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197 related items for PubMed ID: 14596677

  • 1. Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway.
    Hirashima Y, Tsuruzoe K, Kodama S, Igata M, Toyonaga T, Ueki K, Kahn CR, Araki E.
    J Endocrinol; 2003 Nov; 179(2):253-66. PubMed ID: 14596677
    [Abstract] [Full Text] [Related]

  • 2. Insulin-like growth factor-I-dependent signal transduction pathways leading to the induction of cell growth and differentiation of human neuroblastoma cell line SH-SY5Y: the roles of MAP kinase pathway and PI 3-kinase pathway.
    Kurihara S, Hakuno F, Takahashi S.
    Endocr J; 2000 Dec; 47(6):739-51. PubMed ID: 11228049
    [Abstract] [Full Text] [Related]

  • 3. Mono- or dual-phosphorylation of akt kinase is regulated by distinct receptors that involve the common insulin receptor substrate.
    Schnyder B, Lahm H, Pittet M, Schnyder-Candrian S.
    J Recept Signal Transduct Res; 2002 Dec; 22(1-4):213-28. PubMed ID: 12503617
    [Abstract] [Full Text] [Related]

  • 4. A phosphatidylinositol 3-Kinase/p70 ribosomal S6 protein kinase pathway is required for the regulation by insulin of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase gene expression in human muscle cells.
    Roques M, Vidal H.
    J Biol Chem; 1999 Nov 26; 274(48):34005-10. PubMed ID: 10567366
    [Abstract] [Full Text] [Related]

  • 5. Multiple signaling pathways mediate interleukin-4-induced 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene expression in human breast cancer cells.
    Gingras S, Côté S, Simard J.
    Mol Endocrinol; 2000 Feb 26; 14(2):229-40. PubMed ID: 10674396
    [Abstract] [Full Text] [Related]

  • 6. Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes.
    Matsumoto M, Ogawa W, Teshigawara K, Inoue H, Miyake K, Sakaue H, Kasuga M.
    Diabetes; 2002 Jun 26; 51(6):1672-80. PubMed ID: 12031952
    [Abstract] [Full Text] [Related]

  • 7. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
    Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB.
    Proc Natl Acad Sci U S A; 2001 Apr 10; 98(8):4640-5. PubMed ID: 11287630
    [Abstract] [Full Text] [Related]

  • 8. Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells.
    Pirola L, Bonnafous S, Johnston AM, Chaussade C, Portis F, Van Obberghen E.
    J Biol Chem; 2003 May 02; 278(18):15641-51. PubMed ID: 12594228
    [Abstract] [Full Text] [Related]

  • 9. Interferon-dependent activation of the serine kinase PI 3'-kinase requires engagement of the IRS pathway but not the Stat pathway.
    Uddin S, Majchrzak B, Wang PC, Modi S, Khan MK, Fish EN, Platanias LC.
    Biochem Biophys Res Commun; 2000 Apr 02; 270(1):158-62. PubMed ID: 10733921
    [Abstract] [Full Text] [Related]

  • 10. Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin.
    Takano A, Usui I, Haruta T, Kawahara J, Uno T, Iwata M, Kobayashi M.
    Mol Cell Biol; 2001 Aug 02; 21(15):5050-62. PubMed ID: 11438661
    [Abstract] [Full Text] [Related]

  • 11. A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.
    Haruta T, Uno T, Kawahara J, Takano A, Egawa K, Sharma PM, Olefsky JM, Kobayashi M.
    Mol Endocrinol; 2000 Jun 02; 14(6):783-94. PubMed ID: 10847581
    [Abstract] [Full Text] [Related]

  • 12. PTEN expression causes feedback upregulation of insulin receptor substrate 2.
    Simpson L, Li J, Liaw D, Hennessy I, Oliner J, Christians F, Parsons R.
    Mol Cell Biol; 2001 Jun 02; 21(12):3947-58. PubMed ID: 11359902
    [Abstract] [Full Text] [Related]

  • 13. Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation.
    Greene MW, Sakaue H, Wang L, Alessi DR, Roth RA.
    J Biol Chem; 2003 Mar 07; 278(10):8199-211. PubMed ID: 12510059
    [Abstract] [Full Text] [Related]

  • 14. Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes.
    Fasshauer M, Klein J, Kriauciunas KM, Ueki K, Benito M, Kahn CR.
    Mol Cell Biol; 2001 Jan 07; 21(1):319-29. PubMed ID: 11113206
    [Abstract] [Full Text] [Related]

  • 15. Phosphatidylinositol 3-kinase and Ras/mitogen-activated protein kinase signaling pathways are required for the regulation of 5-aminolevulinate synthase gene expression by insulin.
    Scassa ME, Guberman AS, Varone CL, Cánepa ET.
    Exp Cell Res; 2001 Dec 10; 271(2):201-13. PubMed ID: 11716532
    [Abstract] [Full Text] [Related]

  • 16. GTK tyrosine kinase-induced alteration of IRS-protein signalling in insulin producing cells.
    Annerén C, Welsh M.
    Mol Med; 2002 Nov 10; 8(11):705-13. PubMed ID: 12520087
    [Abstract] [Full Text] [Related]

  • 17. Epidermal growth factor up-regulates expression of transforming growth factor beta receptor type II in human dermal fibroblasts by phosphoinositide 3-kinase/Akt signaling pathway: Resistance to epidermal growth factor stimulation in scleroderma fibroblasts.
    Yamane K, Ihn H, Tamaki K.
    Arthritis Rheum; 2003 Jun 10; 48(6):1652-66. PubMed ID: 12794834
    [Abstract] [Full Text] [Related]

  • 18. Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
    Valverde AM, Burks DJ, Fabregat I, Fisher TL, Carretero J, White MF, Benito M.
    Diabetes; 2003 Sep 10; 52(9):2239-48. PubMed ID: 12941762
    [Abstract] [Full Text] [Related]

  • 19. Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling.
    Tsuruzoe K, Emkey R, Kriauciunas KM, Ueki K, Kahn CR.
    Mol Cell Biol; 2001 Jan 10; 21(1):26-38. PubMed ID: 11113178
    [Abstract] [Full Text] [Related]

  • 20. Protection of insulin receptor substrate-3 from staurosporine-induced apoptosis.
    Kaburagi Y, Satoh S, Yamamoto-Honda R, Ito Y, Akanuma Y, Sekihara H, Yasuda K, Sasazuki T, Kadowaki T, Yazaki Y.
    Biochem Biophys Res Commun; 2003 Jan 10; 300(2):371-7. PubMed ID: 12504093
    [Abstract] [Full Text] [Related]

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