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294 related items for PubMed ID: 14744135

  • 1. Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta.
    Ramanadham S, Hsu FF, Zhang S, Jin C, Bohrer A, Song H, Bao S, Ma Z, Turk J.
    Biochemistry; 2004 Feb 03; 43(4):918-30. PubMed ID: 14744135
    [Abstract] [Full Text] [Related]

  • 2. Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript.
    Ramanadham S, Song H, Hsu FF, Zhang S, Crankshaw M, Grant GA, Newgard CB, Bao S, Ma Z, Turk J.
    Biochemistry; 2003 Dec 02; 42(47):13929-40. PubMed ID: 14636061
    [Abstract] [Full Text] [Related]

  • 3. Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis.
    Lei X, Zhang S, Bohrer A, Ramanadham S.
    J Biol Chem; 2008 Dec 12; 283(50):34819-32. PubMed ID: 18936091
    [Abstract] [Full Text] [Related]

  • 4. The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.
    Lei X, Zhang S, Bohrer A, Bao S, Song H, Ramanadham S.
    Biochemistry; 2007 Sep 04; 46(35):10170-85. PubMed ID: 17685585
    [Abstract] [Full Text] [Related]

  • 5. Group VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signaling.
    Song H, Wohltmann M, Tan M, Bao S, Ladenson JH, Turk J.
    J Biol Chem; 2012 Feb 17; 287(8):5528-41. PubMed ID: 22194610
    [Abstract] [Full Text] [Related]

  • 6. Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for iPLA2beta.
    Ma Z, Ramanadham S, Wohltmann M, Bohrer A, Hsu FF, Turk J.
    J Biol Chem; 2001 Apr 20; 276(16):13198-208. PubMed ID: 11278673
    [Abstract] [Full Text] [Related]

  • 7. Beta-cell calcium-independent group VIA phospholipase A(2) (iPLA(2)beta): tracking iPLA(2)beta movements in response to stimulation with insulin secretagogues in INS-1 cells.
    Bao S, Jin C, Zhang S, Turk J, Ma Z, Ramanadham S.
    Diabetes; 2004 Feb 20; 53 Suppl 1(0 1):S186-9. PubMed ID: 14749286
    [Abstract] [Full Text] [Related]

  • 8. Stimulation of insulin secretion and associated nuclear accumulation of iPLA(2)beta in INS-1 insulinoma cells.
    Ma Z, Zhang S, Turk J, Ramanadham S.
    Am J Physiol Endocrinol Metab; 2002 Apr 20; 282(4):E820-33. PubMed ID: 11882502
    [Abstract] [Full Text] [Related]

  • 9. Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2.
    Bao S, Li Y, Lei X, Wohltmann M, Jin W, Bohrer A, Semenkovich CF, Ramanadham S, Tabas I, Turk J.
    J Biol Chem; 2007 Sep 14; 282(37):27100-27114. PubMed ID: 17627946
    [Abstract] [Full Text] [Related]

  • 10. Inactivation of endoplasmic reticulum bound Ca2+-independent phospholipase A2 in renal cells during oxidative stress.
    Cummings BS, Gelasco AK, Kinsey GR, McHowat J, Schnellmann RG.
    J Am Soc Nephrol; 2004 Jun 14; 15(6):1441-51. PubMed ID: 15153555
    [Abstract] [Full Text] [Related]

  • 11. Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone.
    Franchi L, Chen G, Marina-Garcia N, Abe A, Qu Y, Bao S, Shayman JA, Turk J, Dubyak GR, Núñez G.
    J Innate Immun; 2009 Jun 14; 1(6):607-17. PubMed ID: 20160900
    [Abstract] [Full Text] [Related]

  • 12. Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s.
    Jenkins CM, Han X, Mancuso DJ, Gross RW.
    J Biol Chem; 2002 Sep 06; 277(36):32807-14. PubMed ID: 12089145
    [Abstract] [Full Text] [Related]

  • 13. Studies of the role of group VI phospholipase A2 in fatty acid incorporation, phospholipid remodeling, lysophosphatidylcholine generation, and secretagogue-induced arachidonic acid release in pancreatic islets and insulinoma cells.
    Ramanadham S, Hsu FF, Bohrer A, Ma Z, Turk J.
    J Biol Chem; 1999 May 14; 274(20):13915-27. PubMed ID: 10318801
    [Abstract] [Full Text] [Related]

  • 14. Role of an endoplasmic reticulum Ca(2+)-independent phospholipase A(2) in oxidant-induced renal cell death.
    Cummings BS, McHowat J, Schnellmann RG.
    Am J Physiol Renal Physiol; 2002 Sep 14; 283(3):F492-8. PubMed ID: 12167600
    [Abstract] [Full Text] [Related]

  • 15. Inhibition of Ca2+-independent phospholipase A2 results in insufficient insulin secretion and impaired glucose tolerance.
    Song K, Zhang X, Zhao C, Ang NT, Ma ZA.
    Mol Endocrinol; 2005 Feb 14; 19(2):504-15. PubMed ID: 15471944
    [Abstract] [Full Text] [Related]

  • 16. Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1.
    Lei X, Zhang S, Barbour SE, Bohrer A, Ford EL, Koizumi A, Papa FR, Ramanadham S.
    J Biol Chem; 2010 Feb 26; 285(9):6693-705. PubMed ID: 20032468
    [Abstract] [Full Text] [Related]

  • 17. Role of calcium-independent phospholipase A(2)β in human pancreatic islet β-cell apoptosis.
    Lei X, Zhang S, Bohrer A, Barbour SE, Ramanadham S.
    Am J Physiol Endocrinol Metab; 2012 Dec 01; 303(11):E1386-95. PubMed ID: 23074238
    [Abstract] [Full Text] [Related]

  • 18. Human calcium-independent phospholipase A2 mediates lymphocyte proliferation.
    Roshak AK, Capper EA, Stevenson C, Eichman C, Marshall LA.
    J Biol Chem; 2000 Nov 17; 275(46):35692-8. PubMed ID: 10964913
    [Abstract] [Full Text] [Related]

  • 19. A novel role of group VIB calcium-independent phospholipase A2 (iPLA2gamma) in the inducible expression of group IIA secretory PLA2 in rat fibroblastic cells.
    Kuwata H, Fujimoto C, Yoda E, Shimbara S, Nakatani Y, Hara S, Murakami M, Kudo I.
    J Biol Chem; 2007 Jul 13; 282(28):20124-32. PubMed ID: 17475622
    [Abstract] [Full Text] [Related]

  • 20. Characterization of FKGK18 as inhibitor of group VIA Ca2+-independent phospholipase A2 (iPLA2β): candidate drug for preventing beta-cell apoptosis and diabetes.
    Ali T, Kokotos G, Magrioti V, Bone RN, Mobley JA, Hancock W, Ramanadham S.
    PLoS One; 2013 Jul 13; 8(8):e71748. PubMed ID: 23977134
    [Abstract] [Full Text] [Related]

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