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387 related items for PubMed ID: 14707268

  • 1. Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia cells.
    Rosato RR, Almenara JA, Dai Y, Grant S.
    Mol Cancer Ther; 2003 Dec; 2(12):1273-84. PubMed ID: 14707268
    [Abstract] [Full Text] [Related]

  • 2. Potent antileukemic interactions between flavopiridol and TRAIL/Apo2L involve flavopiridol-mediated XIAP downregulation.
    Rosato RR, Dai Y, Almenara JA, Maggio SC, Grant S.
    Leukemia; 2004 Nov; 18(11):1780-8. PubMed ID: 15385934
    [Abstract] [Full Text] [Related]

  • 3. Interactive effects of histone deacetylase inhibitors and TRAIL on apoptosis in human leukemia cells: involvement of both death receptor and mitochondrial pathways.
    Shankar S, Singh TR, Fandy TE, Luetrakul T, Ross DD, Srivastava RK.
    Int J Mol Med; 2005 Dec; 16(6):1125-38. PubMed ID: 16273296
    [Abstract] [Full Text] [Related]

  • 4. The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells.
    Maggio SC, Rosato RR, Kramer LB, Dai Y, Rahmani M, Paik DS, Czarnik AC, Payne SG, Spiegel S, Grant S.
    Cancer Res; 2004 Apr 01; 64(7):2590-600. PubMed ID: 15059916
    [Abstract] [Full Text] [Related]

  • 5. Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling complex activity and apoptosis of human acute leukemia cells.
    Guo F, Sigua C, Tao J, Bali P, George P, Li Y, Wittmann S, Moscinski L, Atadja P, Bhalla K.
    Cancer Res; 2004 Apr 01; 64(7):2580-9. PubMed ID: 15059915
    [Abstract] [Full Text] [Related]

  • 6. Potentiation of the lethality of the histone deacetylase inhibitor LAQ824 by the cyclin-dependent kinase inhibitor roscovitine in human leukemia cells.
    Rosato RR, Almenara JA, Maggio SC, Atadja P, Craig R, Vrana J, Dent P, Grant S.
    Mol Cancer Ther; 2005 Nov 01; 4(11):1772-85. PubMed ID: 16275999
    [Abstract] [Full Text] [Related]

  • 7. The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.
    Rosato RR, Almenara JA, Grant S.
    Cancer Res; 2003 Jul 01; 63(13):3637-45. PubMed ID: 12839953
    [Abstract] [Full Text] [Related]

  • 8. Flavopiridol and histone deacetylase inhibitors promote mitochondrial injury and cell death in human leukemia cells that overexpress Bcl-2.
    Dasmahapatra G, Almenara JA, Grant S.
    Mol Pharmacol; 2006 Jan 01; 69(1):288-98. PubMed ID: 16219908
    [Abstract] [Full Text] [Related]

  • 9. Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA).
    Almenara J, Rosato R, Grant S.
    Leukemia; 2002 Jul 01; 16(7):1331-43. PubMed ID: 12094258
    [Abstract] [Full Text] [Related]

  • 10. The cyclin-dependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acetate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells.
    Cartee L, Wang Z, Decker RH, Chellappan SP, Fusaro G, Hirsch KG, Sankala HM, Dent P, Grant S.
    Cancer Res; 2001 Mar 15; 61(6):2583-91. PubMed ID: 11289135
    [Abstract] [Full Text] [Related]

  • 11. Caspase-8 activation is necessary but not sufficient for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in the prostatic carcinoma cell line LNCaP.
    Rokhlin OW, Guseva NV, Tagiyev AF, Glover RA, Cohen MB.
    Prostate; 2002 Jun 01; 52(1):1-11. PubMed ID: 11992615
    [Abstract] [Full Text] [Related]

  • 12. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL.
    Dai Y, Dent P, Grant S.
    Mol Pharmacol; 2003 Dec 01; 64(6):1402-9. PubMed ID: 14645670
    [Abstract] [Full Text] [Related]

  • 13. Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways.
    Suliman A, Lam A, Datta R, Srivastava RK.
    Oncogene; 2001 Apr 19; 20(17):2122-33. PubMed ID: 11360196
    [Abstract] [Full Text] [Related]

  • 14. Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition.
    Rahmani M, Yu C, Reese E, Ahmed W, Hirsch K, Dent P, Grant S.
    Oncogene; 2003 Sep 18; 22(40):6231-42. PubMed ID: 13679862
    [Abstract] [Full Text] [Related]

  • 15. Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1).
    Chopin V, Slomianny C, Hondermarck H, Le Bourhis X.
    Exp Cell Res; 2004 Aug 15; 298(2):560-73. PubMed ID: 15265702
    [Abstract] [Full Text] [Related]

  • 16. Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma.
    Fandy TE, Shankar S, Ross DD, Sausville E, Srivastava RK.
    Neoplasia; 2005 Jul 15; 7(7):646-57. PubMed ID: 16026644
    [Abstract] [Full Text] [Related]

  • 17. TNF-related apoptosis-inducing ligand-induced apoptosis of melanoma is associated with changes in mitochondrial membrane potential and perinuclear clustering of mitochondria.
    Thomas WD, Zhang XD, Franco AV, Nguyen T, Hersey P.
    J Immunol; 2000 Nov 15; 165(10):5612-20. PubMed ID: 11067917
    [Abstract] [Full Text] [Related]

  • 18. Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines.
    Izeradjene K, Douglas L, Tillman DM, Delaney AB, Houghton JA.
    Cancer Res; 2005 Aug 15; 65(16):7436-45. PubMed ID: 16103097
    [Abstract] [Full Text] [Related]

  • 19. Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species.
    Rahmani M, Reese E, Dai Y, Bauer C, Payne SG, Dent P, Spiegel S, Grant S.
    Cancer Res; 2005 Mar 15; 65(6):2422-32. PubMed ID: 15781658
    [Abstract] [Full Text] [Related]

  • 20. The cyclin-dependent kinase inhibitor flavopiridol disrupts sodium butyrate-induced p21WAF1/CIP1 expression and maturation while reciprocally potentiating apoptosis in human leukemia cells.
    Rosato RR, Almenara JA, Cartee L, Betts V, Chellappan SP, Grant S.
    Mol Cancer Ther; 2002 Feb 15; 1(4):253-66. PubMed ID: 12467221
    [Abstract] [Full Text] [Related]

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