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Journal Abstract Search


1101 related items for PubMed ID: 14585973

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  • 3. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.
    Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, Talalay P.
    Proc Natl Acad Sci U S A; 2004 Feb 17; 101(7):2040-5. PubMed ID: 14764894
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  • 4. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression.
    McMahon M, Itoh K, Yamamoto M, Hayes JD.
    J Biol Chem; 2003 Jun 13; 278(24):21592-600. PubMed ID: 12682069
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  • 5. Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes.
    Kang MI, Kobayashi A, Wakabayashi N, Kim SG, Yamamoto M.
    Proc Natl Acad Sci U S A; 2004 Feb 17; 101(7):2046-51. PubMed ID: 14764898
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  • 6. Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome.
    Katoh Y, Iida K, Kang MI, Kobayashi A, Mizukami M, Tong KI, McMahon M, Hayes JD, Itoh K, Yamamoto M.
    Arch Biochem Biophys; 2005 Jan 15; 433(2):342-50. PubMed ID: 15581590
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  • 7. Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.
    Zhang DD, Lo SC, Sun Z, Habib GM, Lieberman MW, Hannink M.
    J Biol Chem; 2005 Aug 26; 280(34):30091-9. PubMed ID: 15983046
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  • 11. The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm.
    Zipper LM, Mulcahy RT.
    J Biol Chem; 2002 Sep 27; 277(39):36544-52. PubMed ID: 12145307
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  • 12. Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2.
    Eggler AL, Liu G, Pezzuto JM, van Breemen RB, Mesecar AD.
    Proc Natl Acad Sci U S A; 2005 Jul 19; 102(29):10070-5. PubMed ID: 16006525
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  • 13. Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron.
    McMahon M, Thomas N, Itoh K, Yamamoto M, Hayes JD.
    J Biol Chem; 2004 Jul 23; 279(30):31556-67. PubMed ID: 15143058
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  • 14. Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes.
    Kobayashi A, Ohta T, Yamamoto M.
    Methods Enzymol; 2004 Jul 23; 378():273-86. PubMed ID: 15038975
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  • 15. NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation.
    He X, Ma Q.
    Mol Pharmacol; 2009 Dec 23; 76(6):1265-78. PubMed ID: 19786557
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  • 16. CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1.
    Lo SC, Hannink M.
    Mol Cell Biol; 2006 Feb 23; 26(4):1235-44. PubMed ID: 16449638
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  • 17. Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism.
    Velichkova M, Hasson T.
    Mol Cell Biol; 2005 Jun 23; 25(11):4501-13. PubMed ID: 15899855
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  • 18. Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications.
    Keum YS.
    Ann N Y Acad Sci; 2011 Jul 23; 1229():184-9. PubMed ID: 21793854
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  • 19. Heteroaromatic 4-arylquinols are novel inducers of nuclear factor-erythroid 2-related factor 2 (Nrf2).
    Wong DP, Wells G, Hagen T.
    Eur J Pharmacol; 2010 Sep 25; 643(2-3):188-94. PubMed ID: 20599909
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  • 20. Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.
    Jeong WS, Keum YS, Chen C, Jain MR, Shen G, Kim JH, Li W, Kong AN.
    J Biochem Mol Biol; 2005 Mar 31; 38(2):167-76. PubMed ID: 15826493
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