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Journal Abstract Search

355 related items for PubMed ID: 14684311

  • 1. Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives.
    Beaulieu PL, Bös M, Bousquet Y, Fazal G, Gauthier J, Gillard J, Goulet S, LaPlante S, Poupart MA, Lefebvre S, McKercher G, Pellerin C, Austel V, Kukolj G.
    Bioorg Med Chem Lett; 2004 Jan 05; 14(1):119-24. PubMed ID: 14684311
    [Abstract] [Full Text] [Related]

  • 2. Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency.
    Beaulieu PL, Bös M, Bousquet Y, DeRoy P, Fazal G, Gauthier J, Gillard J, Goulet S, McKercher G, Poupart MA, Valois S, Kukolj G.
    Bioorg Med Chem Lett; 2004 Feb 23; 14(4):967-71. PubMed ID: 15013003
    [Abstract] [Full Text] [Related]

  • 3. Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.
    McKercher G, Beaulieu PL, Lamarre D, LaPlante S, Lefebvre S, Pellerin C, Thauvette L, Kukolj G.
    Nucleic Acids Res; 2004 Feb 23; 32(2):422-31. PubMed ID: 14739234
    [Abstract] [Full Text] [Related]

  • 4. Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase.
    Reddy TJ, Chan L, Turcotte N, Proulx M, Pereira OZ, Das SK, Siddiqui A, Wang W, Poisson C, Yannopoulos CG, Bilimoria D, L'Heureux L, Alaoui HM, Nguyen-Ba N.
    Bioorg Med Chem Lett; 2003 Oct 06; 13(19):3341-4. PubMed ID: 12951122
    [Abstract] [Full Text] [Related]

  • 5. Design and synthesis of lactam-thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors.
    Barnes-Seeman D, Boiselle C, Capacci-Daniel C, Chopra R, Hoffmaster K, Jones CT, Kato M, Lin K, Ma S, Pan G, Shu L, Wang J, Whiteman L, Xu M, Zheng R, Fu J.
    Bioorg Med Chem Lett; 2014 Aug 15; 24(16):3979-85. PubMed ID: 24986660
    [Abstract] [Full Text] [Related]

  • 6. Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.
    Mish MR, Cho A, Kirschberg T, Xu J, Zonte CS, Fenaux M, Park Y, Babusis D, Feng JY, Ray AS, Kim CU.
    Bioorg Med Chem Lett; 2014 Jul 15; 24(14):3092-5. PubMed ID: 24907145
    [Abstract] [Full Text] [Related]

  • 7. Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase.
    Kukolj G, McGibbon GA, McKercher G, Marquis M, Lefèbvre S, Thauvette L, Gauthier J, Goulet S, Poupart MA, Beaulieu PL.
    J Biol Chem; 2005 Nov 25; 280(47):39260-7. PubMed ID: 16188890
    [Abstract] [Full Text] [Related]

  • 8. 2-(3-Thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acids as inhibitors of HCV NS5B RdRp.
    Pacini B, Avolio S, Ercolani C, Koch U, Migliaccio G, Narjes F, Pacini L, Tomei L, Harper S.
    Bioorg Med Chem Lett; 2009 Nov 01; 19(21):6245-9. PubMed ID: 19800789
    [Abstract] [Full Text] [Related]

  • 9. Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole.
    Ishida T, Suzuki T, Hirashima S, Mizutani K, Yoshida A, Ando I, Ikeda S, Adachi T, Hashimoto H.
    Bioorg Med Chem Lett; 2006 Apr 01; 16(7):1859-63. PubMed ID: 16455252
    [Abstract] [Full Text] [Related]

  • 10. Parallel synthesis of 5-cyano-6-aryl-2-thiouracil derivatives as inhibitors for hepatitis C viral NS5B RNA-dependent RNA polymerase.
    Ding Y, Girardet JL, Smith KL, Larson G, Prigaro B, Wu JZ, Yao N.
    Bioorg Chem; 2006 Feb 01; 34(1):26-38. PubMed ID: 16360193
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and antiviral properties of novel tetracyclic nucleoside inhibitors of hepatitis C NS5B polymerase.
    Di Francesco ME, Avolio S, Dessole G, Koch U, Pompei M, Pucci V, Rowley M, Summa V.
    Nucleosides Nucleotides Nucleic Acids; 2012 Feb 01; 31(8):592-607. PubMed ID: 22908950
    [Abstract] [Full Text] [Related]

  • 12. Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides.
    Cheng CC, Shipps GW, Yang Z, Kawahata N, Lesburg CA, Duca JS, Bandouveres J, Bracken JD, Jiang CK, Agrawal S, Ferrari E, Huang HC.
    Bioorg Med Chem Lett; 2010 Apr 01; 20(7):2119-24. PubMed ID: 20219368
    [Abstract] [Full Text] [Related]

  • 13. [Non-hydrolysable analogs of inorganic pyrophosphate as inhibitors of hepatitis C virus RNA-dependent RNA-polymerase].
    Ianvarev DV, Korovina AN, Usanov NN, Kochetkov SN.
    Bioorg Khim; 2012 Apr 01; 38(2):257-62. PubMed ID: 22792731
    [Abstract] [Full Text] [Related]

  • 14. Non-nucleoside inhibitors of the hepatitis C virus NS5B RNA-dependant RNA polymerase: 2-aryl-3-heteroaryl-1,3-thiazolidin-4-one derivatives.
    Rawal RK, Katti SB, Kaushik-Basu N, Arora P, Pan Z.
    Bioorg Med Chem Lett; 2008 Dec 01; 18(23):6110-4. PubMed ID: 18947995
    [Abstract] [Full Text] [Related]

  • 15. Current perspective of HCV NS5B inhibitors: a review.
    Patil VM, Gupta SP, Samanta S, Masand N.
    Curr Med Chem; 2011 Dec 01; 18(36):5564-97. PubMed ID: 22172066
    [Abstract] [Full Text] [Related]

  • 16. Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase.
    Chan L, Reddy TJ, Proulx M, Das SK, Pereira O, Wang W, Siddiqui A, Yannopoulos CG, Poisson C, Turcotte N, Drouin A, Alaoui-Ismaili MH, Bethell R, Hamel M, L'Heureux L, Bilimoria D, Nguyen-Ba N.
    J Med Chem; 2003 Apr 10; 46(8):1283-5. PubMed ID: 12672227
    [Abstract] [Full Text] [Related]

  • 17. Discovery of 4H-pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase.
    Deng Y, Shipps GW, Wang T, Popovici-Muller J, Rosner KE, Siddiqui MA, Duca J, Cooper AB, Cable M.
    Bioorg Med Chem Lett; 2009 Sep 15; 19(18):5363-7. PubMed ID: 19682898
    [Abstract] [Full Text] [Related]

  • 18. Discovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B.
    Schoenfeld RC, Bourdet DL, Brameld KA, Chin E, de Vicente J, Fung A, Harris SF, Lee EK, Le Pogam S, Leveque V, Li J, Lui AS, Najera I, Rajyaguru S, Sangi M, Steiner S, Talamas FX, Taygerly JP, Zhao J.
    J Med Chem; 2013 Oct 24; 56(20):8163-82. PubMed ID: 24069953
    [Abstract] [Full Text] [Related]

  • 19. Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.
    Maynard A, Crosby RM, Ellis B, Hamatake R, Hong Z, Johns BA, Kahler KM, Koble C, Leivers A, Leivers MR, Mathis A, Peat AJ, Pouliot JJ, Roberts CD, Samano V, Schmidt RM, Smith GK, Spaltenstein A, Stewart EL, Thommes P, Turner EM, Voitenleitner C, Walker JT, Waitt G, Weatherhead J, Weaver K, Williams S, Wright L, Xiong ZZ, Haigh D, Shotwell JB.
    J Med Chem; 2014 Mar 13; 57(5):1902-13. PubMed ID: 23672667
    [Abstract] [Full Text] [Related]

  • 20. Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
    Tomei L, Altamura S, Bartholomew L, Biroccio A, Ceccacci A, Pacini L, Narjes F, Gennari N, Bisbocci M, Incitti I, Orsatti L, Harper S, Stansfield I, Rowley M, De Francesco R, Migliaccio G.
    J Virol; 2003 Dec 13; 77(24):13225-31. PubMed ID: 14645579
    [Abstract] [Full Text] [Related]

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