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370 related items for PubMed ID: 14633739

  • 1. Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK.
    Wang H, Tan W, Hao B, Miao X, Zhou G, He F, Lin D.
    Cancer Res; 2003 Nov 15; 63(22):8057-61. PubMed ID: 14633739
    [Abstract] [Full Text] [Related]

  • 2. Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
    Su T, Bao Z, Zhang QY, Smith TJ, Hong JY, Ding X.
    Cancer Res; 2000 Sep 15; 60(18):5074-9. PubMed ID: 11016631
    [Abstract] [Full Text] [Related]

  • 3. CYP2A13: variable expression and role in human lung microsomal metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
    Zhang X, D'Agostino J, Wu H, Zhang QY, von Weymarn L, Murphy SE, Ding X.
    J Pharmacol Exp Ther; 2007 Nov 15; 323(2):570-8. PubMed ID: 17671098
    [Abstract] [Full Text] [Related]

  • 4. Analysis of CYP2A contributions to metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human peripheral lung microsomes.
    Brown PJ, Bedard LL, Reid KR, Petsikas D, Massey TE.
    Drug Metab Dispos; 2007 Nov 15; 35(11):2086-94. PubMed ID: 17717079
    [Abstract] [Full Text] [Related]

  • 5. Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers.
    Fujieda M, Yamazaki H, Saito T, Kiyotani K, Gyamfi MA, Sakurai M, Dosaka-Akita H, Sawamura Y, Yokota J, Kunitoh H, Kamataki T.
    Carcinogenesis; 2004 Dec 15; 25(12):2451-8. PubMed ID: 15308589
    [Abstract] [Full Text] [Related]

  • 6. Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.
    Chiang HC, Wang CY, Lee HL, Tsou TC.
    Toxicol Appl Pharmacol; 2011 Jun 01; 253(2):145-52. PubMed ID: 21473878
    [Abstract] [Full Text] [Related]

  • 7. Identification of critical amino acid residues of human CYP2A13 for the metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen.
    He XY, Shen J, Ding X, Lu AY, Hong JY.
    Drug Metab Dispos; 2004 Dec 01; 32(12):1516-21. PubMed ID: 15333516
    [Abstract] [Full Text] [Related]

  • 8. Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.
    Megaraj V, Zhou X, Xie F, Liu Z, Yang W, Ding X.
    Carcinogenesis; 2014 Jan 01; 35(1):131-7. PubMed ID: 23917075
    [Abstract] [Full Text] [Related]

  • 9. Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers.
    D'Agostino J, Zhang X, Wu H, Ling G, Wang S, Zhang QY, Liu F, Ding X.
    Drug Metab Dispos; 2008 Nov 01; 36(11):2316-23. PubMed ID: 18669584
    [Abstract] [Full Text] [Related]

  • 10. Genetic polymorphism of CYP2A6 gene and tobacco-induced lung cancer risk in male smokers.
    Ariyoshi N, Miyamoto M, Umetsu Y, Kunitoh H, Dosaka-Akita H, Sawamura Y, Yokota J, Nemoto N, Sato K, Kamataki T.
    Cancer Epidemiol Biomarkers Prev; 2002 Sep 01; 11(9):890-4. PubMed ID: 12223434
    [Abstract] [Full Text] [Related]

  • 11. Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population.
    Tan W, Chen GF, Xing DY, Song CY, Kadlubar FF, Lin DX.
    Int J Cancer; 2001 Mar 20; 95(2):96-101. PubMed ID: 11241319
    [Abstract] [Full Text] [Related]

  • 12. Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk.
    Kamataki T, Fujieda M, Kiyotani K, Iwano S, Kunitoh H.
    Biochem Biophys Res Commun; 2005 Dec 09; 338(1):306-10. PubMed ID: 16176798
    [Abstract] [Full Text] [Related]

  • 13. The missense genetic polymorphisms of human CYP2A13: functional significance in carcinogen activation and identification of a null allelic variant.
    Wang SL, He XY, Shen J, Wang JS, Hong JY.
    Toxicol Sci; 2006 Nov 09; 94(1):38-45. PubMed ID: 16917071
    [Abstract] [Full Text] [Related]

  • 14. Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13.
    Jalas JR, Ding X, Murphy SE.
    Drug Metab Dispos; 2003 Oct 09; 31(10):1199-202. PubMed ID: 12975327
    [Abstract] [Full Text] [Related]

  • 15. Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP.
    Kamataki T, Fujita K, Nakayama K, Yamazaki Y, Miyamoto M, Ariyoshi N.
    Drug Metab Rev; 2002 Aug 09; 34(3):667-76. PubMed ID: 12214673
    [Abstract] [Full Text] [Related]

  • 16. Association between CYP2A6 genetic polymorphisms and lung cancer: a meta-analysis of case-control studies.
    Liu T, Xie CB, Ma WJ, Chen WQ.
    Environ Mol Mutagen; 2013 Mar 09; 54(2):133-40. PubMed ID: 23203414
    [Abstract] [Full Text] [Related]

  • 17. CYP 1A1 polymorphism and risk of lung cancer in relation to tobacco smoking: a case-control study in China.
    Song N, Tan W, Xing D, Lin D.
    Carcinogenesis; 2001 Jan 09; 22(1):11-6. PubMed ID: 11159735
    [Abstract] [Full Text] [Related]

  • 18. [How I was enticed into molecular toxicology].
    Kamataki T.
    Yakugaku Zasshi; 2006 Dec 09; 126(12):1309-18. PubMed ID: 17139156
    [Abstract] [Full Text] [Related]

  • 19. GSTM1, GSTT1, and GSTP1 polymorphism and lung cancer risk in relation to tobacco smoking.
    Schneider J, Bernges U, Philipp M, Woitowitz HJ.
    Cancer Lett; 2004 May 10; 208(1):65-74. PubMed ID: 15105047
    [Abstract] [Full Text] [Related]

  • 20. A functional polymorphism in the SULT1A1 gene (G638A) is associated with risk of lung cancer in relation to tobacco smoking.
    Liang G, Miao X, Zhou Y, Tan W, Lin D.
    Carcinogenesis; 2004 May 10; 25(5):773-8. PubMed ID: 14688021
    [Abstract] [Full Text] [Related]

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