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Journal Abstract Search

118 related items for PubMed ID: 14565776

  • 1. Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro.
    Williams DP, O'Donnell CJ, Maggs JL, Leeder JS, Uetrecht J, Pirmohamed M, Park BK.
    Chem Res Toxicol; 2003 Oct; 16(10):1359-64. PubMed ID: 14565776
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  • 3. The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man.
    Maggs JL, Williams D, Pirmohamed M, Park BK.
    J Pharmacol Exp Ther; 1995 Dec; 275(3):1463-75. PubMed ID: 8531117
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  • 7. Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: possible role in agranulocytosis.
    Williams DP, Pirmohamed M, Naisbitt DJ, Maggs JL, Park BK.
    J Pharmacol Exp Ther; 1997 Dec; 283(3):1375-82. PubMed ID: 9400013
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  • 8. Clozapine bioactivation induces dose-dependent, drug-specific toxicity of human bone marrow stromal cells: a potential in vitro system for the study of agranulocytosis.
    Pereira A, Dean B.
    Biochem Pharmacol; 2006 Sep 14; 72(6):783-93. PubMed ID: 16844094
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  • 9. Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.
    Zhuo X, Zhao W, Zheng J, Humphreys WG, Shu YZ, Zhu M.
    Chem Biol Interact; 2009 Oct 07; 181(2):227-35. PubMed ID: 19576871
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  • 10. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
    Chen Q, Doss GA, Tung EC, Liu W, Tang YS, Braun MP, Didolkar V, Strauss JR, Wang RW, Stearns RA, Evans DC, Baillie TA, Tang W.
    Drug Metab Dispos; 2006 Jan 07; 34(1):145-51. PubMed ID: 16251255
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  • 12. Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s.
    Wen B, Ma L, Zhu M.
    Chem Biol Interact; 2008 May 09; 173(1):59-67. PubMed ID: 18359012
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  • 14. Covalent binding of procainamide in vitro and in vivo to hepatic protein in mice.
    Freeman RW, Uetrecht JP, Woosley RL, Oates JA, Harbison RD.
    Drug Metab Dispos; 1981 May 09; 9(3):188-92. PubMed ID: 6166442
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  • 15. Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells.
    Liu ZC, Uetrecht JP.
    J Pharmacol Exp Ther; 1995 Dec 09; 275(3):1476-83. PubMed ID: 8531118
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  • 17. Bioactivation of clozapine by mitochondria of the murine heart: Possible cause of cardiotoxicity.
    Arzuk E, Karakuş F, Orhan H.
    Toxicology; 2021 Jan 15; 447():152628. PubMed ID: 33166605
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