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Journal Abstract Search

343 related items for PubMed ID: 14584944

  • 1. Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials.
    O'Neill PM, Mukhtar A, Stocks PA, Randle LE, Hindley S, Ward SA, Storr RC, Bickley JF, O'Neil IA, Maggs JL, Hughes RH, Winstanley PA, Bray PG, Park BK.
    J Med Chem; 2003 Nov 06; 46(23):4933-45. PubMed ID: 14584944
    [Abstract] [Full Text] [Related]

  • 2. Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.
    O'Neill PM, Shone AE, Stanford D, Nixon G, Asadollahy E, Park BK, Maggs JL, Roberts P, Stocks PA, Biagini G, Bray PG, Davies J, Berry N, Hall C, Rimmer K, Winstanley PA, Hindley S, Bambal RB, Davis CB, Bates M, Gresham SL, Brigandi RA, Gomez-de-Las-Heras FM, Gargallo DV, Parapini S, Vivas L, Lander H, Taramelli D, Ward SA.
    J Med Chem; 2009 Apr 09; 52(7):1828-44. PubMed ID: 19284751
    [Abstract] [Full Text] [Related]

  • 3. Replacement of the 4'-hydroxy group of amodiaquine and amopyroquine by aromatic and aliphatic substituents: synthesis and antimalarial activity.
    Păunescu E, Susplugas S, Boll E, Varga R, Mouray E, Grosu I, Grellier P, Melnyk P.
    ChemMedChem; 2009 Apr 09; 4(4):549-61. PubMed ID: 19212949
    [Abstract] [Full Text] [Related]

  • 4. Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.
    O'Neill PM, Park BK, Shone AE, Maggs JL, Roberts P, Stocks PA, Biagini GA, Bray PG, Gibbons P, Berry N, Winstanley PA, Mukhtar A, Bonar-Law R, Hindley S, Bambal RB, Davis CB, Bates M, Hart TK, Gresham SL, Lawrence RM, Brigandi RA, Gomez-delas-Heras FM, Gargallo DV, Ward SA.
    J Med Chem; 2009 Mar 12; 52(5):1408-15. PubMed ID: 19222165
    [Abstract] [Full Text] [Related]

  • 5. Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues.
    O'Neill PM, Willock DJ, Hawley SR, Bray PG, Storr RC, Ward SA, Park BK.
    J Med Chem; 1997 Feb 14; 40(4):437-48. PubMed ID: 9046333
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and antimalarial activity of new isotebuquine analogues.
    Miroshnikova OV, Hudson TH, Gerena L, Kyle DE, Lin AJ.
    J Med Chem; 2007 Feb 22; 50(4):889-96. PubMed ID: 17266295
    [Abstract] [Full Text] [Related]

  • 7. Novel amodiaquine congeners as potent antimalarial agents.
    Casagrande M, Basilico N, Parapini S, Romeo S, Taramelli D, Sparatore A.
    Bioorg Med Chem; 2008 Jul 15; 16(14):6813-23. PubMed ID: 18562202
    [Abstract] [Full Text] [Related]

  • 8. Synthesis and evaluation of phenylequine for antimalarial activity in vitro and in vivo.
    Blackie MA, Yardley V, Chibale K.
    Bioorg Med Chem Lett; 2010 Feb 01; 20(3):1078-80. PubMed ID: 20034790
    [Abstract] [Full Text] [Related]

  • 9. Antimalarial activity of isoquine against Kenyan Plasmodium falciparum clinical isolates and association with polymorphisms in pfcrt and pfmdr1 genes.
    Okombo J, Kiara SM, Abdirahman A, Mwai L, Ohuma E, Borrmann S, Nzila A, Ward S.
    J Antimicrob Chemother; 2013 Apr 01; 68(4):786-8. PubMed ID: 23169890
    [Abstract] [Full Text] [Related]

  • 10. Disposition of amodiaquine and related antimalarial agents in human neutrophils: implications for drug design.
    Naisbitt DJ, Ruscoe JE, Williams D, O'Neill PM, Pirmohamed M, Park BK.
    J Pharmacol Exp Ther; 1997 Feb 01; 280(2):884-93. PubMed ID: 9023303
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives.
    Solomon VR, Haq W, Srivastava K, Puri SK, Katti SB.
    J Med Chem; 2007 Jan 25; 50(2):394-8. PubMed ID: 17228883
    [Abstract] [Full Text] [Related]

  • 12. 4-Aminoquinoline resistance of Plasmodium falciparum: insights from the study of amodiaquine uptake.
    Bray PG, Hawley SR, Ward SA.
    Mol Pharmacol; 1996 Dec 25; 50(6):1551-8. PubMed ID: 8967977
    [Abstract] [Full Text] [Related]

  • 13. The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine.
    O'Neill PM, Harrison AC, Storr RC, Hawley SR, Ward SA, Park BK.
    J Med Chem; 1994 Apr 29; 37(9):1362-70. PubMed ID: 8176713
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  • 16. Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: synthesis and pharmacological evaluation.
    Ongarora DS, Gut J, Rosenthal PJ, Masimirembwa CM, Chibale K.
    Bioorg Med Chem Lett; 2012 Aug 01; 22(15):5046-50. PubMed ID: 22749280
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  • 18. Synthesis of chiral chloroquine and its analogues as antimalarial agents.
    Sinha M, Dola VR, Soni A, Agarwal P, Srivastava K, Haq W, Puri SK, Katti SB.
    Bioorg Med Chem; 2014 Nov 01; 22(21):5950-60. PubMed ID: 25284252
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