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116 related items for PubMed ID: 14633716

  • 1. Free and N-(2-hydroxypropyl)methacrylamide copolymer-bound geldanamycin derivative induce different stress responses in A2780 human ovarian carcinoma cells.
    Nishiyama N, Nori A, Malugin A, Kasuya Y, Kopecková P, Kopecek J.
    Cancer Res; 2003 Nov 15; 63(22):7876-82. PubMed ID: 14633716
    [Abstract] [Full Text] [Related]

  • 2. Geldanamycin induces heat shock protein expression through activation of HSF1 in K562 erythroleukemic cells.
    Kim HR, Kang HS, Kim HD.
    IUBMB Life; 1999 Oct 15; 48(4):429-33. PubMed ID: 10632574
    [Abstract] [Full Text] [Related]

  • 3. Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models.
    Banerji U, Walton M, Raynaud F, Grimshaw R, Kelland L, Valenti M, Judson I, Workman P.
    Clin Cancer Res; 2005 Oct 01; 11(19 Pt 1):7023-32. PubMed ID: 16203796
    [Abstract] [Full Text] [Related]

  • 4. Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro.
    McLean PJ, Klucken J, Shin Y, Hyman BT.
    Biochem Biophys Res Commun; 2004 Aug 27; 321(3):665-9. PubMed ID: 15358157
    [Abstract] [Full Text] [Related]

  • 5. Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone.
    Clarke PA, Hostein I, Banerji U, Stefano FD, Maloney A, Walton M, Judson I, Workman P.
    Oncogene; 2000 Aug 24; 19(36):4125-33. PubMed ID: 10962573
    [Abstract] [Full Text] [Related]

  • 6. Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.
    Bisht KS, Bradbury CM, Mattson D, Kaushal A, Sowers A, Markovina S, Ortiz KL, Sieck LK, Isaacs JS, Brechbiel MW, Mitchell JB, Neckers LM, Gius D.
    Cancer Res; 2003 Dec 15; 63(24):8984-95. PubMed ID: 14695217
    [Abstract] [Full Text] [Related]

  • 7. Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models.
    Smith V, Sausville EA, Camalier RF, Fiebig HH, Burger AM.
    Cancer Chemother Pharmacol; 2005 Aug 15; 56(2):126-37. PubMed ID: 15841378
    [Abstract] [Full Text] [Related]

  • 8. Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor- and cycle-arrest-mediated cytoprotection.
    Demidenko ZN, Vivo C, Halicka HD, Li CJ, Bhalla K, Broude EV, Blagosklonny MV.
    Cell Death Differ; 2006 Sep 15; 13(9):1434-41. PubMed ID: 16311509
    [Abstract] [Full Text] [Related]

  • 9. The Ah receptor is a sensitive target of geldanamycin-induced protein turnover.
    Chen HS, Singh SS, Perdew GH.
    Arch Biochem Biophys; 1997 Dec 01; 348(1):190-8. PubMed ID: 9390191
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates.
    Kasuya Y, Lu ZR, Kopecková P, Minko T, Tabibi SE, Kopecek J.
    J Control Release; 2001 Jul 06; 74(1-3):203-11. PubMed ID: 11489496
    [Abstract] [Full Text] [Related]

  • 11. Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo.
    Schwock J, Pham NA, Cao MP, Hedley DW.
    Cancer Chemother Pharmacol; 2008 Apr 06; 61(4):669-81. PubMed ID: 17579866
    [Abstract] [Full Text] [Related]

  • 12. Transactivation of hsp70-1/2 in geldanamycin-treated human non-small cell lung cancer H460 cells: involvement of intracellular calcium and protein kinase C.
    Shu CW, Cheng NL, Chang WM, Tseng TL, Lai YK.
    J Cell Biochem; 2005 Apr 15; 94(6):1199-209. PubMed ID: 15696546
    [Abstract] [Full Text] [Related]

  • 13. Analysis of hypoxia-inducible factor-1alpha accumulation and cell cycle in geldanamycin-treated human cervical carcinoma cells by laser scanning cytometry.
    Schwock J, Geddie WR, Hedley DW.
    Cytometry A; 2005 Dec 15; 68(2):59-70. PubMed ID: 16228978
    [Abstract] [Full Text] [Related]

  • 14. Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts.
    Eiseman JL, Lan J, Lagattuta TF, Hamburger DR, Joseph E, Covey JM, Egorin MJ.
    Cancer Chemother Pharmacol; 2005 Jan 15; 55(1):21-32. PubMed ID: 15338192
    [Abstract] [Full Text] [Related]

  • 15. Geldanamycin, a HSP90 inhibitor, attenuates the hypoxia-induced vascular endothelial growth factor expression in retinal pigment epithelium cells in vitro.
    Wu WC, Kao YH, Hu PS, Chen JH.
    Exp Eye Res; 2007 Nov 15; 85(5):721-31. PubMed ID: 17870069
    [Abstract] [Full Text] [Related]

  • 16. The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation.
    Jeon YK, Park CH, Kim KY, Li YC, Kim J, Kim YA, Paik JH, Park BK, Kim CW, Kim YN.
    J Pathol; 2007 Oct 15; 213(2):170-9. PubMed ID: 17768706
    [Abstract] [Full Text] [Related]

  • 17. Geldanamycin activates Hsp70 response and attenuates okadaic acid-induced cytotoxicity in human retinal pigment epithelial cells.
    Kaarniranta K, Ryhänen T, Sironen RK, Suuronen T, Elo MA, Karjalainen HM, Lammi MJ, Teräsvirta M, Uusitalo H, Salminen A.
    Brain Res Mol Brain Res; 2005 Jun 13; 137(1-2):126-31. PubMed ID: 15950770
    [Abstract] [Full Text] [Related]

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  • 20. Up-regulation of heat shock protein 27 induces resistance to 17-allylamino-demethoxygeldanamycin through a glutathione-mediated mechanism.
    McCollum AK, Teneyck CJ, Sauer BM, Toft DO, Erlichman C.
    Cancer Res; 2006 Nov 15; 66(22):10967-75. PubMed ID: 17108135
    [Abstract] [Full Text] [Related]

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