclase inhibitor.
    Chang TY, Schiavoni ES, McCrae KR, Nelson JA, Spencer TA.
    J Biol Chem; 1979 Nov 25; 254(22):11258-63. PubMed ID: 500643
    [No Abstract] [Full Text] [Related]

  • 9. Inhibitory activity of 8-azadecalin derivatives towards 2,3-oxidosqualene:lanosterol cyclases from baker's yeast and pig's liver.
    Hoshino T, Kobayashi N, Ishibashi E, Hashimoto S.
    Biosci Biotechnol Biochem; 1995 Apr 25; 59(4):602-9. PubMed ID: 7772824
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  • 10. Structure activity relationships of new inhibitors of mammalian 2,3-oxidosqualene cyclase designed from isoquinoline derivatives.
    Binet J, Thomas D, Benmbarek A, de FD, Renaut P.
    Chem Pharm Bull (Tokyo); 2002 Mar 25; 50(3):316-29. PubMed ID: 11911193
    [Abstract] [Full Text] [Related]

  • 11. Design, synthesis and in vitro evaluation of pyridinium ion based cyclase inhibitors and antifungal agents.
    Rose IC, Sharpe BA, Lee RC, Griffin JH, Capobianco JO, Zakula D, Goldman RC.
    Bioorg Med Chem; 1996 Jan 25; 4(1):97-103. PubMed ID: 8689245
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  • 12. Stereospecific syntheses of trans-vinyldioxidosqualene and 3-hydroxysulfide derivatives, as potent and time-dependent 2,3-oxidosqualene cyclase inhibitors.
    Viola F, Balliano G, Milla P, Cattel L, Rocco F, Ceruti M.
    Bioorg Med Chem; 2000 Jan 25; 8(1):223-32. PubMed ID: 10968281
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  • 13. Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase.
    Galli U, Oliaro-Bosso S, Taramino S, Venegoni S, Pastore E, Tron GC, Balliano G, Viola F, Sorba G.
    Bioorg Med Chem Lett; 2007 Jan 01; 17(1):220-4. PubMed ID: 17027267
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  • 15. Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase.
    Stach D, Zheng YF, Perez AL, Oehlschlager AC, Abe I, Prestwich GD, Hartman PG.
    J Med Chem; 1997 Jan 17; 40(2):201-9. PubMed ID: 9003518
    [Abstract] [Full Text] [Related]

  • 16. Novel 4-piperidinopyridine inhibitors of oxidosqualene cyclase-lanosterol synthase derived by consideration of inhibitor pK(a).
    Brown GR, Foubister AJ, Johnson MC, Newcombe NJ, Waterson D, Wells SL.
    Bioorg Med Chem Lett; 2001 Aug 20; 11(16):2213-6. PubMed ID: 11514173
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  • 17. Inhibition of 2,3-oxidosqualene cyclases.
    Taton M, Benveniste P, Rahier A, Johnson WS, Liu HT, Sudhakar AR.
    Biochemistry; 1992 Sep 01; 31(34):7892-8. PubMed ID: 1510977
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  • 19. Inhibition of 2,3-oxidosqualene: beta-amyrin-cyclase, S-adenosyl-L-methionine: cycloartenol C-24-methyltransferase and cycloeucalenol: obtusifoliol isomerase by rationally designed molecules containing a tertiary amine function.
    Rahier A, Bouvier P, Cattel L, Narula A, Benveniste P.
    Biochem Soc Trans; 1983 Oct 01; 11(5):537-43. PubMed ID: 6642064
    [Abstract] [Full Text] [Related]

  • 20. Inhibition of cholesterol biosynthesis in 3T3 fibroblasts by 2-aza-2,3-dihydrosqualene, a rationally designed 2,3-oxidosqualene cyclase inhibitor.
    Gerst N, Schuber F, Viola F, Cattel L.
    Biochem Pharmacol; 1986 Dec 01; 35(23):4243-50. PubMed ID: 3790151
    [Abstract] [Full Text] [Related]

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