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213 related items for PubMed ID: 14681216

  • 1. WNK1 activates ERK5 by an MEKK2/3-dependent mechanism.
    Xu BE, Stippec S, Lenertz L, Lee BH, Zhang W, Lee YK, Cobb MH.
    J Biol Chem; 2004 Feb 27; 279(9):7826-31. PubMed ID: 14681216
    [Abstract] [Full Text] [Related]

  • 2. MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway.
    Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL.
    J Biol Chem; 2001 Feb 16; 276(7):5093-100. PubMed ID: 11073940
    [Abstract] [Full Text] [Related]

  • 3. PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway.
    Nakamura K, Johnson GL.
    J Biol Chem; 2003 Sep 26; 278(39):36989-92. PubMed ID: 12912994
    [Abstract] [Full Text] [Related]

  • 4. MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src.
    Sun W, Wei X, Kesavan K, Garrington TP, Fan R, Mei J, Anderson SM, Gelfand EW, Johnson GL.
    Mol Cell Biol; 2003 Apr 26; 23(7):2298-308. PubMed ID: 12640115
    [Abstract] [Full Text] [Related]

  • 5. Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1.
    Takeda AN, Oberoi-Khanuja TK, Glatz G, Schulenburg K, Scholz RP, Carpy A, Macek B, Remenyi A, Rajalingam K.
    EMBO J; 2014 Aug 18; 33(16):1784-801. PubMed ID: 24975362
    [Abstract] [Full Text] [Related]

  • 6. Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells.
    Chayama K, Papst PJ, Garrington TP, Pratt JC, Ishizuka T, Webb S, Ganiatsas S, Zon LI, Sun W, Johnson GL, Gelfand EW.
    Proc Natl Acad Sci U S A; 2001 Apr 10; 98(8):4599-604. PubMed ID: 11274363
    [Abstract] [Full Text] [Related]

  • 7. MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells.
    Wei X, Sun W, Fan R, Hahn J, Joetham A, Li G, Webb S, Garrington T, Dakhama A, Lucas J, Johnson GL, Gelfand EW.
    Eur J Immunol; 2003 Oct 10; 33(10):2903-9. PubMed ID: 14515274
    [Abstract] [Full Text] [Related]

  • 8. Mutations in protein kinase subdomain X differentially affect MEKK2 and MEKK1 activity.
    Huang J, Tu Z, Lee FS.
    Biochem Biophys Res Commun; 2003 Apr 04; 303(2):532-40. PubMed ID: 12659851
    [Abstract] [Full Text] [Related]

  • 9. MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway.
    Chao TH, Hayashi M, Tapping RI, Kato Y, Lee JD.
    J Biol Chem; 1999 Dec 17; 274(51):36035-8. PubMed ID: 10593883
    [Abstract] [Full Text] [Related]

  • 10. MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation.
    Raviv Z, Kalie E, Seger R.
    J Cell Sci; 2004 Apr 01; 117(Pt 9):1773-84. PubMed ID: 15075238
    [Abstract] [Full Text] [Related]

  • 11. MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells.
    Garrington TP, Ishizuka T, Papst PJ, Chayama K, Webb S, Yujiri T, Sun W, Sather S, Russell DM, Gibson SB, Keller G, Gelfand EW, Johnson GL.
    EMBO J; 2000 Oct 16; 19(20):5387-95. PubMed ID: 11032806
    [Abstract] [Full Text] [Related]

  • 12. MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts.
    Kesavan K, Lobel-Rice K, Sun W, Lapadat R, Webb S, Johnson GL, Garrington TP.
    J Cell Physiol; 2004 Apr 16; 199(1):140-8. PubMed ID: 14978743
    [Abstract] [Full Text] [Related]

  • 13. Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway.
    Mody N, Leitch J, Armstrong C, Dixon J, Cohen P.
    FEBS Lett; 2001 Jul 27; 502(1-2):21-4. PubMed ID: 11478941
    [Abstract] [Full Text] [Related]

  • 14. In vitro activity of MEKK2 and MEKK3 in detergents is a function of a valine to serine difference in the catalytic domain.
    Widmann C, Sather S, Oyer R, Johnson GL, Dreskin SC.
    Biochim Biophys Acta; 2001 May 05; 1547(1):167-73. PubMed ID: 11343802
    [Abstract] [Full Text] [Related]

  • 15. WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism.
    Xu BE, Stippec S, Lazrak A, Huang CL, Cobb MH.
    J Biol Chem; 2005 Oct 07; 280(40):34218-23. PubMed ID: 16081417
    [Abstract] [Full Text] [Related]

  • 16. PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation.
    Nakamura K, Uhlik MT, Johnson NL, Hahn KM, Johnson GL.
    Mol Cell Biol; 2006 Mar 07; 26(6):2065-79. PubMed ID: 16507987
    [Abstract] [Full Text] [Related]

  • 17. Noncanonical function of MEKK2 and MEK5 PB1 domains for coordinated extracellular signal-regulated kinase 5 and c-Jun N-terminal kinase signaling.
    Nakamura K, Johnson GL.
    Mol Cell Biol; 2007 Jun 07; 27(12):4566-77. PubMed ID: 17452462
    [Abstract] [Full Text] [Related]

  • 18. Brain-derived neurotrophic factor activates ERK5 in cortical neurons via a Rap1-MEKK2 signaling cascade.
    Wang Y, Su B, Xia Z.
    J Biol Chem; 2006 Nov 24; 281(47):35965-74. PubMed ID: 17003042
    [Abstract] [Full Text] [Related]

  • 19. Platelet-derived growth factor (PDGF)-induced activation of Erk5 MAP-kinase is dependent on Mekk2, Mek1/2, PKC and PI3-kinase, and affects BMP signaling.
    Tsioumpekou M, Papadopoulos N, Burovic F, Heldin CH, Lennartsson J.
    Cell Signal; 2016 Sep 24; 28(9):1422-1431. PubMed ID: 27339033
    [Abstract] [Full Text] [Related]

  • 20. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases.
    Vitari AC, Deak M, Morrice NA, Alessi DR.
    Biochem J; 2005 Oct 01; 391(Pt 1):17-24. PubMed ID: 16083423
    [Abstract] [Full Text] [Related]

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