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232 related items for PubMed ID: 14579029

  • 1. MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632.
    Gual P, Grémeaux T, Gonzalez T, Le Marchand-Brustel Y, Tanti JF.
    Diabetologia; 2003 Nov; 46(11):1532-42. PubMed ID: 14579029
    [Abstract] [Full Text] [Related]

  • 2. Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway.
    Ueno M, Carvalheira JB, Tambascia RC, Bezerra RM, Amaral ME, Carneiro EM, Folli F, Franchini KG, Saad MJ.
    Diabetologia; 2005 Mar; 48(3):506-18. PubMed ID: 15692808
    [Abstract] [Full Text] [Related]

  • 3. Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes.
    Tremblay F, Gagnon A, Veilleux A, Sorisky A, Marette A.
    Endocrinology; 2005 Mar; 146(3):1328-37. PubMed ID: 15576463
    [Abstract] [Full Text] [Related]

  • 4. Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes.
    Engelman JA, Berg AH, Lewis RY, Lisanti MP, Scherer PE.
    Mol Endocrinol; 2000 Oct; 14(10):1557-69. PubMed ID: 11043572
    [Abstract] [Full Text] [Related]

  • 5. Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes.
    Gao Z, Zhang X, Zuberi A, Hwang D, Quon MJ, Lefevre M, Ye J.
    Mol Endocrinol; 2004 Aug; 18(8):2024-34. PubMed ID: 15143153
    [Abstract] [Full Text] [Related]

  • 6. Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes.
    Gual P, Gonzalez T, Grémeaux T, Barres R, Le Marchand-Brustel Y, Tanti JF.
    J Biol Chem; 2003 Jul 18; 278(29):26550-7. PubMed ID: 12730242
    [Abstract] [Full Text] [Related]

  • 7. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
    Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB.
    Proc Natl Acad Sci U S A; 2001 Apr 10; 98(8):4640-5. PubMed ID: 11287630
    [Abstract] [Full Text] [Related]

  • 8. Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes.
    Egawa K, Nakashima N, Sharma PM, Maegawa H, Nagai Y, Kashiwagi A, Kikkawa R, Olefsky JM.
    Endocrinology; 2000 Jun 10; 141(6):1930-5. PubMed ID: 10830273
    [Abstract] [Full Text] [Related]

  • 9. Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells.
    Andreozzi F, Laratta E, Sciacqua A, Perticone F, Sesti G.
    Circ Res; 2004 May 14; 94(9):1211-8. PubMed ID: 15044323
    [Abstract] [Full Text] [Related]

  • 10. Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of rapamycin/p70 S6 kinase (S6K1) pathway and serine phosphorylation of insulin receptor substrate-1: effect of reduced expression of p85alpha subunit of phosphatidylinositol 3-kinase and S6K1 kinase.
    Adochio R, Leitner JW, Hedlund R, Draznin B.
    Endocrinology; 2009 Mar 14; 150(3):1165-73. PubMed ID: 18948408
    [Abstract] [Full Text] [Related]

  • 11. Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes.
    Müssig K, Fiedler H, Staiger H, Weigert C, Lehmann R, Schleicher ED, Häring HU.
    Biochem Biophys Res Commun; 2005 Sep 30; 335(3):819-25. PubMed ID: 16099431
    [Abstract] [Full Text] [Related]

  • 12. Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes.
    Bouzakri K, Roques M, Gual P, Espinosa S, Guebre-Egziabher F, Riou JP, Laville M, Le Marchand-Brustel Y, Tanti JF, Vidal H.
    Diabetes; 2003 Jun 30; 52(6):1319-25. PubMed ID: 12765939
    [Abstract] [Full Text] [Related]

  • 13. Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes.
    Fujishiro M, Gotoh Y, Katagiri H, Sakoda H, Ogihara T, Anai M, Onishi Y, Ono H, Abe M, Shojima N, Fukushima Y, Kikuchi M, Oka Y, Asano T.
    Mol Endocrinol; 2003 Mar 30; 17(3):487-97. PubMed ID: 12554784
    [Abstract] [Full Text] [Related]

  • 14. Involvement of the actin network in insulin signalling.
    Tsakiridis T, Wang Q, Taha C, Grinstein S, Downey G, Klip A.
    Soc Gen Physiol Ser; 1997 Mar 30; 52():257-71. PubMed ID: 9210235
    [Abstract] [Full Text] [Related]

  • 15. A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.
    Haruta T, Uno T, Kawahara J, Takano A, Egawa K, Sharma PM, Olefsky JM, Kobayashi M.
    Mol Endocrinol; 2000 Jun 30; 14(6):783-94. PubMed ID: 10847581
    [Abstract] [Full Text] [Related]

  • 16. Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes.
    He J, Usui I, Ishizuka K, Kanatani Y, Hiratani K, Iwata M, Bukhari A, Haruta T, Sasaoka T, Kobayashi M.
    Mol Endocrinol; 2006 Jan 30; 20(1):114-24. PubMed ID: 16150868
    [Abstract] [Full Text] [Related]

  • 17. Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes.
    Hers I, Tavaré JM.
    Biochem J; 2005 Jun 01; 388(Pt 2):713-20. PubMed ID: 15713122
    [Abstract] [Full Text] [Related]

  • 18. Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation.
    Greene MW, Sakaue H, Wang L, Alessi DR, Roth RA.
    J Biol Chem; 2003 Mar 07; 278(10):8199-211. PubMed ID: 12510059
    [Abstract] [Full Text] [Related]

  • 19. Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin.
    Takano A, Usui I, Haruta T, Kawahara J, Uno T, Iwata M, Kobayashi M.
    Mol Cell Biol; 2001 Aug 07; 21(15):5050-62. PubMed ID: 11438661
    [Abstract] [Full Text] [Related]

  • 20. Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells.
    Batty IH, Fleming IN, Downes CP.
    Biochem J; 2004 May 01; 379(Pt 3):641-51. PubMed ID: 14769130
    [Abstract] [Full Text] [Related]

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