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169 related items for PubMed ID: 14598312

  • 1. Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular Abeta production.
    Wilson CA, Doms RW, Lee VM.
    J Neurosci Res; 2003 Nov 01; 74(3):361-9. PubMed ID: 14598312
    [Abstract] [Full Text] [Related]

  • 2. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
    Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ.
    Nature; 1999 Apr 08; 398(6727):513-7. PubMed ID: 10206644
    [Abstract] [Full Text] [Related]

  • 3. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.
    J Neurosci Res; 2003 Nov 01; 74(3):386-92. PubMed ID: 14598315
    [Abstract] [Full Text] [Related]

  • 4. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V, Hamdane M, Gompel M, Bégard S, Drobecq H, Ghestem A, Grosjean ME, Kostanjevecki V, Grognet P, Vanmechelen E, Buée L, Delacourte A, Sergeant N.
    Neurobiol Dis; 2005 Nov 01; 20(2):625-37. PubMed ID: 15936948
    [Abstract] [Full Text] [Related]

  • 5. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.
    J Neurochem; 2005 Sep 01; 94(5):1189-201. PubMed ID: 15992373
    [Abstract] [Full Text] [Related]

  • 6. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.
    J Neurochem; 2006 Feb 01; 96(3):732-42. PubMed ID: 16405513
    [Abstract] [Full Text] [Related]

  • 7. A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.
    Lai MT, Crouthamel MC, DiMuzio J, Pietrak BL, Donoviel DB, Bernstein A, Gardell SJ, Li YM, Hazuda D.
    J Neurochem; 2006 Jan 01; 96(1):118-25. PubMed ID: 16300640
    [Abstract] [Full Text] [Related]

  • 8. Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.
    Li G, Percontino L, Sun Q, Qazi AS, Frederikse PH.
    Mol Vis; 2003 May 01; 9():179-83. PubMed ID: 12740567
    [Abstract] [Full Text] [Related]

  • 9. Widespread gamma-secretase activity in the cell, but do we need it at the mitochondria?
    Teng FY, Tang BL.
    Biochem Biophys Res Commun; 2005 Mar 04; 328(1):1-5. PubMed ID: 15670741
    [Abstract] [Full Text] [Related]

  • 10. Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?
    Knappenberger KS, Tian G, Ye X, Sobotka-Briner C, Ghanekar SV, Greenberg BD, Scott CW.
    Biochemistry; 2004 May 25; 43(20):6208-18. PubMed ID: 15147205
    [Abstract] [Full Text] [Related]

  • 11. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
    Zhou S, Zhou H, Walian PJ, Jap BK.
    Proc Natl Acad Sci U S A; 2005 May 24; 102(21):7499-504. PubMed ID: 15890777
    [Abstract] [Full Text] [Related]

  • 12. Presenilin function and gamma-secretase activity.
    Brunkan AL, Goate AM.
    J Neurochem; 2005 May 24; 93(4):769-92. PubMed ID: 15857382
    [Abstract] [Full Text] [Related]

  • 13. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
    Esposito L, Gan L, Yu GQ, Essrich C, Mucke L.
    J Neurochem; 2004 Dec 24; 91(6):1260-74. PubMed ID: 15584903
    [Abstract] [Full Text] [Related]

  • 14. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
    Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS.
    Nat Cell Biol; 2000 Jul 24; 2(7):428-34. PubMed ID: 10878808
    [Abstract] [Full Text] [Related]

  • 15. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
    Shiraishi H, Sai X, Wang HQ, Maeda Y, Kurono Y, Nishimura M, Yanagisawa K, Komano H.
    J Neurochem; 2004 Sep 24; 90(6):1402-13. PubMed ID: 15341524
    [Abstract] [Full Text] [Related]

  • 16. Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells.
    Qi Y, Morishima-Kawashima M, Sato T, Mitsumori R, Ihara Y.
    Biochemistry; 2003 Feb 04; 42(4):1042-52. PubMed ID: 12549925
    [Abstract] [Full Text] [Related]

  • 17. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J, Ayral E, Hernandez JF, Martinez J, Checler F.
    J Neurochem; 2009 Jul 04; 110(1):275-83. PubMed ID: 19457123
    [Abstract] [Full Text] [Related]

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  • 19. Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.
    Funamoto S, Morishima-Kawashima M, Tanimura Y, Hirotani N, Saido TC, Ihara Y.
    Biochemistry; 2004 Oct 26; 43(42):13532-40. PubMed ID: 15491160
    [Abstract] [Full Text] [Related]

  • 20. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein.
    Irizarry MC, Deng A, Lleo A, Berezovska O, Von Arnim CA, Martin-Rehrmann M, Manelli A, LaDu MJ, Hyman BT, Rebeck GW.
    J Neurochem; 2004 Sep 26; 90(5):1132-43. PubMed ID: 15312168
    [Abstract] [Full Text] [Related]

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