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121 related items for PubMed ID: 14584934

  • 1. Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile.
    Wu YJ, He H, Hu S, Huang Y, Scola PM, Grant-Young K, Bertekap RL, Wu D, Gao Q, Li Y, Klakouski C, Westphal RS.
    J Med Chem; 2003 Nov 06; 46(23):4834-7. PubMed ID: 14584934
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  • 3. Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists.
    Ivachtchenko AV, Golovina ES, Kadieva MG, Kysil VM, Mitkin OD, Tkachenko SE, Okun IM.
    J Med Chem; 2011 Dec 08; 54(23):8161-73. PubMed ID: 22029285
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  • 5. Synthesis and SAR of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-HT6 receptor antagonists.
    Ivachtchenko AV, Golovina ES, Kadieva MG, Kysil VM, Mitkin OD, Tkachenko SE, Okun I.
    Bioorg Med Chem; 2011 Feb 15; 19(4):1482-91. PubMed ID: 21277782
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  • 12. Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT₆ receptor antagonist showing activity in rat social recognition test.
    Tripathy R, McHugh RJ, Bacon ER, Salvino JM, Morton GC, Aimone LD, Huang Z, Mathiasen JR, DiCamillo A, Huffman MJ, McKenna BA, Kopec K, Lu LD, Qian J, Angeles TS, Connors T, Spais C, Holskin B, Duzic E, Schaffhauser H, Rossé GC.
    Bioorg Med Chem Lett; 2012 Feb 01; 22(3):1421-6. PubMed ID: 22226656
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  • 13. Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry.
    Corbett DF, Heightman TD, Moss SF, Bromidge SM, Coggon SA, Longley MJ, Roa AM, Williams JA, Thomas DR.
    Bioorg Med Chem Lett; 2005 Sep 15; 15(18):4014-8. PubMed ID: 16002289
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  • 15. Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists.
    Ivachtchenko AV, Frolov EB, Mitkin OD, Kysil VM, Khvat AV, Okun IM, Tkachenko SE.
    Bioorg Med Chem Lett; 2009 Jun 15; 19(12):3183-7. PubMed ID: 19443217
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  • 17. Synthesis and evaluation of 5-HT(2A) and 5-HT(2C) receptor binding affinities of novel pyrimidine derivatives.
    Bózsing D, Simonek I, Simig G, Jakóczi I, Gacsályi I, Lévay G, Tihanyi K, Schmidt E.
    Bioorg Med Chem Lett; 2002 Nov 04; 12(21):3097-9. PubMed ID: 12372510
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