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167 related items for PubMed ID: 1447735

  • 1. Synthesis and biological evaluation of conformationally restricted 2-(1-pyrrolidinyl)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methylethylenediam ines as sigma receptor ligands. 1. Pyrrolidine, piperidine, homopiperidine, and tetrahydroisoquinoline classes.
    de Costa BR, Dominguez C, He XS, Williams W, Radesca L, Bowen W.
    J Med Chem; 1992 Nov 13; 35(23):4334-43. PubMed ID: 1447735
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  • 2. Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes.
    de Costa BR, Rice KC, Bowen WD, Thurkauf A, Rothman RB, Band L, Jacobson AE, Radesca L, Contreras PC, Gray NM.
    J Med Chem; 1990 Nov 13; 33(11):3100-10. PubMed ID: 2172538
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  • 3. Synthesis and evaluation of conformationally restricted N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamines at sigma receptors. 2. Piperazines, bicyclic amines, bridged bicyclic amines, and miscellaneous compounds.
    de Costa BR, He XS, Linders JT, Dominguez C, Gu ZQ, Williams W, Bowen WD.
    J Med Chem; 1993 Aug 06; 36(16):2311-20. PubMed ID: 8360875
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  • 7. Synthesis and receptor binding properties of fluoro- and iodo-substituted high affinity sigma receptor ligands: identification of potential PET and SPECT sigma receptor imaging agents.
    de Costa B, Radesca L, Dominguez C, Di Paolo L, Bowen WD.
    J Med Chem; 1992 Jun 12; 35(12):2221-30. PubMed ID: 1319493
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  • 11. Differentiation of sigma ligand-activated receptor subtypes that modulate NMDA-evoked [3H]-noradrenaline release in rat hippocampal slices.
    Monnet FP, de Costa BR, Bowen WD.
    Br J Pharmacol; 1996 Sep 12; 119(1):65-72. PubMed ID: 8872358
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  • 12. Rat liver and kidney contain high densities of sigma 1 and sigma 2 receptors: characterization by ligand binding and photoaffinity labeling.
    Hellewell SB, Bruce A, Feinstein G, Orringer J, Williams W, Bowen WD.
    Eur J Pharmacol; 1994 Jun 15; 268(1):9-18. PubMed ID: 7925616
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  • 16. Synthesis, in vitro validation and in vivo pharmacokinetics of [125I]N-[2-(4-iodophenyl)ethyl]-N-methyl-2-(1-piperidinyl) ethylamine: a high-affinity ligand for imaging sigma receptor positive tumors.
    John CS, Gulden ME, Vilner BJ, Bowen WD.
    Nucl Med Biol; 1996 Aug 15; 23(6):761-6. PubMed ID: 8940718
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  • 17. Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-binding sites.
    He XS, Raymon LP, Mattson MV, Eldefrawi ME, de Costa BR.
    J Med Chem; 1993 Apr 30; 36(9):1188-93. PubMed ID: 8098066
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