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165 related items for PubMed ID: 1457345

  • 1. Enhancement of the cytotoxicity of SR 4233 to normal and malignant tissues by hypoxic breathing.
    Minchinton AI, Brown JM.
    Br J Cancer; 1992 Dec; 66(6):1053-8. PubMed ID: 1457345
    [Abstract] [Full Text] [Related]

  • 2. Comparison of in vivo efficacy of hypoxic cytotoxin tirapazamine and hypoxic cell radiosensitizer KU-2285 in combination with single and fractionated irradiation.
    Shibata T, Shibamoto Y, Sasai K, Oya N, Murata R, Takagi T, Hiraoka M, Abe M.
    Jpn J Cancer Res; 1996 Jan; 87(1):98-104. PubMed ID: 8609056
    [Abstract] [Full Text] [Related]

  • 3. SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours.
    Brown JM.
    Br J Cancer; 1993 Jun; 67(6):1163-70. PubMed ID: 8512801
    [Abstract] [Full Text] [Related]

  • 4. Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233.
    Zeman EM, Hirst VK, Lemmon MJ, Brown JM.
    Radiother Oncol; 1988 Jul; 12(3):209-18. PubMed ID: 3175048
    [Abstract] [Full Text] [Related]

  • 5. SR 4233: a tumor specific radiosensitizer active in fractionated radiation regimes.
    Brown JM, Lemmon MJ.
    Radiother Oncol; 1991 Jul; 20 Suppl 1():151-6. PubMed ID: 2020764
    [Abstract] [Full Text] [Related]

  • 6. Reoxygenation and rehypoxiation in the SCCVII mouse tumor.
    Kim IH, Brown JM.
    Int J Radiat Oncol Biol Phys; 1994 Jun 15; 29(3):493-7. PubMed ID: 8005805
    [Abstract] [Full Text] [Related]

  • 7. Comparison of the enhancement of tumor responses to fractionated irradiation by SR 4233 (tirapazamine) and by nicotinamide with carbogen.
    Dorie MJ, Menke D, Brown JM.
    Int J Radiat Oncol Biol Phys; 1994 Jan 01; 28(1):145-50. PubMed ID: 8270435
    [Abstract] [Full Text] [Related]

  • 8. Interaction of SR-4233 with hyperthermia and radiation in the FSaIIC murine fibrosarcoma tumor system in vitro and in vivo.
    Herman TS, Teicher BA, Coleman CN.
    Cancer Res; 1990 Aug 15; 50(16):5055-9. PubMed ID: 2379171
    [Abstract] [Full Text] [Related]

  • 9. Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. I. Tirapazamine.
    Olive PL.
    Br J Cancer; 1995 Mar 15; 71(3):529-36. PubMed ID: 7880735
    [Abstract] [Full Text] [Related]

  • 10. SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells.
    Zeman EM, Brown JM, Lemmon MJ, Hirst VK, Lee WW.
    Int J Radiat Oncol Biol Phys; 1986 Jul 15; 12(7):1239-42. PubMed ID: 3744945
    [Abstract] [Full Text] [Related]

  • 11. Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model.
    Kyle AH, Minchinton AI.
    Cancer Chemother Pharmacol; 1999 Jul 15; 43(3):213-20. PubMed ID: 9923551
    [Abstract] [Full Text] [Related]

  • 12. Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation.
    Brown JM, Lemmon MJ.
    Int J Radiat Oncol Biol Phys; 1991 Mar 15; 20(3):457-61. PubMed ID: 1995531
    [Abstract] [Full Text] [Related]

  • 13. Second-generation 1,2,4-benzotriazine 1,4-di-N-oxide bioreductive anti-tumor agents: pharmacology and activity in vitro and in vivo.
    Minchinton AI, Lemmon MJ, Tracy M, Pollart DJ, Martinez AP, Tosto LM, Brown JM.
    Int J Radiat Oncol Biol Phys; 1992 Mar 15; 22(4):701-5. PubMed ID: 1544841
    [Abstract] [Full Text] [Related]

  • 14. Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro.
    Siim BG, van Zijl PL, Brown JM.
    Br J Cancer; 1996 Apr 15; 73(8):952-60. PubMed ID: 8611431
    [Abstract] [Full Text] [Related]

  • 15. Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317.
    Siim BG, Pruijn FB, Sturman JR, Hogg A, Hay MP, Brown JM, Wilson WR.
    Cancer Res; 2004 Jan 15; 64(2):736-42. PubMed ID: 14744792
    [Abstract] [Full Text] [Related]

  • 16. Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice.
    Walton MI, Workman P.
    J Pharmacol Exp Ther; 1993 May 15; 265(2):938-47. PubMed ID: 8496834
    [Abstract] [Full Text] [Related]

  • 17. Aerobic radiosensitization by SR 4233 in vitro and in vivo.
    Zeman EM, Lemmon MJ, Brown JM.
    Int J Radiat Oncol Biol Phys; 1990 Jan 15; 18(1):125-32. PubMed ID: 2298615
    [Abstract] [Full Text] [Related]

  • 18. Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors.
    Brown JM, Lemmon MJ.
    Cancer Res; 1990 Dec 15; 50(24):7745-9. PubMed ID: 2253217
    [Abstract] [Full Text] [Related]

  • 19. The effect of pH on the aerobic and hypoxic cytotoxicity of SR4233 in HT-29 cells.
    Skarsgard LD, Skwarchuk MW, Vinczan A, Chaplin DJ.
    Br J Cancer; 1993 Oct 15; 68(4):681-3. PubMed ID: 8398693
    [Abstract] [Full Text] [Related]

  • 20. Carbogen breathing after irradiation enhances the effectiveness of tirapazamine in SiHa tumors but not SCCVII tumors in mice.
    Minchinton AI, Tonn DA, Sutherland DP, Kyle AH.
    Radiat Res; 2002 Jul 15; 158(1):94-100. PubMed ID: 12071808
    [Abstract] [Full Text] [Related]


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