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Journal Abstract Search

428 related items for PubMed ID: 14678999

  • 1. In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation.
    Sun X, Yang Z, Li S, Tan Y, Zhang N, Wang X, Yagi S, Yoshioka T, Takimoto A, Mitsushima K, Suginaka A, Frenkel EP, Hoffman RM.
    Cancer Res; 2003 Dec 01; 63(23):8377-83. PubMed ID: 14678999
    [Abstract] [Full Text] [Related]

  • 2. Circulating half-life of PEGylated recombinant methioninase holoenzyme is highly dose dependent on cofactor pyridoxal-5'-phosphate.
    Yang Z, Sun X, Li S, Tan Y, Wang X, Zhang N, Yagi S, Takakura T, Kobayashi Y, Takimoto A, Yoshioka T, Suginaka A, Frenkel EP, Hoffman RM.
    Cancer Res; 2004 Aug 15; 64(16):5775-8. PubMed ID: 15313919
    [Abstract] [Full Text] [Related]

  • 3. PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates.
    Yang Z, Wang J, Lu Q, Xu J, Kobayashi Y, Takakura T, Takimoto A, Yoshioka T, Lian C, Chen C, Zhang D, Zhang Y, Li S, Sun X, Tan Y, Yagi S, Frenkel EP, Hoffman RM.
    Cancer Res; 2004 Sep 15; 64(18):6673-8. PubMed ID: 15374983
    [Abstract] [Full Text] [Related]

  • 4. Polyethylene glycol conjugation of recombinant methioninase for cancer therapy.
    Tan Y, Sun X, Xu M, An Z, Tan X, Han Q, Miljkovic DA, Yang M, Hoffman RM.
    Protein Expr Purif; 1998 Feb 15; 12(1):45-52. PubMed ID: 9473456
    [Abstract] [Full Text] [Related]

  • 5. Development of Recombinant Methioninase for Cancer Treatment.
    Hoffman RM, Tan Y, Li S, Han Q, Yagi S, Takakura T, Takimoto A, Inagaki K, Kudou D.
    Methods Mol Biol; 2019 Feb 15; 1866():107-131. PubMed ID: 30725412
    [Abstract] [Full Text] [Related]

  • 6. Protein carboxyl amidation increases the potential extent of protein polyethylene glycol conjugation.
    Li S, Yang Z, Sun X, Tan Y, Yagi S, Hoffman RM.
    Anal Biochem; 2004 Jul 15; 330(2):264-71. PubMed ID: 15203332
    [Abstract] [Full Text] [Related]

  • 7. Safety and Toxicity of Recombinant Methioninase and Polyethylene Glycol (PEG) Recombinant Methioninase in Primates.
    Hoffman RM, Yang Z, Tan Y, Han Q, Li S, Yagi S.
    Methods Mol Biol; 2019 Jul 15; 1866():211-229. PubMed ID: 30725418
    [Abstract] [Full Text] [Related]

  • 8. Physicochemical and pharmacokinetic characterization of highly potent recombinant L-methionine gamma-lyase conjugated with polyethylene glycol as an antitumor agent.
    Takakura T, Takimoto A, Notsu Y, Yoshida H, Ito T, Nagatome H, Ohno M, Kobayashi Y, Yoshioka T, Inagaki K, Yagi S, Hoffman RM, Esaki N.
    Cancer Res; 2006 Mar 01; 66(5):2807-14. PubMed ID: 16510603
    [Abstract] [Full Text] [Related]

  • 9. Overexpression and large-scale production of recombinant L-methionine-alpha-deamino-gamma-mercaptomethane-lyase for novel anticancer therapy.
    Tan Y, Xu M, Tan X, Tan X, Wang X, Saikawa Y, Nagahama T, Sun X, Lenz M, Hoffman RM.
    Protein Expr Purif; 1997 Mar 01; 9(2):233-45. PubMed ID: 9056489
    [Abstract] [Full Text] [Related]

  • 10. Efficacy of recombinant methioninase in combination with cisplatin on human colon tumors in nude mice.
    Tan Y, Sun X, Xu M, Tan X, Sasson A, Rashidi B, Han Q, Tan X, Wang X, An Z, Sun FX, Hoffman RM.
    Clin Cancer Res; 1999 Aug 01; 5(8):2157-63. PubMed ID: 10473100
    [Abstract] [Full Text] [Related]

  • 11. Broad selective efficacy of recombinant methioninase and polyethylene glycol-modified recombinant methioninase on cancer cells In Vitro.
    Tan Y, Xu M, Hoffman RM.
    Anticancer Res; 2010 Apr 01; 30(4):1041-6. PubMed ID: 20530407
    [Abstract] [Full Text] [Related]

  • 12. Broad selective efficacy of rMETase and PEG-rMETase on cancer cells in vitro.
    Tan Y, Xu M, Hoffman RM.
    Anticancer Res; 2010 Mar 01; 30(3):793-8. PubMed ID: 20392998
    [Abstract] [Full Text] [Related]

  • 13. Anticancer efficacy in vivo and in vitro, synergy with 5-fluorouracil, and safety of recombinant methioninase.
    Yoshioka T, Wada T, Uchida N, Maki H, Yoshida H, Ide N, Kasai H, Hojo K, Shono K, Maekawa R, Yagi S, Hoffman RM, Sugita K.
    Cancer Res; 1998 Jun 15; 58(12):2583-7. PubMed ID: 9635582
    [Abstract] [Full Text] [Related]

  • 14. Methioninase gene therapy of human cancer cells is synergistic with recombinant methioninase treatment.
    Miki K, Al-Refaie W, Xu M, Jiang P, Tan Y, Bouvet M, Zhao M, Gupta A, Chishima T, Shimada H, Makuuchi M, Moossa AR, Hoffman RM.
    Cancer Res; 2000 May 15; 60(10):2696-702. PubMed ID: 10825143
    [Abstract] [Full Text] [Related]

  • 15. Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients.
    Tan Y, Zavala J, Han Q, Xu M, Sun X, Tan X, Tan X, Magana R, Geller J, Hoffman RM.
    Anticancer Res; 1997 May 15; 17(5B):3857-60. PubMed ID: 9427792
    [Abstract] [Full Text] [Related]

  • 16. Survival efficacy of the combination of the methioninase gene and methioninase in a lung cancer orthotopic model.
    Miki K, Xu M, An Z, Wang X, Yang M, Al-Refaie W, Sun X, Baranov E, Tan Y, Chishima T, Shimada H, Moossa AR, Hoffman RM.
    Cancer Gene Ther; 2000 Feb 15; 7(2):332-8. PubMed ID: 10770644
    [Abstract] [Full Text] [Related]

  • 17. Depletion of serum methionine by methioninase in mice.
    Lishko VK, Lishko OV, Hoffman RM.
    Anticancer Res; 1993 Feb 15; 13(5A):1465-8. PubMed ID: 8239522
    [Abstract] [Full Text] [Related]

  • 18. Enhanced circulating half-life and antitumor activity of a site-specific pegylated interferon-alpha protein therapeutic.
    Bell SJ, Fam CM, Chlipala EA, Carlson SJ, Lee JI, Rosendahl MS, Doherty DH, Cox GN.
    Bioconjug Chem; 2008 Jan 15; 19(1):299-305. PubMed ID: 18020402
    [Abstract] [Full Text] [Related]

  • 19. PEGylated murine Granulocyte-macrophage colony-stimulating factor: production, purification, and characterization.
    Sainathan SK, Tu L, Bishnupuri KS, Han M, Li A, Newberry RD, McDonald KG, Crimmins DL, Houchen C, Anant S, Dieckgraefe BK.
    Protein Expr Purif; 2005 Dec 15; 44(2):94-103. PubMed ID: 16213750
    [Abstract] [Full Text] [Related]

  • 20. Treatment of cancer cells with methioninase produces DNA hypomethylation and increases DNA synthesis.
    Machover D, Zittoun J, Saffroy R, Broët P, Giraudier S, Magnaldo T, Goldschmidt E, Debuire B, Orrico M, Tan Y, Mishal Z, Chevallier O, Tonetti C, Jouault H, Ulusakarya A, Tanguy ML, Metzger G, Hoffman RM.
    Cancer Res; 2002 Aug 15; 62(16):4685-9. PubMed ID: 12183426
    [Abstract] [Full Text] [Related]

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