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445 related items for PubMed ID: 14709622

  • 1. CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor.
    Shenoy SD, Spencer TA, Mercer-Haines NA, Alipour M, Gargano MD, Runge-Morris M, Kocarek TA.
    Drug Metab Dispos; 2004 Jan; 32(1):66-71. PubMed ID: 14709622
    [Abstract] [Full Text] [Related]

  • 2. Induction of CYP3A by 2,3-oxidosqualene:lanosterol cyclase inhibitors is mediated by an endogenous squalene metabolite in primary cultured rat hepatocytes.
    Shenoy SD, Spencer TA, Mercer-Haines NA, Abdolalipour M, Wurster WL, Runge-Morris M, Kocarek TA.
    Mol Pharmacol; 2004 May; 65(5):1302-12. PubMed ID: 15102959
    [Abstract] [Full Text] [Related]

  • 3. Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists.
    Duniec-Dmuchowski Z, Ellis E, Strom SC, Kocarek TA.
    Biochem Pharmacol; 2007 Nov 15; 74(10):1535-40. PubMed ID: 17825266
    [Abstract] [Full Text] [Related]

  • 4. CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans.
    Tippin TK, Hamilton G, Moore L, Beaudet EJ, Jolley S, Brodie TA, Andrews RC, Becherer JD, McDougald DL, Gaul MD, Hoivik DJ, Mellon-Kusibab K, Lehmann J, Kliewer S, Novick S, Laethem R, Zhao Z, LeCluyse EL.
    Drug Metab Dispos; 2003 Jul 15; 31(7):870-7. PubMed ID: 12814963
    [Abstract] [Full Text] [Related]

  • 5. The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.
    Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, Tomkinson NC, LeCluyse EL, Lambert MH, Willson TM, Kliewer SA, Moore JT.
    Mol Endocrinol; 2000 Jan 15; 14(1):27-39. PubMed ID: 10628745
    [Abstract] [Full Text] [Related]

  • 6. Induction of cytochrome P450 3A by paclitaxel in mice: pivotal role of the nuclear xenobiotic receptor, pregnane X receptor.
    Nallani SC, Goodwin B, Maglich JM, Buckley DJ, Buckley AR, Desai PB.
    Drug Metab Dispos; 2003 May 15; 31(5):681-4. PubMed ID: 12695359
    [Abstract] [Full Text] [Related]

  • 7. Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation.
    Zhang H, LeCulyse E, Liu L, Hu M, Matoney L, Zhu W, Yan B.
    Arch Biochem Biophys; 1999 Aug 01; 368(1):14-22. PubMed ID: 10415106
    [Abstract] [Full Text] [Related]

  • 8. Use of dominant negative nuclear receptors to study xenobiotic-inducible gene expression in primary cultured hepatocytes.
    Kocarek TA, Shenoy SD, Mercer-Haines NA, Runge-Morris M.
    J Pharmacol Toxicol Methods; 2002 Aug 01; 47(3):177-87. PubMed ID: 12628309
    [Abstract] [Full Text] [Related]

  • 9. A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.
    Wang H, Faucette S, Sueyoshi T, Moore R, Ferguson S, Negishi M, LeCluyse EL.
    J Biol Chem; 2003 Apr 18; 278(16):14146-52. PubMed ID: 12571232
    [Abstract] [Full Text] [Related]

  • 10. Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways.
    Li L, Stanton JD, Tolson AH, Luo Y, Wang H.
    Pharm Res; 2009 Apr 18; 26(4):872-82. PubMed ID: 19034627
    [Abstract] [Full Text] [Related]

  • 11. Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes.
    Wang H, Faucette SR, Gilbert D, Jolley SL, Sueyoshi T, Negishi M, LeCluyse EL.
    Drug Metab Dispos; 2003 May 18; 31(5):620-30. PubMed ID: 12695351
    [Abstract] [Full Text] [Related]

  • 12. A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor.
    Healan-Greenberg C, Waring JF, Kempf DJ, Blomme EA, Tirona RG, Kim RB.
    Drug Metab Dispos; 2008 Mar 18; 36(3):500-7. PubMed ID: 18096673
    [Abstract] [Full Text] [Related]

  • 13. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
    Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, Ulrichova J, Anzenbacher P, Pavek P.
    Drug Metab Dispos; 2007 Jul 18; 35(7):1032-41. PubMed ID: 17392393
    [Abstract] [Full Text] [Related]

  • 14. Rat PXR reporter-gene activity correlates with the induction of CYP3A in rat precision-cut liver slices.
    Cui X, Thomas A, Montgomery D, Gu C, Morrison RA, White RE, Cheng KC.
    Comb Chem High Throughput Screen; 2005 Jun 18; 8(4):341-6. PubMed ID: 16101010
    [Abstract] [Full Text] [Related]

  • 15. Induction of CYP3A expression by dehydroepiandrosterone: involvement of the pregnane X receptor.
    Ripp SL, Fitzpatrick JL, Peters JM, Prough RA.
    Drug Metab Dispos; 2002 May 18; 30(5):570-5. PubMed ID: 11950789
    [Abstract] [Full Text] [Related]

  • 16. Lipopolysaccharide and cecal ligation/puncture differentially affect the subcellular distribution of the pregnane X receptor but consistently cause suppression of its target genes CYP3A.
    Sachdeva K, Yan B, Chichester CO.
    Shock; 2003 May 18; 19(5):469-74. PubMed ID: 12744492
    [Abstract] [Full Text] [Related]

  • 17. Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes.
    Drocourt L, Pascussi JM, Assenat E, Fabre JM, Maurel P, Vilarem MJ.
    Drug Metab Dispos; 2001 Oct 18; 29(10):1325-31. PubMed ID: 11560876
    [Abstract] [Full Text] [Related]

  • 18. Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.
    Casabar RC, Das PC, Dekrey GK, Gardiner CS, Cao Y, Rose RL, Wallace AD.
    Toxicol Appl Pharmacol; 2010 Jun 15; 245(3):335-43. PubMed ID: 20361990
    [Abstract] [Full Text] [Related]

  • 19. Kupffer cells and reactive oxygen species partially mediate lipopolysaccharide-induced downregulation of nuclear receptor pregnane x receptor and its target gene CYP3a in mouse liver.
    Xu DX, Wei W, Sun MF, Wu CY, Wang JP, Wei LZ, Zhou CF.
    Free Radic Biol Med; 2004 Jul 01; 37(1):10-22. PubMed ID: 15183191
    [Abstract] [Full Text] [Related]

  • 20. Insulin differentially affects xenobiotic-enhanced, cytochrome P-450 (CYP)2E1, CYP2B, CYP3A, and CYP4A expression in primary cultured rat hepatocytes.
    Woodcroft KJ, Novak RF.
    J Pharmacol Exp Ther; 1999 May 01; 289(2):1121-7. PubMed ID: 10215695
    [Abstract] [Full Text] [Related]

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