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Journal Abstract Search

242 related items for PubMed ID: 14521415

  • 1. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.
    Daugan A, Grondin P, Ruault C, Le Monnier de Gouville AC, Coste H, Linget JM, Kirilovsky J, Hyafil F, Labaudinière R.
    J Med Chem; 2003 Oct 09; 46(21):4533-42. PubMed ID: 14521415
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  • 2. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues.
    Daugan A, Grondin P, Ruault C, Le Monnier de Gouville AC, Coste H, Kirilovsky J, Hyafil F, Labaudinière R.
    J Med Chem; 2003 Oct 09; 46(21):4525-32. PubMed ID: 14521414
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  • 3. Potent tetracyclic guanine inhibitors of PDE1 and PDE5 cyclic guanosine monophosphate phosphodiesterases with oral antihypertensive activity.
    Ahn HS, Bercovici A, Boykow G, Bronnenkant A, Chackalamannil S, Chow J, Cleven R, Cook J, Czarniecki M, Domalski C, Fawzi A, Green M, Gündes A, Ho G, Laudicina M, Lindo N, Ma K, Manna M, McKittrick B, Mirzai B, Nechuta T, Neustadt B, Puchalski C, Pula K, Zhang H.
    J Med Chem; 1997 Jul 04; 40(14):2196-210. PubMed ID: 9216839
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  • 4. PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil.
    Beghyn T, Hounsou C, Deprez BP.
    Bioorg Med Chem Lett; 2007 Feb 01; 17(3):789-92. PubMed ID: 17107795
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  • 7. Synthesis and evaluation of polycyclic pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP phosphodiesterase inhibitors.
    Xia Y, Chackalamannil S, Czarniecki M, Tsai H, Vaccaro H, Cleven R, Cook J, Fawzi A, Watkins R, Zhang H.
    J Med Chem; 1997 Dec 19; 40(26):4372-7. PubMed ID: 9435906
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  • 8. Highly potent and selective chiral inhibitors of PDE5: an illustration of Pfeiffer's rule.
    Bunnage ME, Mathias JP, Wood A, Miller D, Street SD.
    Bioorg Med Chem Lett; 2008 Dec 01; 18(23):6033-6. PubMed ID: 18951784
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  • 9. A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization.
    Blount MA, Zoraghi R, Ke H, Bessay EP, Corbin JD, Francis SH.
    Mol Pharmacol; 2006 Nov 01; 70(5):1822-31. PubMed ID: 16926278
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  • 10. Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke.
    Zhang L, Zhang Z, Zhang RL, Cui Y, LaPointe MC, Silver B, Chopp M.
    Brain Res; 2006 Nov 06; 1118(1):192-8. PubMed ID: 16959227
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  • 13. Testosterone regulates PDE5 expression and in vivo responsiveness to tadalafil in rat corpus cavernosum.
    Zhang XH, Morelli A, Luconi M, Vignozzi L, Filippi S, Marini M, Vannelli GB, Mancina R, Forti G, Maggi M.
    Eur Urol; 2005 Mar 06; 47(3):409-16; discussion 416. PubMed ID: 15716209
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  • 14. Molecular modeling studies of pyridopurinone derivatives--potential phosphodiesterase 5 inhibitors.
    Srivani P, Srinivas E, Raghu R, Sastry GN.
    J Mol Graph Model; 2007 Jul 06; 26(1):378-90. PubMed ID: 17307372
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  • 15. Substituted pyrazolopyridopyridazines as orally bioavailable potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction.
    Yu G, Mason H, Wu X, Wang J, Chong S, Beyer B, Henwood A, Pongrac R, Seliger L, He B, Normandin D, Ferrer P, Zhang R, Adam L, Humphrey WG, Krupinski J, Macor JE.
    J Med Chem; 2003 Feb 13; 46(4):457-60. PubMed ID: 12570368
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  • 16. Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.
    Bi Y, Stoy P, Adam L, He B, Krupinski J, Normandin D, Pongrac R, Seliger L, Watson A, Macor JE.
    Bioorg Med Chem Lett; 2004 Mar 22; 14(6):1577-80. PubMed ID: 15006407
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  • 17. Furoyl and benzofuroyl pyrroloquinolones as potent and selective PDE5 inhibitors for treatment of erectile dysfunction.
    Jiang W, Sui Z, Macielag MJ, Walsh SP, Fiordeliso JJ, Lanter JC, Guan J, Qiu Y, Kraft P, Bhattacharjee S, Craig E, Haynes-Johnson D, John TM, Clancy J.
    J Med Chem; 2003 Jan 30; 46(3):441-4. PubMed ID: 12540243
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  • 18. 3D-QSAR studies on sildenafil analogues, selective phosphodiesterase 5 inhibitors.
    Yoo J, Thai KM, Kim DK, Lee JY, Park HJ.
    Bioorg Med Chem Lett; 2007 Aug 01; 17(15):4271-4. PubMed ID: 17553682
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  • 19. Synthesis and phosphodiesterase 5 inhibitory activity of new sildenafil analogues containing a phosphonate group in the 5(')-sulfonamide moiety of phenyl ring.
    Kim DK, Young Lee J, Park HJ, Minh Thai K.
    Bioorg Med Chem Lett; 2004 May 03; 14(9):2099-103. PubMed ID: 15080987
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  • 20. Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity as potential agents for treatment of erectile dysfunction.
    Giovannoni MP, Vergelli C, Biancalani C, Cesari N, Graziano A, Biagini P, Gracia J, Gavaldà A, Dal Piaz V.
    J Med Chem; 2006 Aug 24; 49(17):5363-71. PubMed ID: 16913726
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