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Journal Abstract Search

239 related items for PubMed ID: 14699101

  • 1. Physicochemical features of the HERG channel drug binding site.
    Fernandez D, Ghanta A, Kauffman GW, Sanguinetti MC.
    J Biol Chem; 2004 Mar 12; 279(11):10120-7. PubMed ID: 14699101
    [Abstract] [Full Text] [Related]

  • 2. Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels.
    Chen J, Seebohm G, Sanguinetti MC.
    Proc Natl Acad Sci U S A; 2002 Sep 17; 99(19):12461-6. PubMed ID: 12209010
    [Abstract] [Full Text] [Related]

  • 3. Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain.
    Sănchez-Chapula JA, Ferrer T, Navarro-Polanco RA, Sanguinetti MC.
    Mol Pharmacol; 2003 May 17; 63(5):1051-8. PubMed ID: 12695533
    [Abstract] [Full Text] [Related]

  • 4. A structural basis for drug-induced long QT syndrome.
    Mitcheson JS, Chen J, Lin M, Culberson C, Sanguinetti MC.
    Proc Natl Acad Sci U S A; 2000 Oct 24; 97(22):12329-33. PubMed ID: 11005845
    [Abstract] [Full Text] [Related]

  • 5. Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs.
    Sanguinetti MC, Chen J, Fernandez D, Kamiya K, Mitcheson J, Sanchez-Chapula JA.
    Novartis Found Symp; 2005 Oct 24; 266():159-66; discussion 166-70. PubMed ID: 16050267
    [Abstract] [Full Text] [Related]

  • 6. Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block.
    Sánchez-Chapula JA, Navarro-Polanco RA, Culberson C, Chen J, Sanguinetti MC.
    J Biol Chem; 2002 Jun 28; 277(26):23587-95. PubMed ID: 11960982
    [Abstract] [Full Text] [Related]

  • 7. The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations.
    Ficker E, Obejero-Paz CA, Zhao S, Brown AM.
    J Biol Chem; 2002 Feb 15; 277(7):4989-98. PubMed ID: 11741928
    [Abstract] [Full Text] [Related]

  • 8. Molecular determinants of hERG channel block by terfenadine and cisapride.
    Kamiya K, Niwa R, Morishima M, Honjo H, Sanguinetti MC.
    J Pharmacol Sci; 2008 Nov 15; 108(3):301-7. PubMed ID: 18987434
    [Abstract] [Full Text] [Related]

  • 9. Structural determinants of HERG channel block by clofilium and ibutilide.
    Perry M, de Groot MJ, Helliwell R, Leishman D, Tristani-Firouzi M, Sanguinetti MC, Mitcheson J.
    Mol Pharmacol; 2004 Aug 15; 66(2):240-9. PubMed ID: 15266014
    [Abstract] [Full Text] [Related]

  • 10. Effects of outer mouth mutations on hERG channel function: a comparison with similar mutations in the Shaker channel.
    Fan JS, Jiang M, Dun W, McDonald TV, Tseng GN.
    Biophys J; 1999 Jun 15; 76(6):3128-40. PubMed ID: 10354437
    [Abstract] [Full Text] [Related]

  • 11. Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines.
    Taglialatela M, Pannaccione A, Castaldo P, Giorgio G, Zhou Z, January CT, Genovese A, Marone G, Annunziato L.
    Mol Pharmacol; 1998 Jul 15; 54(1):113-21. PubMed ID: 9658196
    [Abstract] [Full Text] [Related]

  • 12. The antihistamine fexofenadine does not affect I(Kr) currents in a case report of drug-induced cardiac arrhythmia.
    Scherer CR, Lerche C, Decher N, Dennis AT, Maier P, Ficker E, Busch AE, Wollnik B, Steinmeyer K.
    Br J Pharmacol; 2002 Nov 15; 137(6):892-900. PubMed ID: 12411421
    [Abstract] [Full Text] [Related]

  • 13.
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  • 14. Molecular determinants of dofetilide block of HERG K+ channels.
    Ficker E, Jarolimek W, Kiehn J, Baumann A, Brown AM.
    Circ Res; 1998 Feb 23; 82(3):386-95. PubMed ID: 9486667
    [Abstract] [Full Text] [Related]

  • 15.
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  • 16. Open channel block of HERG K(+) channels by vesnarinone.
    Kamiya K, Mitcheson JS, Yasui K, Kodama I, Sanguinetti MC.
    Mol Pharmacol; 2001 Aug 23; 60(2):244-53. PubMed ID: 11455010
    [Abstract] [Full Text] [Related]

  • 17. Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.
    Mitcheson JS, Chen J, Sanguinetti MC.
    J Gen Physiol; 2000 Mar 23; 115(3):229-40. PubMed ID: 10694252
    [Abstract] [Full Text] [Related]

  • 18. Mapping the binding site of a human ether-a-go-go-related gene-specific peptide toxin (ErgTx) to the channel's outer vestibule.
    Pardo-Lopez L, Zhang M, Liu J, Jiang M, Possani LD, Tseng GN.
    J Biol Chem; 2002 May 10; 277(19):16403-11. PubMed ID: 11864985
    [Abstract] [Full Text] [Related]

  • 19. An amino acid residue whose change by mutation affects drug binding to the HERG channel.
    Ishii K, Kondo K, Takahashi M, Kimura M, Endoh M.
    FEBS Lett; 2001 Oct 12; 506(3):191-5. PubMed ID: 11602243
    [Abstract] [Full Text] [Related]

  • 20. Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole.
    Suessbrich H, Waldegger S, Lang F, Busch AE.
    FEBS Lett; 1996 Apr 29; 385(1-2):77-80. PubMed ID: 8641472
    [Abstract] [Full Text] [Related]

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