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581 related items for PubMed ID: 14592453

  • 1. Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes.
    Chavez JA, Summers SA.
    Arch Biochem Biophys; 2003 Nov 15; 419(2):101-9. PubMed ID: 14592453
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  • 2. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate.
    Schmitz-Peiffer C, Craig DL, Biden TJ.
    J Biol Chem; 1999 Aug 20; 274(34):24202-10. PubMed ID: 10446195
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  • 3. A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids.
    Chavez JA, Knotts TA, Wang LP, Li G, Dobrowsky RT, Florant GL, Summers SA.
    J Biol Chem; 2003 Mar 21; 278(12):10297-303. PubMed ID: 12525490
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  • 6. Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites.
    Lee JS, Pinnamaneni SK, Eo SJ, Cho IH, Pyo JH, Kim CK, Sinclair AJ, Febbraio MA, Watt MJ.
    J Appl Physiol (1985); 2006 May 21; 100(5):1467-74. PubMed ID: 16357064
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  • 7. Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid.
    Sabin MA, Stewart CE, Crowne EC, Turner SJ, Hunt LP, Welsh GI, Grohmann MJ, Holly JM, Shield JP.
    J Cell Physiol; 2007 Apr 21; 211(1):244-52. PubMed ID: 17219404
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  • 8. Downregulation of lipin-1 induces insulin resistance by increasing intracellular ceramide accumulation in C2C12 myotubes.
    Huang S, Huang S, Wang X, Zhang Q, Liu J, Leng Y.
    Int J Biol Sci; 2017 Apr 21; 13(1):1-12. PubMed ID: 28123341
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  • 9. Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells.
    Powell DJ, Turban S, Gray A, Hajduch E, Hundal HS.
    Biochem J; 2004 Sep 01; 382(Pt 2):619-29. PubMed ID: 15193147
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  • 10. Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling.
    Chavez JA, Holland WL, Bär J, Sandhoff K, Summers SA.
    J Biol Chem; 2005 May 20; 280(20):20148-53. PubMed ID: 15774472
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  • 11. Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells: IMPLICATION OF THE DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE.
    Hage Hassan R, Pacheco de Sousa AC, Mahfouz R, Hainault I, Blachnio-Zabielska A, Bourron O, Koskas F, Górski J, Ferré P, Foufelle F, Hajduch E.
    J Biol Chem; 2016 Feb 05; 291(6):3019-29. PubMed ID: 26698173
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  • 15. Different impacts of saturated and unsaturated free fatty acids on COX-2 expression in C(2)C(12) myotubes.
    Kadotani A, Tsuchiya Y, Hatakeyama H, Katagiri H, Kanzaki M.
    Am J Physiol Endocrinol Metab; 2009 Dec 05; 297(6):E1291-303. PubMed ID: 19755671
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  • 16. Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insight.
    Mahfouz R, Khoury R, Blachnio-Zabielska A, Turban S, Loiseau N, Lipina C, Stretton C, Bourron O, Ferré P, Foufelle F, Hundal HS, Hajduch E.
    PLoS One; 2014 Dec 05; 9(7):e101865. PubMed ID: 25058613
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  • 17. Ceramide mediates inhibition of the AKT/eNOS signaling pathway by palmitate in human vascular endothelial cells.
    Xiao-Yun X, Zhuo-Xiong C, Min-Xiang L, Xingxuan H, Schuchman EH, Feng L, Han-Song X, An-Hua L.
    Med Sci Monit; 2009 Sep 05; 15(9):BR254-61. PubMed ID: 19721393
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  • 18. Increased beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite intramyocellular lipid accumulation.
    Perdomo G, Commerford SR, Richard AM, Adams SH, Corkey BE, O'Doherty RM, Brown NF.
    J Biol Chem; 2004 Jun 25; 279(26):27177-86. PubMed ID: 15105415
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  • 19. Key role for ceramides in mediating insulin resistance in human muscle cells.
    Pickersgill L, Litherland GJ, Greenberg AS, Walker M, Yeaman SJ.
    J Biol Chem; 2007 Apr 27; 282(17):12583-9. PubMed ID: 17337731
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  • 20. Leptin, skeletal muscle lipids, and lipid-induced insulin resistance.
    Dube JJ, Bhatt BA, Dedousis N, Bonen A, O'Doherty RM.
    Am J Physiol Regul Integr Comp Physiol; 2007 Aug 27; 293(2):R642-50. PubMed ID: 17491114
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