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154 related items for PubMed ID: 14743455

  • 1. Amino- and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through distinct toxic mechanisms: Study of 27 different presenilin 1 mutants.
    Hashimoto Y, Tsukamoto E, Niikura T, Yamagishi Y, Ishizaka M, Aiso S, Takashima A, Nishimoto I.
    J Neurosci Res; 2004 Feb 01; 75(3):417-28. PubMed ID: 14743455
    [Abstract] [Full Text] [Related]

  • 2. Death and survival of neuronal cells exposed to Alzheimer's insults.
    Niikura T, Hashimoto Y, Tajima H, Nishimoto I.
    J Neurosci Res; 2002 Nov 01; 70(3):380-91. PubMed ID: 12391601
    [Abstract] [Full Text] [Related]

  • 3. Characterization of V642I-AbetaPP-induced cytotoxicity in primary neurons.
    Niikura T, Yamada M, Chiba T, Aiso S, Matsuoka M, Nishimoto I.
    J Neurosci Res; 2004 Jul 01; 77(1):54-62. PubMed ID: 15197738
    [Abstract] [Full Text] [Related]

  • 4. Cytotoxic mechanisms by M239V presenilin 2, a little-analyzed Alzheimer's disease-causative mutant.
    Abe Y, Hashimoto Y, Tomita Y, Terashita K, Aiso S, Tajima H, Niikura T, Matsuoka M, Nishimoto I.
    J Neurosci Res; 2004 Aug 15; 77(4):583-95. PubMed ID: 15264228
    [Abstract] [Full Text] [Related]

  • 5. Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.
    Zatti G, Burgo A, Giacomello M, Barbiero L, Ghidoni R, Sinigaglia G, Florean C, Bagnoli S, Binetti G, Sorbi S, Pizzo P, Fasolato C.
    Cell Calcium; 2006 Jun 15; 39(6):539-50. PubMed ID: 16620965
    [Abstract] [Full Text] [Related]

  • 6. Presenilin-1-deficient neurons are nitric oxide-dependently killed by hydrogen peroxide in vitro.
    Nakajima M, Shirasawa T.
    Neuroscience; 2004 Jun 15; 125(3):563-8. PubMed ID: 15099670
    [Abstract] [Full Text] [Related]

  • 7. Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk, in stable transfectants expressing presenilin 1 protein.
    Hamano T, Mutoh T, Tabira T, Araki W, Kuriyama M, Mihara T, Yano S, Yamamoto H.
    Brain Res Mol Brain Res; 2005 Jun 13; 137(1-2):70-6. PubMed ID: 15950763
    [Abstract] [Full Text] [Related]

  • 8. Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insults.
    Hashimoto Y, Niikura T, Ito Y, Sudo H, Hata M, Arakawa E, Abe Y, Kita Y, Nishimoto I.
    J Neurosci; 2001 Dec 01; 21(23):9235-45. PubMed ID: 11717357
    [Abstract] [Full Text] [Related]

  • 9. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
    Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ.
    Neurobiol Dis; 1997 Dec 01; 3(4):325-37. PubMed ID: 9173929
    [Abstract] [Full Text] [Related]

  • 10. Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
    Terro F, Czech C, Esclaire F, Elyaman W, Yardin C, Baclet MC, Touchet N, Tremp G, Pradier L, Hugon J.
    J Neurosci Res; 2002 Aug 15; 69(4):530-9. PubMed ID: 12210846
    [Abstract] [Full Text] [Related]

  • 11. Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target.
    Hashimoto Y, Ito Y, Arakawa E, Kita Y, Terashita K, Niikura T, Nishimoto I.
    J Neurochem; 2002 Feb 15; 80(3):426-37. PubMed ID: 11905990
    [Abstract] [Full Text] [Related]

  • 12. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.
    Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA.
    Exp Neurol; 2004 Aug 15; 188(2):224-37. PubMed ID: 15246822
    [Abstract] [Full Text] [Related]

  • 13. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES, Martinez M, Brunkan AL, Goate A.
    J Neurochem; 2005 Jan 15; 92(2):294-301. PubMed ID: 15663477
    [Abstract] [Full Text] [Related]

  • 14. Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2.
    Hashimoto Y, Niikura T, Ito Y, Kita Y, Terashita K, Nishimoto I.
    J Pharmacol Exp Ther; 2002 Mar 15; 300(3):736-45. PubMed ID: 11861776
    [Abstract] [Full Text] [Related]

  • 15. CA1 hippocampal neuronal loss in familial Alzheimer's disease presenilin-1 E280A mutation is related to epilepsy.
    Velez-Pardo C, Arellano JI, Cardona-Gomez P, Jimenez Del Rio M, Lopera F, De Felipe J.
    Epilepsia; 2004 Jul 15; 45(7):751-6. PubMed ID: 15230697
    [Abstract] [Full Text] [Related]

  • 16. ["Death and survival of neuronal cells exposed to Alzheimer's disease-relevant insults"].
    Nishimoto I.
    Nihon Yakurigaku Zasshi; 2002 Nov 15; 120(1):11P-15P. PubMed ID: 12491768
    [Abstract] [Full Text] [Related]

  • 17. Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family.
    Grunberg J, Walter J, Loetscher H, Deuschle U, Jacobsen H, Haass C.
    Biochemistry; 1998 Feb 24; 37(8):2263-70. PubMed ID: 9485372
    [Abstract] [Full Text] [Related]

  • 18. The presenilin 1 C92S mutation increases abeta 42 production.
    Lewis PA, Perez-Tur J, Golde TE, Hardy J.
    Biochem Biophys Res Commun; 2000 Oct 14; 277(1):261-3. PubMed ID: 11027672
    [Abstract] [Full Text] [Related]

  • 19. Cell cycle-driven neuronal apoptosis specifically linked to amyloid peptide Abeta1-42 exposure is not exacerbated in a mouse model of presenilin-1 familial Alzheimer's disease.
    Malik B, Currais A, Soriano S.
    J Neurochem; 2008 Jul 14; 106(2):912-6. PubMed ID: 18466334
    [Abstract] [Full Text] [Related]

  • 20. Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice.
    Eckert A, Schindowski K, Leutner S, Luckhaus C, Touchet N, Czech C, Müller WE.
    Neurobiol Dis; 2001 Apr 14; 8(2):331-42. PubMed ID: 11300728
    [Abstract] [Full Text] [Related]

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