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Journal Abstract Search

504 related items for PubMed ID: 14640559

  • 1. Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.
    Orjales A, Mosquera R, Toledo A, Pumar MC, García N, Cortizo L, Labeaga L, Innerárity A.
    J Med Chem; 2003 Dec 04; 46(25):5512-32. PubMed ID: 14640559
    [Abstract] [Full Text] [Related]

  • 2. Further studies on conformationally constrained tricyclic tropane analogues and their uptake inhibition at monoamine transporter sites: synthesis of (Z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes as a novel class of serotonin transporter inhibitors.
    Zhang A, Zhou G, Hoepping A, Mukhopadhyaya J, Johnson KM, Zhang M, Kozikowski AP.
    J Med Chem; 2002 Apr 25; 45(9):1930-41. PubMed ID: 11960503
    [Abstract] [Full Text] [Related]

  • 3. Further SAR studies of piperidine-based analogues of cocaine. 2. Potent dopamine and serotonin reuptake inhibitors.
    Tamiz AP, Zhang J, Flippen-Anderson JL, Zhang M, Johnson KM, Deschaux O, Tella S, Kozikowski AP.
    J Med Chem; 2000 Mar 23; 43(6):1215-22. PubMed ID: 10737754
    [Abstract] [Full Text] [Related]

  • 4. Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine.
    Kolhatkar RB, Ghorai SK, George C, Reith ME, Dutta AK.
    J Med Chem; 2003 May 22; 46(11):2205-15. PubMed ID: 12747792
    [Abstract] [Full Text] [Related]

  • 5. S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine.
    Millan MJ, Gobert A, Lejeune F, Newman-Tancredi A, Rivet JM, Auclair A, Peglion JL.
    J Pharmacol Exp Ther; 2001 Aug 22; 298(2):565-80. PubMed ID: 11454918
    [Abstract] [Full Text] [Related]

  • 6. Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine transporters.
    Kolhatkar R, Cook CD, Ghorai SK, Deschamps J, Beardsley PM, Reith ME, Dutta AK.
    J Med Chem; 2004 Oct 07; 47(21):5101-13. PubMed ID: 15456254
    [Abstract] [Full Text] [Related]

  • 7. Benzothienyloxy phenylpropanamines, novel dual inhibitors of serotonin and norepinephrine reuptake.
    Boot JR, Brace G, Delatour CL, Dezutter N, Fairhurst J, Findlay J, Gallagher PT, Hoes I, Mahadevan S, Mitchell SN, Rathmell RE, Richards SJ, Simmonds RG, Wallace L, Whatton MA.
    Bioorg Med Chem Lett; 2004 Nov 01; 14(21):5395-9. PubMed ID: 15454233
    [Abstract] [Full Text] [Related]

  • 8. Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites.
    Zhou J, Zhang A, Kläss T, Johnson KM, Wang CZ, Ye YP, Kozikowski AP.
    J Med Chem; 2003 May 08; 46(10):1997-2007. PubMed ID: 12723962
    [Abstract] [Full Text] [Related]

  • 9. Pharmacological and behavioral analysis of the effects of some bivalent ligand-based monoamine reuptake inhibitors.
    Tamiz AP, Bandyopadhyay BC, Zhang J, Flippen-Anderson JL, Zhang M, Wang CZ, Johnson KM, Tella S, Kozikowski AP.
    J Med Chem; 2001 May 10; 44(10):1615-22. PubMed ID: 11334571
    [Abstract] [Full Text] [Related]

  • 10. New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.
    Martínez-Esparza J, Oficialdegui AM, Pérez-Silanes S, Heras B, Orús L, Palop JA, Lasheras B, Roca J, Mourelle M, Bosch A, Del Castillo JC, Tordera R, Del Río J, Monge A.
    J Med Chem; 2001 Feb 01; 44(3):418-28. PubMed ID: 11462981
    [Abstract] [Full Text] [Related]

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  • 12. Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters.
    Béïque JC, Lavoie N, de Montigny C, Debonnel G.
    Eur J Pharmacol; 1998 May 15; 349(1):129-32. PubMed ID: 9669506
    [Abstract] [Full Text] [Related]

  • 13. Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner.
    Zhang S, Zhen J, Reith ME, Dutta AK.
    J Med Chem; 2005 Jul 28; 48(15):4962-71. PubMed ID: 16033275
    [Abstract] [Full Text] [Related]

  • 14. Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity.
    Greiner E, Boos TL, Prisinzano TE, De Martino MG, Zeglis B, Dersch CM, Marcus J, Partilla JS, Rothman RB, Jacobson AE, Rice KC.
    J Med Chem; 2006 Mar 09; 49(5):1766-72. PubMed ID: 16509591
    [Abstract] [Full Text] [Related]

  • 15. Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters.
    Dutta AK, Fei XS, Beardsley PM, Newman JL, Reith ME.
    J Med Chem; 2001 Mar 15; 44(6):937-48. PubMed ID: 11300876
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT(1A) receptors.
    Orús L, Pérez-Silanes S, Oficialdegui AM, Martínez-Esparza J, Del Castillo JC, Mourelle M, Langer T, Guccione S, Donzella G, Krovat EM, Poptodorov K, Lasheras B, Ballaz S, Hervías I, Tordera R, Del Río J, Monge A.
    J Med Chem; 2002 Sep 12; 45(19):4128-39. PubMed ID: 12213056
    [Abstract] [Full Text] [Related]

  • 17. Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules.
    Dutta AK, Davis MC, Fei XS, Beardsley PM, Cook CD, Reith ME.
    J Med Chem; 2002 Jan 31; 45(3):654-62. PubMed ID: 11806716
    [Abstract] [Full Text] [Related]

  • 18. Thiophene derivatives: a new series of potent norepinephrine and serotonin reuptake inhibitors.
    Zhang A, Zhou G, Rong SB, Johnson KM, Zhang M, Kozikowski AP.
    Bioorg Med Chem Lett; 2002 Apr 08; 12(7):993-5. PubMed ID: 11909701
    [Abstract] [Full Text] [Related]

  • 19. Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.
    Mewshaw RE, Zhou D, Zhou P, Shi X, Hornby G, Spangler T, Scerni R, Smith D, Schechter LE, Andree TH.
    J Med Chem; 2004 Jul 15; 47(15):3823-42. PubMed ID: 15239661
    [Abstract] [Full Text] [Related]

  • 20. Further structure-activity relationship studies of piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands and broad-spectrum transporter inhibitors.
    He R, Kurome T, Giberson KM, Johnson KM, Kozikowski AP.
    J Med Chem; 2005 Dec 15; 48(25):7970-9. PubMed ID: 16335921
    [Abstract] [Full Text] [Related]

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